Serum Level of Zinc in Children with Febrile Seizures
Keywords:
Febrile seizure, Serum Zinc, ChildrenAbstract
Objective: Febrile seizure is the most common pediatric population, usually occurring between six months to five years of age, which typically manifests during febrile illness. While the exact pathophysiology remains unclear, several factors are implicated, including genetic predisposition and variations in electrolyte levels such as zinc. In this study, we evaluated zinc level in children with the first FS attack and febrile children without seizure.
Materials and Methodology: This is a prospective study conducted among 30 patients with febrile seizure and 30 patient who are febrile without seizure. The children are within the age group of 6 months to 5 years. Serum zinc levels were measured by atomic absorption spectroscopy in these group.
Conclusion: Based on the present results, serum zinc level was lower in children with febrile seizures. However, further research is needed to examine the efficacy of zinc supplementation in prevention of febrile seizure
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References
Varma RR. Febrile seizures. Indian J Pediatr 2002; 69(8); 697-700.
Talebian A, Vakili Z, Talar SA, Kazemi M, Mousavi GA. Assessment of the relation between serum zinc and magnesium levels in children with febrile convulsion. Iranian j pathol 2009; 4(4):157-60.
Hosseini F, Nikkhah A, Afkhami Goli M. Serum Zinc Level in Children with Febrile Seizure. Iran J Child Neurol. 2020 winter; 14(1):43-47. PMID: 32021627; PMCID: PMC6956962.
Ehsanipour F, Talebi-Taher M, Harandi N, Kani k. Serum zinc level in children with febrile convulsion and its comparison with that of control group. Iranian J Pediatr 2009; 199:65-8.
Patel N, Ram D, Swiderska N, Mewasingh LD, RW Newton RW, Offringa M. Febrile seizures BMJ. 2015;18:351
Ebadi M, Wilt 5, Ramaley R. The role of Zinc and Zinc-binding proteins in regulation of glutamic acid decarboxylase in brain. Chemical and biological aspects of vitamin B6, Catalysis. New York: Alan R Liss; 1984; 255-275.
Cossart R, Bernard C, Ben-Ari Y. Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies. Trends Neurosci 2005; 28(2):108 15.
Macdonald RL, Kang JQ. Molecular pathology of genetic epilepsies associated with GABAA receptor subunit mutations. Epilepsy Curr 2009; 9(1):18-23.
Amiri M, Farzin L, Moassesi ME, Sajadi F. Serum trace element levels in febrile convulsion Biol Trace Elem Res. 2010;135:38–44
Margaretha L, Masloman N. Correlation between serum Zinc level and simple febrile seizure in children Pediatr Indon. 2013;50:326–330
Jun-Hwa Lee, Jeong Hyun Kim. Comparison of Serum Zinc Levels Measured by Inductively Coupled Plasma Mass Spectrometry in Preschool Children with Febrile and Afebrile Seizures. Ann Lab Med 2012; 32(3):190-3.
Ehsanipour F, Talebi-Taher M, Harandi N, Kani k. Serum zinc level in children with febrile convulsion and its comparison with that of control group. Iranian J Pediatr 2009; 199:65-8.
Ganesh R, Janakiraman L, Meenakshi B. Serum zinc levels are low in children with simple febrile seizures compared with those in children with epileptic seizures and controls. Ann Trop Paediatr 2011;31(4):345-9
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