Formulation And Evaluation Of Rizatriptan Benzoate Mouth Dissolving Tablets Using Natural Superdisintegrants
DOI:
https://doi.org/10.63682/jns.v14i32S.7940Keywords:
Mouth dissolving tablets, natural super disintegrants, in-vitro release, plantago ovateAbstract
Introduction: Rizatriptan benzoate is a new generation anti-migraine drug, potent and selective 5-hydroxy tryptamine 1B/1D receptor agonist used for the treatment of acute migraine attack. The bioavailability of Rizatriptan benzoate is about 45%. The half-life is 2 to 3 hours. The aim of the study was to formulate Rizatriptan benzoate mouth dissolving tablets (MDT) to enhance the dissolution rate to facilitate quick onset of action.
Methods: Total nine formulations were developed by direct compression method using three natural super-disintegrants. DSC was conducted to study the drug-excipient interaction. All the formulations were subjected for in vitro evaluation tests. Stability study was performed on optimized formulation for 6 months period of time.
Results: All the developed formulations were lies within the pharmacopeia limits. Based on the disintegration time and drug release studies, F3 formulation was selected as optimized formulation. Further, it was subjected for stability studies and was stable for a period of 6 months.
Conclusion: Rizatriptan benzoate mouth dissolving tablets were successfully prepared by the direct compression method using karaya gum, xanthan gum and plantago ovata as superdisintegrants. The optimized formulation (i.e., F3) showed fast disintegration, highest dissolution and was stable for 6 months.
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Avula, P. R., Chettupalli, A. K., Chauhan, V., & Jadi, R. K. (2023). Design, formulation, in-vitro and in-vivo pharmacokinetic evaluation of Nicardipine-nanostructured lipid carrier for transdermal drug delivery system. Materials today: Proceedings.
Banker, G. S., & Rhodes, C. T. (1996). Modern Pharmaceutics, Marcel Dekker. New York, 678-721.
Battu, S. K., Repka, M. A., Majumdar, S., & Rao Y, M. (2007). Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of superdisintegrants. Drug development and industrial pharmacy, 33(11), 1225-1232.
Bi, Y., Sunada, H., Yonezawa, Y., Danjo, K., Otsuka, A., & Iida, K. (1996). Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chemical and pharmaceutical bulletin, 44(11), 2121-2127.
Biradar, S. S., Bhagavati, S. T., & Kuppasad, I. J. (2006). Fast dissolving drug delivery systems: a brief overview. The internet journal of pharmacology, 4(2), 26-30.
Chettupalli, A. K., Ajmera, S., Amarachinta, P. R., Manda, R. M., & Jadi, R. K. (2023). Quality by Design approach for preparation, characterization, and statistical optimization of naproxen sodium-loaded ethosomes via transdermal route. Current Bioactive Compounds, 19(10), 79-98.
Chettupalli, A. K., Kakkerla, A., Jadi, R. K., Uppu, P., Ghazwani, M., Hani, U., ... & Haque, M. A. (2025.a). Design, development, and preclinical evaluation of pirfenidone-loaded nanostructured lipid carriers for pulmonary delivery. Scientific Reports, 15(1), 11390.
Chettupalli, A. K., Unnisa, A., Peddapalli, H., Jadi, R. K., Anusha, K., & Amarachinta, P. R. (2025.b). Development and evaluation of empagliflozin-loaded solid lipid nanoparticles: Pharmacokinetics and pharmacodynamics for oral delivery. Intelligent Pharmacy.
Choudhary NH, Kumbhar MS, Dighe DA, Mujgond PS, Singh MC. Solubility enhancement of escitalopram oxalate using hydrotrope. International Journal of Pharmacy and Pharmaceutical Sciences. 2013;5(1):121-5.
Devprakash, T. R., Gurav, S., Kumar, G. P. S., & Mani, T. T. (2012). An review of phytochemical constituents and pharmacological activity of Plumeria species. Int. J. Curr. Pharm. Res, 4(1), 1-6.
Eslavath, R. N., Bakshi, V., & Jadi, R. K. (2019). Formulation Development and In Vitro Release Studies of Tenofovir-containing Microsponges. INNOSC Theranostics and pharmacological sciences, 2(2), 16-24.
