Diffusion Tensor Imaging (DTI) in Traumatic Brain Injury: A Systematic Review

Authors

  • Rahul Gangwar
  • Bhrigu Kumar Das
  • Rashmi Singh
  • Shivam Bhardwaj
  • Gurpreet Singh
  • Amit Patra

DOI:

https://doi.org/10.63682/jns.v14i32S.7852

Keywords:

Diffusion Tensor Imaging, Traumatic Brain Injury, Diffuse Axonal Injury, White Matter Integrity, Neuroimaging, Fractional Anisotropy, Mean Diffusivity, Axial Diffusivity, Radial Diffusivity, Tractography

Abstract

Diffusion Tensor Imaging (DTI) is a transformative neuroimaging technique for evaluating traumatic brain injury (TBI),  provides unmatched insights into microstructural alterations and white matter integrity. DTI's  prognostic & diagnostic functions in TBI are examined in this review paper, with a focus on its ability to identify diffuse axonal injury (DAI), a characteristic of TBI that is frequently undetectable by standard imaging. The review highlights the outcomes of contemporary research with an emphasis on the conceptual uses, advantages, and disadvantages of DTI in clinical and scientific contexts. It addresses issues with clinical adoption and offers a thorough, well-supported framework that exins the value of DTI in TBI therapy. [1]

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Menon DK, Schwab K, Wright DW, Maas AI; Demographics and Clinical Assessment Working Group of the International and Interagency Initiative toward Common Data Elements for Research on Traumatic Brain Injury and Psychological Health. Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil. 2010 Nov;91(11):1637-40. doi: 10.1016/j.apmr.2010.05.017. PMID: 21044706.

Jeter CB, Hergenroeder GW, Hylin MJ, Redell JB, Moore AN, Dash PK. Biomarkers for the diagnosis and prognosis of mild traumatic brain injury/concussion. J Neurotrauma. 2013 Apr 15;30(8):657-70. doi: 10.1089/neu.2012.2439. PMID: 23062081.

Basser PJ, Jones DK. Diffusion-tensor MRI: theory, experimental design and data analysis - a technical review. NMR Biomed. 2002 Nov-Dec;15(7-8):456-67. doi: 10.1002/nbm.783. PMID: 12489095.

Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007 Jul;4(3):316-29. doi: 10.1016/j.nurt.2007.05.011. PMID: 17599699; PMCID: PMC2041910.

Shenton ME, Hamoda HM, Schneiderman JS, Bouix S, Pasternak O, Rathi Y, Vu MA, Purohit MP, Helmer K, Koerte I, Lin AP, Westin CF, Kikinis R, Kubicki M, Stern RA, Zafonte R. A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging Behav. 2012 Jun;6(2):137-92. doi: 10.1007/s11682-012-9156-5. PMID: 22438191; PMCID: PMC3803157.

Kraus MF, Susmaras T, Caughlin BP, Walker CJ, Sweeney JA, Little DM. White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain. 2007 Oct;130(Pt 10):2508-19. doi: 10.1093/brain/awm216. Epub 2007 Sep 14. PMID: 17872928.

Hulkower MB, Poliak DB, Rosenbaum SB, Zimmerman ME, Lipton ML. A decade of DTI in traumatic brain injury: 10 years and 100 articles later. AJNR Am J Neuroradiol. 2013 Nov-Dec;34(11):2064-74. doi: 10.3174/ajnr.A3395. Epub 2013 Jan 10. PMID: 23306011; PMCID: PMC7964847.

J Neurol. doi:10.1007/s00415-021-10845-3

J Neurotrauma. doi:10.1089/neu.2019.6832

Geisseler O, Pflugshaupt T, Bezzola L, Reuter K, Weller D, Schuknecht B, Brugger P, Linnebank M. Cortical thinning in the anterior cingulate cortex predicts multiple sclerosis patients' fluency performance in a lateralised manner. Neuroimage Clin. 2015 Nov 14;10:89-95. doi: 10.1016/j.nicl.2015.11.008. PMID: 26759784; PMCID: PMC4683425.

