Green Synthesis Of Titanium Dioxide Nanoparticles By Using Ethanolic Leaf Extract Of Jatropha Curcas L.

Authors

  • Kishor Dadaso Madane
  • Sandeep Ravindra Kane
  • Shrinivas Krishna Mohite
  • Shailaja Jaykumar Kamble
  • Akshada Vivek Deshmukh
  • Avani Krushnaji Shewale

Keywords:

Fluoroquinolones (FQs), Antibacterial agents, Anticancer activity, Urinary tract infections (UTIs), Antimicrobial agents, Antioxidant

Abstract

The current study presents a green, eco-friendly approach for the synthesis of titanium dioxide (TiO₂) nanoparticles using ethanolic leaf extract of Jatropha curcas L., a medicinal plant rich in bioactive compounds. Traditional chemical and physical synthesis methods often involve hazardous reagents and energy-intensive processes; in contrast, this biological method offers a sustainable alternative. The leaves were extracted via Soxhlet apparatus using ethanol as solvent, and the resulting extract was employed in the reduction and stabilization of TiO₂ nanoparticles. The synthesized nanoparticles were characterized using GC-MS, DLS, zeta potential, SEM, and XRD techniques. GC-MS analysis confirmed the presence of twelve major phytochemicals, such as (+)-2-Bornanone, caryophyllene, alpha-pinene, and flavonoids, which are known for their antioxidant and antimicrobial properties. DLS analysis revealed an average particle size of 125 nm with a PDI of 0.410, indicating moderate monodispersity. Zeta potential analysis showed a negative surface charge of -35.2 mV, confirming high colloidal stability. SEM images revealed rough, wrinkled surfaces suggesting high surface reactivity, while XRD analysis confirmed the crystalline anatase phase of TiO₂. Antioxidant activity assessed via DPPH assay demonstrated a significant dose-dependent response, with a maximum inhibition of 73.57% at 100 µg/mL and an IC₅₀ value of 75.08 µg/mL, comparable to ascorbic acid.

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Published

2025-07-19

How to Cite

1.
Madane KD, Kane SR, Mohite SK, Kamble SJ, Deshmukh AV, Shewale AK. Green Synthesis Of Titanium Dioxide Nanoparticles By Using Ethanolic Leaf Extract Of Jatropha Curcas L. J Neonatal Surg [Internet]. 2025 Jul. 19 [cited 2026 Feb. 19];14(19S):1066-73. Available from: https://jneonatalsurg.com/index.php/jns/article/view/8390

Issue

Vol. 14 No. 19S (2025): Journal of Neonatal Surgery

Section

Original Article

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