A Promising Approach To Deliver Lipophilic Drug Candidate: Microemulsion Based Drug Delivery

Authors

  • Mital Patel
  • Piyush Patel

Keywords:

N\A

Abstract

Microemulsions are isotropic mixtures which are thermodynamically stable containing oil, water, surfactants, and co-surfactants that form spontaneously with droplet sizes ranging from 5–100 nm. These systems have gained significant attention as efficient drug delivery carriers for lipophilic and poorly water-soluble drugs. Their ability to enhance solubility, improve bioavailability, and provide controlled and targeted delivery makes them suitable for a broader range of pharmaceutical applications. This review discusses the types, classification (Winsor I–IV), formulation theories (thermodynamic, interfacial, and solubilization), excipients used, and various preparation methods such as phase inversion and titration techniques. Applications across oral, topical, ocular, nasal, parenteral, and cosmetic routes are explored, highlighting microemulsions' versatility. Characterization methods, including droplet size analysis, viscosity, and stability testing, are also covered. Overall, microemulsion-based systems offer an effective and reliable approach for delivering lipophilic drugs and therapeutic agents.

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References

Tartaro G, Mateos H, Schirone D, Angelico R, Palazzo G. Microemulsion microstructure(s): A tutorial review. Vol. 10, Nanomaterials. MDPI AG; 2020. p. 1–40.

Sareen S, Joseph L, Mathew G. Improvement in solubility of poor water-soluble drugs by solid dispersion. Int J Pharm Investig. 2012;2(1):12.

Kale SN, Deore SL. Emulsion micro emulsion and nano emulsion: A review. Vol. 8, Systematic Reviews in Pharmacy. 2016. p. 39–47.

Tartaro G, Mateos H, Schirone D, Angelico R, Palazzo G. Microemulsion microstructure(s): A tutorial review. Vol. 10, Nanomaterials. MDPI AG; 2020. p. 1–40.

Acharya DP, Hartley PG. Progress in microemulsion characterization. Vol. 17, Current Opinion in Colloid and Interface Science. 2012. p. 274–80.

Jadhav KR, Shaikh IM, Ambade KW, Kadam VJ. Applications of Microemulsion Based Drug Delivery System. Vol. 3, Current Drug Delivery. 2006.

Prakash Agrawal O, Agrawal S. Asian Journal of Pharmaceutical Science & Technology AN OVERVIEW OF NEW DRUG DELIVERY SYSTEM: MICROEMULSION [Internet]. Vol. 1. Available from: www.ajpst.com

. Santanna VC, Curbelo FDS, Castro Dantas TN, Dantas Neto AA, Albuquerque HS, Garnica AIC. Microemulsion flooding for enhanced oil recovery. J Pet Sci Eng. 2009;66(3–4):117–20.

Journals E, Gadhave A, Gadhave AD, Waghmare JT. A SHORT REVIEW ON MICROEMULSION AND ITS APPLICATION IN EXTRACTION OF VEGETABLE OIL. Available from: http://www.ijret.org

Author C, Mehta DP, Rathod HJ, Shah DP. Microemulsions: A Potential Novel Drug Delivery System. Vol. 1, International Journal of Pharmaceutical Sciences. 2015.

Tenjarla S. Microemulsions: an overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst. 1999;16(5):461–521.

Callender SP, Mathews JA, Kobernyk K, Wettig SD. Microemulsion utility in pharmaceuticals: Implications for multi‐drug delivery. Int J Pharm. 2017;526(1–2):425–42.

Chen Y, Liu DZ, Liu P, Xu Y, Zhang H. Microemulsion-based drug delivery systems for oral delivery of peptide and protein drugs: Barriers, strategies, and future prospects. Drug Deliv. 2016;23(9):2664–71.

Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, et al. Emerging role of microemulsions in cosmetics. Recent Pat Drug Deliv Formul. 2009;3(2):110–7.

Yuan Q, Di J, Huang D, Liu D, Wang X, Zhang L. Water-in-oil microemulsion enhances skin delivery of peptides and proteins. J Control Release. 2011;155(2):302–9.

Chen Y, Liu DZ, Liu P, Xu Y, Zhang H. Microemulsion-based drug delivery systems for oral delivery of peptide and protein drugs: Barriers, strategies, and future prospects. Drug Deliv. 2016;23(9):2664–71.

Sintov AC, Shapiro L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J Control Release. 2003;95(2):173–83.

Santos P, Watkinson AC, Hadgraft J, Lane ME. Application of microemulsions in dermal and transdermal drug delivery. Skin Pharmacol Physiol. 2008;21(5):246–59.

