A Study of the effect of early supplementation of injection albumin in Outcomes of Patients with Septic Shock: a retrospective Study.

Authors

  • Sucheta Meshram
  • Tanvi Kondvilkar

Keywords:

N\A

Abstract

Background: The optimal timing of albumin administration in patients with septic shock remains unclear. While albumin is frequently used for fluid resuscitation, evidence regarding its early use and impact on clinical outcomes is inconsistent.
Objective: To evaluate the effect of early albumin administration (within 24 hours of ICU admission) on mortality and other outcomes in patients with septic shock.

Methods: This retrospective cohort study included adult patients with septic shock admitted to the ICU at a tertiary care hospital from January 2020 to December 2024. Patients were categorized into two groups: those who received albumin within 24 hours (early group) and those who received albumin later or not at all (control group). Propensity score matching was used to balance baseline characteristics. Primary outcome was 28-day mortality. Secondary outcomes included ICU length of stay, vasopressor-free days, and time to hemodynamic stabilization.

Results: A total of 80 patients were included (early albumin 40: ; control: 40). The early albumin group had a significantly lower 28-day mortality rate (25.3% vs. 36.7%, p=0.041), more vasopressor-free days (mean 15.2 vs. 11.7, p=0.003), and shorter time to hemodynamic stabilization (median 28 vs. 36 hours, p=0.027). ICU length of stay was not significantly different between the two groups.

Conclusion: Early albumin administration within 24 hours of ICU admission was associated with improved 28-day survival and faster hemodynamic stabilization in patients with septic shock. Prospective randomized trials are warranted to validate these findings.

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References

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Published

2025-08-08

How to Cite

1.
Meshram S, Kondvilkar T. A Study of the effect of early supplementation of injection albumin in Outcomes of Patients with Septic Shock: a retrospective Study. J Neonatal Surg [Internet]. 2025Aug.8 [cited 2025Sep.21];14(4S):1494-6. Available from: https://jneonatalsurg.com/index.php/jns/article/view/8805

Issue

Vol. 14 No. 4S (2025): Journal of Neonatal Surgery

Section

Original Article

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