Etiological Spectrum And Antibiotic Resistance Of Uropathogens In Various Forms Of Pyelonephritis: Clinical And Microbiological Research
DOI:
https://doi.org/10.63682/jns.v14i32S.7620Abstract
Pyelonephritis is one of the most common infectious and inflammatory diseases of the urinary system, with a high proportion of hospitalizations and the risk of chronicling the process. The purpose of this study was to analyze the etiological spectrum of pyelonephritis pathogens and determine their sensitivity to the main groups of antibacterial drugs in patients with acute and chronic forms of the disease. The study included 68 patients undergoing inpatient and outpatient treatment. A bacteriological analysis of urine was performed to identify the pathogens and determine their antibiotic sensitivity. It has been established that Escherichia coli remains the dominant pathogen, however, an increase in the proportion of Klebsiella spp., Enterococcus spp. and Pseudomonas aeruginosa is observed. A high degree of resistance to ampicillin, tetracycline and fluoroquinolones has been recorded, especially among nosocomial strains. The optimal first-line drugs are cephalosporins of the third generation and carbapenems. The results obtained confirm the need for regular microbiological monitoring and revision of local empirical therapy regimens, taking into account local resistance.
Downloads
Metrics
References
Kiseleva T.N., Bobkova I.A. Modern approaches to the treatment of urinary tract infections. — Nephrology. 2020. Vol. 24, No. 1. pp. 45-52.
Gorelov A.V., Urazova G.R. Antibiotic resistance: a global problem and national strategies. — Infectious diseases. — 2021. — Vol. 19, No. 2. — pp. 67-74.
Gusev E.I., Kornienko V.N. Urological infections: clinic, diagnosis, treatment. — M.: GEOTAR-Media, 2019. — 328 p.
Kovalev I.V., Sedov A.A. The problem of choosing empirical antibacterial therapy for pyelonephritis. — Russian Medical Journal, 2018, No. 5, pp. 30-35.
European Association of Urology (EAU). Guidelines on Urological Infections. — 2023. — URL: https://uroweb.org/guidelines/urological-infections
Zvereva E.V., Subbotin A.R. Changes in the sensitivity of uropathogens to antibiotics in a hospital setting. — Antibiotics and chemotherapy. — 2020. — Vol. 65, No. 7-8. — pp. 24-30.
WHO. Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report. — Geneva: World Health Organization, 2022. — 98 p.
Prokofieva T.Yu., Smirnov D.A. Biofilms and their role in the development of resistance in chronic pyelonephritis. — Clinical microbiology and antimicrobial chemotherapy. 2019. Vol. 21, No. 3. pp. 202-208.
Zhizhin S.M., Orlova I.A. Chronic pyelonephritis: clinical recommendations and management tactics. — Doctor. — 2021. — No. 10. — pp. 40-45.
Berdnikova N.V., Kuzmina L.P. Microbiological features of uropathogens in women with recurrent pyelonephritis. — Journal of Microbiology, Epidemiology and Immunobiology. - 2022. — No. 4. — pp. 56-62.
Sinyakova L.A. Retsidiviruyushchiye infektsii mochevykh putey: slozhnosti up- roshchennoy diagnostiki. [Recurrent Urinary Tract Infections: the Complexity of a Simplified Diagnosis] / L.A. Sinyakova // Urologiya segodnya [Urology Today]. — 2013. — 1. — P. 3-7.
Kameneva O.A. Etiologicheskaya struktura i antibiotikorezistentnost' vozbuditeley vnebol'nichnykh infektsiy mochevyvodyashchikh putey v Sankt-Peterburge, 2013-2015. [Etiological Structure and Antibiotic Resistance of Pathogens of Community-Acquired Infections of the Urinary Tract in St. Petersburg, 2013-2015] / O.A. Kameneva, S.E. Morozova, O.E. Punchenko [et al.] // Antibiotiki i khimioterapiya [Antibiotics and Chemotherapy]. — 2017. — 62(9-10). — P. 19-26.
Palagin I.S. Sovremennoye sostoyaniye antibiotikorezistentnosti vozbuditeley vnebol'nichnykh infektsiy mochevykh putey v Rossii: rezul'taty issledovaniya «DARMIS» (2010-2011). [Current State of Antibiotic Resistance of Pathogens Causing Community- Acquired Urinary Tract Infections in Russia: "DARMIS" Study (2010–2011)] / I.S. Palagin, M.V. Suhorukova, A.V. Dekhnich [et al.] // Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya [Clinical Microbiology and Antimicrobial Chemotherapy]. — 2012. — 14(4). — P. 280-302.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Abdullaeva Aida Muradovna, Kerimova Kabira Asimovna, Dibiraliev Akhmed Shamilevich, Abdulsemedova Jamilya Abdulsemedovna, Nabieva Leila Fikretovna, Ramazanova Muminat Mutalimovna, Dibirova Aminat Mansurovna, Shahmardanova Kamila Imamovna, Magomedova Maryam Mahachevna, Magomedov Alibek Abdulkasumovich
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
