Global Research Trends on C-Reactive Protein and Periodontitis: A Comprehensive Bibliometric Analysis

Authors

  • Madhu Singh Ratre
  • Deepali Engla
  • Shivani Mishra
  • Veena Kalburgi
  • Shivangi Singh
  • Mitisha Anant Sawant

Keywords:

C-reactive protein, CRP, Periodontitis, Inflammation

Abstract

Introduction: Periodontitis is a chronic inflammatory disease which leads to the progressive destruction of periodontal tissues and is linked to elevated CRP levels in researches. This bibliometric analysis focuses on research landscape indexed in PubMed from 2004 to 2024.

Methods: Articles were extracted from PubMed, and bibliometric data, including titles, authors, institutions, and keywords, were analysed using R programming and R Studio. The search strategy included terms related to periodontitis and CRP.

Results: A total of 231 documents were identified, reflecting significant contributions from the University of Pisa and the University of Catania. Key journals included the Journal of Clinical Periodontology and the Journal of Periodontology. Prominent authors were D’Aiuto F, Orlandi M, and Offenbacher S.

Conclusion: The study highlights the research on CRP and periodontitis, with notable contributions from leading researchers and institutions. It underscores the importance of CRP as a systemic inflammatory marker and its association with periodontitis.

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References

Roberts FA, Darveau RP. Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontol 2000 2015 ;69:18–27.

Ebersole JL, Dawson D, Emecen‐Huja P, Nagarajan R, Howard K, Grady ME, et al. The periodontal war: microbes and immunity. Periodontol 2000 2017;75:52–115.

Wang J, Tan GJ, Han LN, Bai YY, He M, Liu HB. Novel biomarkers for cardiovascular risk prediction. J Geriatr Cardiol 2017;14:135-50.

Cozlea DL, Farcas DM, Nagy A, Keresztesi AA, Tifrea R, Cozlea L, Carașca E. The impact of C reactive protein on global cardiovascular risk on patients with coronary artery disease. Curr Health Sci J 2013;39:225-31.

Teles FR, Chandrasekaran G, Martin L, Patel M, Kallan MJ, Furquim C, et al. Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment. J of Clin Periodontol 2024:1-13.

Freitas COTD, Gomes-Filho IS, Naves RC, Nogueira Filho GDR, Cruz SSD, Santos CADST, et al. Influence of periodontal therapy on C-reactive protein level: a systematic review and meta-analysis. J Appl Oral Sci 2012;20:1–8.

Wohlfeil M, Scharf S, Siegelin Y, Schacher B, Oremek GM, Sauer-Eppel H, et al. Increased systemic elastase and C-reactive protein in aggressive periodontitis (CLOI-D-00160R2). Clin Oral Investig 2012;16:1199–207.

Premnath SM, Nanda SK, Ray L, Arokiaraj MC, Ravichandran K. Association of serum pentraxin 3 and high-sensitivity C-reactive protein with severity of coronary stenosis. Int J Appl Basic Med Res 2022;12:249-53.

Gani D, Lakshmi D, Krishnan R, Emmadi P. Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis. J Indian Soc Periodontol 2009;13:69-74.

R Tutorial [Internet]. [cited 2024 Oct 5]. Available from: https://www.w3schools.com/r/

PubMed [Internet]. [cited 2024 Oct 5]. PubMed. Available from: https://pubmed.ncbi.nlm.nih.gov/

Microsoft Excel 2010 | Download Excel 2010 | Microsoft Office [Internet]. [cited 2024 Oct 5]. Available from: https://www.microsoft.com/en-us/microsoft-365/previous-versions/microsoft-excel-2010

Grolemund G. A Installing R and RStudio | Hands-On Programming with R [Internet]. [cited 2024 Oct 5]. Available from: https://rstudio-education.github.io/hopr/

Machado V, Botelho J, Escalda C, Hussain SB, Luthra S, Mascarenhas P, et al. Serum C-reactive protein and periodontitis: a systematic review and meta-analysis. Front Immunol 2021;12:1-10.

Pope JE, Choy EH. C-reactive protein and implications in rheumatoid arthritis and associated comorbidities. Semin Arthritis Rheum 2021;51;219-29).

Slade GD, Offenbacher S, Beck JD, Heiss G, Pankow JS. Acute-phase Inflammatory Response to Periodontal Disease in the US Population. J Dent Res 2000;79:49–57.

Lee JH, Mun SJ. Relationship between C‐reactive protein level and periodontitis and systemic diseases. J Periodontol 2024;95:494-501.

D’Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, et al. Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers. J Dent Res. 2004;83:156–60.

Ling MR, Chapple ILC, Matthews JB. Neutrophil superoxide release and plasma C‐reactive protein levels pre‐ and post‐periodontal therapy. J Clin Periodontol. 2016;43:652–8.

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Published

2025-06-30

How to Cite

1.
Ratre MS, Engla D, Mishra S, Kalburgi V, Singh S, Sawant MA. Global Research Trends on C-Reactive Protein and Periodontitis: A Comprehensive Bibliometric Analysis. J Neonatal Surg [Internet]. 2025Jun.30 [cited 2025Jul.19];14(32S):2720-3. Available from: https://jneonatalsurg.com/index.php/jns/article/view/7818

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

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