Comparative Study To Evaluate The Efficacy Of Dexmedetomidine (5 Mcg), Nalbuphine (1 Mg), And Magnesium Sulfate (100 Mg) As Adjuvants To 0.75% Hyperbaric Ropivacaine In Subarachnoid Block For Lower Limb Surgery

Authors

  • Tiruvaipathi Lalith V Rama Krishna
  • Griddaluru Sindhura Deepthi
  • Avula Charan Teja Reddy
  • Gunapati Chaitanya Kumar
  • Kandukuru Krishna Chaitanya

Keywords:

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Abstract

Background: Adjuvants to local anaesthetics in subarachnoid block (SAB) enhance anaesthesia quality and prolong analgesia. This study compares dexmedetomidine, nalbuphine, and magnesium sulfate as adjuvants to hyperbaric ropivacaine.

Methods: A randomized, double-blind study was conducted on 90 patients undergoing elective lower limb surgery under SAB. Patients were divided into three groups (n=30): Group D received 5 mcg dexmedetomidine, Group N received 1 mg nalbuphine, Group M received 100 mg magnesium sulfate, each with 3 ml of 0.75% hyperbaric ropivacaine. Onset, duration, regression, analgesia, and adverse effects were recorded.

Results: Dexmedetomidine produced the fastest onset and longest duration of block and analgesia. Nalbuphine was intermediate. Magnesium had delayed onset and shortest duration. Dexmedetomidine caused more bradycardia and hypotension.

Conclusion: Dexmedetomidine is the most effective adjuvant but needs hemodynamic monitoring. Nalbuphine offers a good efficacy-safety balance. Magnesium sulfate is the least effective in this context.

 

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References

Al-Mustafa MM, et al. Saudi Med J. 2009;30(3):365–370.

Gupta R, et al. J Anaesth Clin Pharmacol. 2011;27(3):339–343.

Kanazi GE, et al. Acta Anaesthesiol Scand. 2006;50(2):222–227.

Eid HEA, Shafie MA. Ain-Shams J Anaesthesiol. 2011;4(1):83–95.

Mukherjee A, et al. J Anaesthesiol Clin Pharmacol. 2011;27(1):67–73.

Culebras X, et al. Anesth Analg. 2000;91(3):601–605.

Malleeswaran S, et al. J Obstet Anaesth Crit Care. 2010;1(1):24–27.

Buvanendran A, et al. Anesth Analg. 2002;95(3):661–666.

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Published

2025-07-08

How to Cite

1.
V Rama Krishna TL, Deepthi GS, Reddy ACT, Kumar GC, Chaitanya KK. Comparative Study To Evaluate The Efficacy Of Dexmedetomidine (5 Mcg), Nalbuphine (1 Mg), And Magnesium Sulfate (100 Mg) As Adjuvants To 0.75% Hyperbaric Ropivacaine In Subarachnoid Block For Lower Limb Surgery. J Neonatal Surg [Internet]. 2025Jul.8 [cited 2025Oct.14];14(32S):4166-8. Available from: https://jneonatalsurg.com/index.php/jns/article/view/8089

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

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