Formulation and Evaluation of Gastro- Retentive Floating Tablet in Ulcer Activity
Keywords:
Famotidine, Microballoons, Gastroretentive, Korsmeyer-Peppas, HPMC K4M, peptic, ulcerAbstract
This study developed and evaluated Gastro-retentive famotidine Microballoons for enhanced peptic ulcer treatment. Nine formulations (F1–F9) were prepared using HPMC K4M by emulsion solvent diffusion, varying polymer ratios (1:1–1:3) and stirring speeds (900–1500 rpm). The Microballoons exhibited excellent micromeritic properties (angle of repose: 22.14°–27.19°; Carr’s index: 7.93–13.11%), sustained buoyancy (>12 h, 64.17–83.21%), and high drug encapsulation (63.47–70.34%). FTIR/DSC confirmed drug-excipient compatibility, while SEM revealed porous spherical structures facilitating flotation. In vitro release followed Korsmeyer-Peppas (F1,F4–F5,F7–F9), Higuchi (F2,F6), or zero-order kinetics (F3), with anomalous transport (0.45<n<0.89) predominating. Optimized formulation F3 demonstrated superior performance: highest buoyancy (83.21±1.07%), encapsulation (70.34±0.98%), and zero-order release (R²=0.9954). The system’s prolonged gastric retention and controlled release address famotidine’s short half-life (2.5–4 h), potentially improving therapeutic efficacy in acid-related disorders.
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