Advancements in Traditional Medicine: Preparation and Characterization of Pomegranate Extract Raft Forming Tablets
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N\AAbstract
The present research work aim was to formulate and evaluate Pomegranate extract raft forming tablets by Direct Compression and Wet Granulation methods. Pomegranate extract is a source of powerful polyphenols that offer potent health support for cardiovascular system. They support healthy blood flow and metabolism, help keep blood pressure within the normal range, and contribute to a balanced inflammatory response. Pectin and guar gum are gel-forming agents used at various concentrations to formulate raft-forming tablets. Upon contact with gastric fluids, they create a viscous, cohesive gel in which each portion swells and merge to form a continuous layer, known as a raft. This raft floats on the gastric fluids due to its low bulk density, which results from the generation of carbon dioxide.
Thus it produces retention of dosage form which enhances gastric retention and prolongs drug delivery within the gastrointestinal tract by remaining buoyant on gastric fluids, allowing for a sustained and controlled drug release at the desired rate. The developed pomegranate raft-forming tablets were thoroughly evaluated for both pre-formulation and post-formulation parameters. FTIR and DSC analyses confirmed the compatibility of pomegranate extract with the selected excipients, indicating no significant interactions. Among all formulations tested, F12 demonstrated superior performance, exhibiting optimal raft weight, minimal buoyancy lag time and the most substantial raft formation. Notably, raft weight increased proportionally with higher concentrations of sodium alginate. Overall, formulation F12 provided the best combination of controlled drug release and floating characteristics compared to the other formulations.
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Bunlung S, Nualnoi T, Issarachot O, Wiwattanapatapee R. Development of raft-formingliquid and chewable tablet formulations incorporating quercetin solid dispersions for treatment of gastric ulcers. Saudi Pharmaceutical Journal. 2021 Oct 1;29(10):1143-54.
Yadav S, Yadav S, Kumar A, Mishra A. Floating Drug Delivery System an Aid to Enhance Dissolution Profile of Gastric. Journal of Drug Delivery and Therapeutics. 2021 Nov 15;11(6):286-96.
Abbas G, Hanif M. Development and pharmacokinetic evaluation of alginate-pectin polymeric rafts forming tablets using box behnken design. Drug Development and Industrial Pharmacy. 2018 Dec 2;44(12):2026-37.
Niu J, Song K, Lim CW. On active vibration isolation of floating raft system. Journal of Sound and Vibration. 2005 Jul 6;285(1-2):391-4068.
Jeganath S. Recent Approaches of Gastroretentive Drug Delivery System–A Review. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm. 2022 Mar 15;16(1).9.
Sanghavi RS, Agrawal O, Usman MR. Gastroretentive Drug Delivery System: An Overview. Research Journal of Pharmacy and Technology. 2022 Mar 24;15(3):1343-7.
Abou Youssef NA, Kassem AA, Magda AbdElsamea EM, Boraie NA. Development of gastroretentive metronidazole floating raft system for targeting Helicobacter pylori. International journal of pharmaceutics. 2015 May 30;486(1-2):297-305.
Kiran CV, Gopinath C. Development and evaluation of interpenetrating polymer network based superporous hydrogel gastroretentive drug delivery systems (SPH IPN-GRDDS). Materials Today: Proceedings. 2021 Jan 1;46:3056-61.
Tripathi J, Thapa P, Maharjan R, Jeong SH. Current state and future perspectives on gastroretentive drug delivery systems. Pharmaceutics. 2019 Apr;11(4):193.
El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA. Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of MebeverineHCl. Drug design, development and therapy. 2017;11:1081.
Panda S, Madhusrota P, Sethi G. Raft orming System-A Novel Approach for Improving Gastric Retention. Journal of PharmaceuticalSciences and Research. 2019 Dec 1;11(12):3761-72.
Shaha SH, Patel JK, Pundarikakshudu K, Patel NV. An overview of a gastro-retentive floating drug delivery system. Asian J Pharm Sci. 2009;4(1):65-80.
Raut SS, Shinde HA. In-situ raft forming system: a review. Int J Pharmacogn. 2018;5(6):337-49.
Bhoyar SM, Ghuge NM, Toshniwal S. Novel approach in floating drug delivery system: raft forming system. J Emerg Technol Innov Res. 2022;9(3):392-403.
