Comparative Toxicodynamic Assessments of Traditional Medicines in Chronic Disease Models
Keywords:
Toxicodynamics, Chronic Disease Models, Herbal Safety, Phytotherapy, Cytotoxicity, Gene Expression, Herbal PharmacovigilanceAbstract
The increased use of traditional medicines (TMs) for the control of chronic diseases worldwide requires a scientific assessment of their safety and efficacy. Although they are thought to be safer because they come from natural sources, little is known about their pharmacokinetic and toxicodynamic characteristics, particularly in the context of chronic diseases. A comparative toxicodynamic analysis of a few common conventional medications used to treat chronic illnesses such as diabetes, cancer, heart disease, and neurological disorders is presented in this chapter.Based on both in vitro and in vivo chronic disease models, the research compares cytotoxicity, organ toxicity, markers of oxidative stress, apoptotic pathways, and alterations in gene expression caused by some selected herbal preparations. In addition, this chapter calls for regulation oversight and standardization safety profiling of TMs. The results advocate for an integrated plan for the integration of traditional medicines into evidence-based health systems
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