Kaur IP, Smitha R. Penetration enhancers and ocular bioavailability: an update. Drug Dev Ind Pharm. 2004;30(5):593–608.

Narang AS, Delmarre D, Gao D. Stable drug encapsulation in micelles and microemulsions. Int J Pharm. 2011;419(1–2):231–46.

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.

Callender SP, Mathews JA, Kobernyk K, Wettig SD. Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery. Int J Pharm. 2017;526(1–2):425–42.

Marques HMC. A review on microemulsions as drug delivery systems to improve solubility and bioavailability of poorly water-soluble drugs. J Pharm Pharm Sci. 2010;13(4):442–55.

Xu Q, Tsuruta H, Sugiura W, Chen X, Kawakami S. Microemulsions in cancer theranostics. Pharmaceutics. 2023;15(7):1989.

Kogan A, Garti N. Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci. 2006;123–126:369–85.

Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, et al. Emerging role of microemulsions in cosmetics. Recent Pat Drug Deliv Formul. 2009;3(2):110–7.

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.

Danielsson I, Lindman B. The definition of microemulsion. Colloids and Surfaces. 1981;3(4):391–2.

Kawakami K, Yoshikawa T, Moroto Y, Kanaoka E, Takahashi K, Nishihara Y, et al. Microemulsion formulation for enhanced absorption of poorly soluble drugs: I. Prescription design. J Control Release. 2002;81(1–2):65–74.

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.

Attwood D, Florence AT. Surfactant systems: their chemistry, pharmacy and biology. Chapman and Hall. 1994;

Batrakova E V, Li S, Alakhov VY, Miller DW, Kabanov A V. Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter. J Pharmacol Exp Ther. 1998;288(2):665–71.

Attwood D, Florence AT. Surfactant systems: their chemistry, pharmacy and biology. 1994;

Friberg SE. Micelle formation and microemulsions. J Colloid Interface Sci. 1976;55(2):614–23.

Attwood D, Florence AT. Surfactant Systems: Their Chemistry, Pharmacy and Biology. Springer Science & Business Media; 1994.

Shinoda K, Friberg SE. Theory of microemulsion formation. J Colloid Interface Sci. 1973;42(2):381–7.

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.

Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, et al. Emerging role of microemulsions in cosmetics. Recent Pat Drug Deliv Formul. 2009;3(2):110–7.

Porter CJH, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov. 2007;6(3):231–48.

Kogan A, Garti N. Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci. 2007;123–126:369–85.

Zhao X, Zhang T, Wang W, Li Y, Wang S, Liu Y. Influence of oil type on the properties of microemulsions: implications for penetration enhancement. Int J Pharm. 2017;533(2):339–45.

Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rev. 2002;54 Suppl 1:S77–S98.

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.

Constantinides PP, Wasan KM. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995;12(11):1561–72.

Griffin WC. Calculation of HLB values of non-ionic surfactants. J Soc Cosmet Chem. 1954;5:249–56.

Nagarajan R. Molecular packing parameter and surfactant self-assembly: The neglected role of the surfactant tail. Langmuir. 2002;18(1):31–8.

Israelachvili JN, Mitchell DJ, Ninham BW. Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers. J Chem Soc Faraday Trans 2. 1976;72:1525–68.

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.

Tenjarla S. Microemulsions: an overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst. 1999;16(5):461–521.

Heuschkel S, Goepferich A. Microemulsions—modern colloidal carrier for dermal and transdermal drug delivery. J Pharm Sci. 2008;97(2):603–31.

Shinoda K, Friberg SE. Theory of microemulsion formation. J Colloid Interface Sci. 1973;42(2):381–7.

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.

Friberg SE. Micelles, microemulsions, and emulsions. Curr Opin Colloid Interface Sci. 1997;2(4):365–72.

Kumar R, Sharma G, Mehta SK. Microemulsions: Thermodynamic and phase transition aspects. J Mol Liq. 2021;337:116345.

Zhou Q, Shi J, Chu B, Wang Y. Understanding phase inversion in nonionic surfactant-based microemulsions: A review. Colloids Surf A Physicochem Eng Asp. 2020;603:125270.

Heuschkel S, Goepferich A. Microemulsions—modern colloidal carrier for dermal and transdermal drug delivery. J Pharm Sci. 2008;97(2):603–31.

Kumar R, Sharma G, Mehta SK. Microemulsions: Thermodynamic and phase transition aspects. J Mol Liq. 2021;337:116345.

