Evaluation of Serum Potassium and Blood Sugar Changes Following Nebulized Levosalbutamol in Pediatric Patients

Authors

  • Tanya Gupta
  • Pradeep Kumar
  • Bindu T Nair
  • Praneta swarup
  • Rajeev Kumar Thapar
  • Meenakshi Bothra

DOI:

https://doi.org/10.63682/jns.v14i6S.8719

Keywords:

Levosalbutamol, Serum Potassium, Blood Sugar, Pediatric, Nebulization

Abstract

Objective: Levosalbutamol is widely used in pediatric patients for the management of bronchospasm. However, its systemic effects on serum potassium and blood sugar levels remain a concern. This study aims to evaluate the effect of nebulized levosalbutamol on serum potassium and blood sugar level in children between 1 year and 12 years of age.

Method: A cross-sectional observational study was conducted from May 2023 to November 2024 at Sharda Hospital, including 64 patients receiving Levosalbutamol nebulisation at 0,20,40 minutes in IPD. Serum potassium and blood glucose levels were measured before and after nebulization. Data was collected using a study proforma to record pertinent information including serum potassium levels, blood sugar levels and heart rate. Other factors that were observed included age, gender and type of respiratory illnesses. The statistical significance of changes was analyzed using paired t-tests, with p values ≤ 0.05 considered statistically significant.

Results: A significant decrease in serum potassium levels was observed post-nebulization (p < 0.05), along with a concurrent increase in blood glucose levels (p < 0.05). These metabolic changes were more pronounced in younger children and those receiving multiple doses.

Conclusion: Nebulized levosalbutamol induces significant hypokalemia and hyperglycemia in pediatric patients. Clinicians should monitor these parameters, particularly in patients at risk for electrolyte imbalances or glucose metabolism disorders.

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References

Rahman A. Levosalbutamol versus Salbutamol for Treatment of Acute Exacerbation of Asthma in Bangladesh Children. Journal of Allergy & Therapy 2012a;03. https://doi.org/10.4172/2155-6121.1000123.

Santana JC, Barreto SSM, Piva JP, Garcia PCR. Controlled study on intravenous magnesium sulfate or salbutamol in early treatment of severe acute asthma attack in children. Jornal De Pediatria 2001;77:279–87. https://doi.org/10.2223/jped.235.

Pancu D, LaFlamme M, Evans E, Reed J. Levalbuterol is as effective as racemic albuterol in lowering serum potassium. J Emerg Med 2003; 25(1):13-6.

Al-Azzawi OF, Al-Obaidy MW, Shihab DM. The effect of nebulized salbutamol on serum potassium and blood sugar level of asthmatic patients. Glob J Health Sci 2018; 10(9):25-34.

Lee CKK, PharmaD, MPH. Drug Dosages. In: Kleiman K, McDaniel L, Molloy M, editors.22nd ed. Philadelphia: Elseiver:2021.p.889.

Jagalamarri VL, Balleda L, Kolla S, Reddy TCS. Utility of PRESS score in predicting the outcomes of children admitted with respiratory distress: A prospective study. Pediatr Respirol crit Care Med 2021; 5(4):57-61.

Phumeetham S, Bahk TJ, Abd-Allah S, Mathur M. Effect of High-Dose Continuous Albuterol Nebulization on Clinical Variables in Children With Status Asthmaticus*. Pediatric Critical Care Medicine 2015;16:e41–6. https://doi.org/10.1097/pcc.0000000000000314.

Ramanathan R, Mahalakshmi B. Comparison of efficacy between levosalbutamol and levosalbutamol-ipratropum nebulization in mild to moderate childhood asthma. International Journal of Contemporary Pediatrics 2019;6:1952. https://doi.org/10.18203/2349-3291.ijcp20193597.

Lahiri S. Evidence behind use of levosalbutamol over salbutamol to prevent cardiac side effects. International Journal of Contemporary Pediatrics 2017;4:674. https://doi.org/10.18203/2349-3291.ijcp20171682.

Zitek T, Cleveland N, Rahbar A, Parker J, Lim C, Elsbecker S, et al. Effect of Nebulized Albuterol on Serum Lactate and Potassium in Healthy Subjects. Academic Emergency Medicine 2016;23:718–21. https://doi.org/10.1111/acem.12937.

Bakolia SK, Verma GK, Barolia DK. The Effects of nebulised salbutamol on serum potassium and blood sugar levels in asthmatic patients. Int J Med Biomed Stud 2021; 5(9):154-6.

Sharma S, Mathew JL, Singh M. Study of efficacy and safety of levosalbutamol versus racemic salbutamol delivered by metered dose inhaler in children with moderate persistent asthma. Pediatric Review International Journal of Pediatric Research 2019a;6:292–8. https://doi.org/10.17511/ijpr.2019.i06.05.

Rabbany MA, Saha BK, Subha N, Sultana I, Islam MS, Hossain AJ, et al. Comparative Efficacy of Levosalbutamol and Racemic Salbutamol in the Treatment of Acute Exacerbation of Asthma. PubMed 2023;32:10–7.

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Published

2025-08-04

How to Cite

1.
Gupta T, Kumar P, Nair BT, swarup P, Thapar RK, Bothra M. Evaluation of Serum Potassium and Blood Sugar Changes Following Nebulized Levosalbutamol in Pediatric Patients. J Neonatal Surg [Internet]. 2025Aug.4 [cited 2025Oct.11];14(6S):883-9. Available from: https://jneonatalsurg.com/index.php/jns/article/view/8719

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