In Vitro Antibacterial and Anti Cancerous Activity on Andrographis Paniculata Leaf Extract
Keywords:
Andrographis paniculata, antioxidant, antimicrobial, antiproliferative, phenolic and flavonoid compositionAbstract
Andrographis paniculata, widely recognised as kalmeghor nilavembu, in traditional medicine, is a herb valued for its curative effects in the treatment of persistent health conditions. The study focuses on assessing the bioactive properties of Andrographis Paniculata leaf extracts, particularly its ability to act as an antioxidant and inhibit cancer-related activity.[1] The extracts were assessed for their total phenolic and flavonoid composition. Antimicrobial effectiveness was determined utilizing the well diffusion assay in accordance with the procedure outlined in [2].The ethanol extract displayed antibacterial activity across gram-positive and gram-negative bacterial strains. Furthermore, its antioxidant capability was also significant in vitro, as evidenced by assays including DPPH radical scavenging activity, reducing power assessment, and nitric oxide radical quenching. These antioxidant results were compared against standard compounds like D-ascorbic acid [3]. Importantly, the observed exhibited antiproliferative impact of the ethanol extract on against MCF-7 breast cancer cells underscores its potential therapeautic value in cancer treatment. The presence of compound andrographolide, in A. paniculata, confers antiproliferative properties, which may complement conventional chemotherapy strategies[8].
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