Kumar R, Sharma G, Mehta SK. Microemulsions: Thermodynamic and phase transition aspects. J Mol Liq. 2021;337:116345.

Zhou Q, Shi J, Chu B, Wang Y. Understanding phase inversion in nonionic surfactant-based microemulsions: A review. Colloids Surf A Physicochem Eng Asp. 2020;603:125270.

Chen Y, Zhou Q, Wang Y, He Y. Construction and application of pseudo-ternary phase diagrams in microemulsion formulation development. J Dispers Sci Technol. 2020;41(5):693–702.

Liu Z, Zhu J, Yang Y, Chen H, Lu X. Phase behavior and microstructure characterization of microemulsion systems: Recent advances and perspectives. J Mol Liq. 2021;334:116051.

Moulik SP, Paul BK. Structure, dynamics and transport properties of microemulsions. Adv Colloid Interface Sci. 2001;89–90:349–468.

Chen Y, Zhou Q, Wang Y, He Y. Construction and application of pseudo-ternary phase diagrams in microemulsion formulation development. J Dispers Sci Technol. 2020;41(5):693–702.

Patel MR, Patel RB, Parikh JR, Solanki AB. Investigating effect of microemulsion components: In vitro permeation of ketoprofen through rat skin. Pharm Dev Technol. 2011;16(3):250–8.

Mehta M, Deeksha, Pawar A, Chandel AKS. Microemulsion based topical drug delivery system. J Drug Deliv Sci Technol. 2019;51:475–87.

Shakeel F, Ramadan W, Shafiq S, Khan MA, Alanazi FK. Solubility and thermodynamic function of carvedilol in various co-solvent systems. J Chem Eng Data. 2008;53(6):1336–40.

Kumar R, Sharma G, Mehta SK. Compositional effect on electrical conductivity and phase behavior of microemulsions: Understanding microstructural transitions. J Mol Liq. 2022;352:118697.

Zhou Q, Shi J, Chu B, Wang Y. Understanding phase inversion in nonionic surfactant-based microemulsions: A review. Colloids Surf A Physicochem Eng Asp. 2020;603:125270.

Zemb T, Lu Y, Duvail M. Microemulsions: Structure and dynamics explored with X-ray and neutron scattering. Curr Opin Colloid Interface Sci. 2020;49:1–10.

Hassan PA, Aswal VK, Goyal PS. Recent advances in the characterization of microemulsions using scattering techniques. J Mol Liq. 2023;377:121235.

Gupta R, Jain SK, Varshney M. Shelf life prediction and stability evaluation of nano and microemulsion systems. Colloids Surf B Biointerfaces. 2021;203:111739.

Kaur T, Singh H, Gill B, Saini A. Evaluation of microemulsion characteristics using dynamic light scattering: Particle size and zeta potential insights. J Mol Liq. 2022;347:118373.

Ali MS, Alam MS, Alam N, Siddiqui MR. Preparation, characterization and stability study of dutasteride loaded microemulsion for treatment of benign prostatic hypertrophy. J Mol Liq. 2021;336:116272.

Shakeel F, Ramadan W, Shafiq S. Solubility and dissolution enhancement of poorly water-soluble drugs through microemulsion technique: Recent developments. J Mol Liq. 2021;334:116104.

Khan AW, Kotta S, Ansari SH, Sharma RK, Ali J. Development of nanoemulsion-based drug delivery system for oral bioavailability enhancement of simvastatin. J Dispersion Sci Technol. 2021;42(1):121–31.

Alam MS, Baboota S, Kohli K, Ali J, Ahuja A. Development and evaluation of a microemulsion formulation for transdermal delivery of domperidone. Acta Pharm. 2020;70(3):345–59.

Sharma G, Thakur K, Kaithwas G. Development and evaluation of microemulsion for transdermal delivery of flurbiprofen using modified Franz diffusion cell. J Drug Deliv Sci Technol. 2021;66:102789.

Yadav N, Khatak S, Saraogi GK. Evaluation of in vitro drug release behavior of topical microemulsion formulations using Franz diffusion cell. Pharm Dev Technol. 2020;25(7):806–14. .

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Published

2025-07-16

How to Cite

1.
Patel M, Patel P. A Promising Approach To Deliver Lipophilic Drug Candidate: Microemulsion Based Drug Delivery. J Neonatal Surg [Internet]. 2025Jul.16 [cited 2025Dec.7];13(1):415-26. Available from: https://jneonatalsurg.com/index.php/jns/article/view/8311

Issue

Vol. 13 (2024): Journal of Neonatal Surgery

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Original Article

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