Patel R, Vaishnav G. Raft forming system-gastroretentive drug delivery system. Int J Advanced Eng, Manag Sci. 2020;6(12):515-9.
Panza O, Conte A, Del MA. Nobile, “Pomegranate by-products as natural preservative to prolong the shelf life of breaded cod stick,” Molecules.2021; 2(8): 2385-92.
Lawal MV. Modified starches as direct compression excipients–effect of physical and chemical modifications on tablet properties: A review. Starch‐Stärke. 2019 Jan;71(1-2):1800040.
Bhavsar DN. Advances in GRDDS: Raft forming system a review. J drug deliv ther. 2012;2(5):123-8.
Prajapati ST, Mehta AP, Modhia IP, Patel CN. Formulation and optimisation of raft-forming chewable tablets containing H2 antagonist. Int J Pharm Investig. 2012;2(4):176-82.
Rajmane A, Trivedi R, Nandgude T. Formulation and evaluation of raft forming pirenzepinedihydrochloride floating tablets for peptic ulcer. Int J Health Sci. 2022;6(S3):10558–74.
Bunlung S, Nualnoi T, Issarachot O, Wiwattanapatapee R. Development of raft-forming liquid and chewable tablet formulations incorporating quercetin solid dispersions for treatment of gastric ulcers. Saudi Pharm J. 2021;29(10):1143-54.
Ramesh Y, Prasad PV, Saravanakumar K, Sireesha V. Formulation and evaluation of floating drug delivery of cefotaxime using raft forming approach. J Drug Deliv Ther. 2017;7(4):110-9.
Rupavath M, Patnaik K. Development and in vitro characterization gastro retentive raft forming stavudine tablets. Int. J. Pharm. Sci. Drug Res. 2017;9(1):01-9.
Poorvee PB, Dhaval JP. Formulation and evaluation of raft forming gallic acid chewable Tablets for peptic ulcer. Int J Pharm Sci Rev Res. 2018;50(1):68-76.
Hanif M, Shah S, Rasul A, Abbas G, Zaman M, Amjad MW. et.al. Enhancement of oral bioavailability of ibandronate through gastroretentive raft forming drug delivery system: in vitro and in vivo evaluation. Int J Nanomedicine. 2020;15:4847-58.
Soni H, Patel VA. Preparation and evaluation of raft forming chewable tablet of ranitidine hydrochloride. Int J Pharm Res Allied Sci. 2016;59(3):290-6.
Dettmar PW, Little SL, Baxter T. The effect of omeprazole pre-treatment on rafts formed by reflux suppressant tablets containing alginate. J Int Med Res. 2005;33(3):301-8.
Munusamy R, Shanmugasundharam S. Enhanced gastric residence time of acyclovir by floating raft formulation using box-behnken design. Heliyon. 2024; 10: 1-15.
Reddy YSCK , Rao GSNK , Annapurna A , Murthy KVR. Preparation and evaluation of raft forming systems of furosemide. World J Pharm Sci. 2021; 9(4): 34-
Masareddy RS, Panaskar PS. Development and Evaluation of Gastroretentive raft forming tablet of hydrochlorothiazide. World J Pharm Res. 2020; 9(7): 2215-26.
Dahiya J, Jalwal P, Arora S, Singh B, Renu. Formulation and Evaluation of Chewable Tablets of Loratadine by Direct Compression Method. The Pharma Innovation Journal 2015; 4(5): 97-99.
EL-Nabarawi MA, Teaima MH, EL-Monem RAA, EL-Nabarawy NA, Gaber DA. Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl. Drug des dev ther. 2017;11: 1081–93.
Youssef NAHA, Kassem AA, EL-Massik MAE, Boraie NA. Development of gastroretentive metronidazole floating raft system for targeting Helicobacter pylori. Int J Phar. 2015; 486: 297–305.
Manna S, Jayasri K, Annapurna KR, Kanthal LK. Alginate based gastro-retentive raft forming tablets for enhanced bioavailability of tinidazole. Int J App Pharm. 2017; 9(1): 16-21.
Rajput JM. Formulation, optimization and evaluation of in-situ raft-forming suspension of rabeprazole sodium using guar gum. IAJPS. 2022; 9(10): 108-127.
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