J Neurol Sci. doi:10.1016/j.jns.2023.120128

Mori S, Zhang J. Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron. 2006 Sep 7;51(5):527-39. doi: 10.1016/j.neuron.2006.08.012. PMID: 16950152.

Soares JM, Marques P, Alves V, Sousa N. A hitchhiker's guide to diffusion tensor imaging. Front Neurosci. 2013 Mar 12;7:31. doi: 10.3389/fnins.2013.00031. PMID: 23486659; PMCID: PMC3594764.

Christiaens D, Cordero-Grande L, Pietsch M, Hutter J, Price AN, Hughes EJ, Vecchiato K, Deprez M, Edwards AD, Hajnal JV, Tournier JD. Scattered slice SHARD reconstruction for motion correction in multi-shell diffusion MRI. Neuroimage. 2021 Jan 15;225:117437. doi: 10.1016/j.neuroimage.2020.117437. Epub 2020 Oct 14. PMID: 33068713; PMCID: PMC7779423.

Soares JM, Marques P, Alves V, Sousa N. A hitchhiker's guide to diffusion tensor imaging. Front Neurosci. 2013 Mar 12;7:31. doi: 10.3389/fnins.2013.00031. PMID: 23486659; PMCID: PMC3594764.

Neary-Zajiczek L, Beresna L, Razavi B, Pawar V, Shaw M, Stoyanov D. Minimum resolution requirements of digital pathology images for accurate classification. Med Image Anal. 2023 Oct;89:102891. doi: 10.1016/j.media.2023.102891. Epub 2023 Jul 13. PMID: 37536022.

Cao X, He J, Chen A, Ran J, Li J, Chen D, Zhang H. Comprehensive Analysis of Necroptosis Landscape in Skin Cutaneous Melanoma for Appealing its Implications in Prognosis Estimation and Microenvironment Status. J Pers Med. 2023 Jan 29;13(2):245. doi: 10.3390/jpm13020245. PMID: 36836481; PMCID: PMC9962795.

Neurology. doi:10.1212/WNL.0b013e3181d7b1d2

J Neurotrauma. doi:10.1089/neu.2016.4431

Rutgers DR, Toulgoat F, Cazejust J, Fillard P, Lasjaunias P, Ducreux D. White matter abnormalities in mild traumatic brain injury: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2008 Mar;29(3):514-9. doi: 10.3174/ajnr.A0856. Epub 2007 Nov 26. PMID: 18039754; PMCID: PMC8118864.

Boeddinghaus R, Whyte A. Imaging of Trigeminal Neuralgia and Other Facial Pain. Neuroimaging Clin N Am. 2021 Nov;31(4):485-508. doi: 10.1016/j.nic.2021.05.008. PMID: 34689929.

O'Neil ME, Agyemang A, Walker WC, Pogoda TK, Klyce DW, Perrin PB, Hsu NH, Nguyen H, Presson AP, Cifu DX. Demographic, military, and health comorbidity variables by mild TBI and PTSD status in the LIMBIC-CENC cohort. Brain Inj. 2022 Apr 16;36(5):598-606. doi: 10.1080/02699052.2022.2033847. Epub 2022 Feb 5. PMID: 35125059.

Åkerstedt T, Olsson T, Alfredsson L, Hedström AK. Insufficient sleep during adolescence and risk of multiple sclerosis: results from a Swedish case-control study. J Neurol Neurosurg Psychiatry. 2023 May;94(5):331-336. doi: 10.1136/jnnp-2022-330123. Epub 2023 Jan 23. PMID: 36690431; PMCID: PMC10176406.

Downloads

Published

2025-07-01

How to Cite

1.
Gangwar R, Das BK, Singh R, Bhardwaj S, Singh G, Patra A. Diffusion Tensor Imaging (DTI) in Traumatic Brain Injury: A Systematic Review. J Neonatal Surg [Internet]. 2025Jul.1 [cited 2025Jul.10];14(32S):2928-37. Available from: https://jneonatalsurg.com/index.php/jns/article/view/7852

Similar Articles

You may also start an advanced similarity search for this article.