Jadi, R. K., Bomma, R., & Sellappan, V. (2016). Development of a new single unit dosage form of propranolol HCl extended release non-effervescent floating matrix tablets: In vitro and in vivo evaluation. Journal of applied pharmaceutical science, 6(5), 112-118.
Jadi, R. K., Tatikonda, A., Reedy, P. R., & Venisetty, R. K. (2016). Design and characterization of pregabalin swellable core osmotic pumps. Int J Pharm Res Alli, 5, 8-15.
Kalyankar, P., Panzade, P., & Lahoti, S. (2015). Formulation design and optimization of orodispersible tablets of quetiapine fumarate by sublimation method. Indian Journal of Pharmaceutical Sciences, 77(3), 267.
Kannuri R, Chamarthi H, Kumar S, Challa T, Goud A (2011) Formulation development and in-vitro evaluation of escitalopram oxalate orally disintegrating tablets. Int. J. Pharma. Chem. Bio.; 1(1): 57-65.
Komati, S., Dasi, V., Jadi, R. K., & Padala, N. R. (2019). Formulation Development and Characterization of Atazanavir Sulphate Controlled Release Non-Effervescent Floating Matrix Tablets. Journal of Drug Delivery & Therapeutics, 9.
Krymchantowski AV, Bigal ME. Rizatriptan versus rizatriptan plus rofecoxib versus rizatriptan plus tolfenamic acid in the acute treatment of migraine. BMC neurology. 2004 Dec;4:1-6.
Kumar, M. U., & Babu, M. K. (2014). Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant. Asian Pacific journal of tropical biomedicine, 4, S329-S334.
Pandala, S., Bakshi, V., & Jadi, R. K. (2019). Formulation Development and in vitro characterization of zolmitriptan controlled release drug delivery systems. INNOSC Theranostics Pharmacol. Sci, 2(1), 6-11.
Prasad, R. R., Kumar, J. R., Vasudha, B. A. K. S. H. I., & Kumar, C. A. (2018). Formulation development and evaluation of allopurinol solid dispersions by solvent evaporation technique. Int J Appl Pharm, 10(4), 168-171.
Prasanth, V. V., Sarkar, S., Tribedi, S., Mathappan, R., & Mathew, S. T. (2013). Formulation and evaluation of orodispersible tablets of salbutamol sulphate. Res Rev Pharm Pharmaceut Sci, 2, 26-36.
Sapavatu, S. N., & Jadi, R. K. (2019). Formulation development and characterization of gastroretentive drug delivery systems of loratadine. Int. J. Appl. Pharm, 11, 91-99.
Sapavatu, S. N., & Jadi, R. K. (2020). Development of floating drug delivery system for loratadine: in vitro and in vivo evaluation. International journal of pharmaceutical sciences and research, 11, 3021-2.
Sapavatu, S. N., Chinthala, R., & Jadi, R. K. (2020). An overview on pharmacokinetics of polymeric nanoparticles intended for oral delivery. Journal of Young Pharmacists, 12(3)
Shahtalebi, M. A., Tabbakhian, M., & Koosha, S. (2015). Formulation and evaluation of orally disintegrating tablet of ondansetron using natural superdisintegrant. Journal of HerbMed Pharmacology, 4(3), 102-109.
Sharaff, C. S., Renukuntla, P., Peddapalli, H., Kuchukuntla, M., Bakshi, V., & Jadi, R. K. (2024). Formulation, development, and characterization of loratadine emulgel. Journal of Applied Pharmaceutical Research, 12(2), 42-50.
Sheshala R, Khan N, Darwis Y. Formulation and optimization of orally disintegrating tablets of sumatriptan succinate. Chemical and Pharmaceutical Bulletin. 2011 Aug 1;59(8):920-8.
Tiwari, A. K., Shah, H., Rajpoot, A., & Singhal, M. (2011). Formulation and in-vitro evaluation of immediate release tablets of drotaverine HCl. Journal of chemical and pharmaceutical research, 3(4), 333-341.
Togaru, V., Venisetty, R. K., Bakshi, V., & Jadi, R. K. (2017). Formulation Development and In Vitro Evaluation of Propranolol Hydrochloride Extended Release Matrix Tablets. Emergent Life Sciences Research, 3, 38-47.
Wiedey, R., Kokott, M., & Breitkreutz, J. (2021). Orodispersible tablets for pediatric drug delivery: current challenges and recent advances. Expert Opinion on Drug Delivery, 18(12), 1873-1890.
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