A Comprehenssive Review On Guava Plant; Nutritional Composition , Potential Pharmacological Activities
Keywords:
Guava seeds, Bioactive compounds, pharmacological activities, Functional food properties, commercial applicationsAbstract
In countries that are tropical or subtropical, a common food crop and medicinal plant,Psidium guajava is also utilised in traditional medicine all around the world. This seeks to provide thorough understanding of the pharmacological, clinical, and chemical components. A wide range of in vivo and in vitro models have been employed for pharmacological investigations. Important phyto-constituents for medicine have also been found. Several metabolites in good yield, primarily from the phenolic, flavonid, carotenoid, terpenoid, and triterpene groups, have been demonstrated to have beneficial biological actions. This plant's metabolites and extracts, especially those derived from the leaves and fruits, have beneficial pharmacological properties. Because of its antispasmodic and antibacterial properties, P. guajava is mostly used to treat diarrhoea and dysentery, according to a review of the literature. has also been used extensively as a hypoglycemic agent. Numerous pharmacological studies have demonstrated the antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic, antispasmodic, vigorous, cough suppressant, antidiabetic, anti-inflammatory, and antinociceptive qualities of this plant, thereby substantiating its traditional uses. Provide a variety of clinical uses for the treatment of diabetes, diarrhoea, and infantile rotaviralenteritis.
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Parvez GM, Shakib U, Khokon M, Sanzia M. A short review on a nutritional fruit: guava. Open Access: Toxicology and Research. 2018;1:1-8.
Lim YY, Lim TT, Tee JJ. Antioxidant properties of guava fruit: comparison with some local fruits. Sunway Academic Journal. 2006;3:9-20.
Singh SP. Guava (Psidium guajava L.). Postharvest biology and technology of tropical and subtropical fruits. 2011 Jan 1:213-46e.
Joseph B, Priya M. Review on nutritional, medicinal and pharmacological properties of guava (Psidium guajava Linn.). International Journal of pharma and bio sciences. 2011 Jan;2(1):53-69.
Parvez GM, Shakib U, Khokon M, Sanzia M. A short review on a nutritional fruit: guava. Open Access: Toxicology and Research. 2018;1:1-8.
Joseph B, Priya M. Review on nutritional, medicinal and pharmacological properties of guava (Psidium guajava Linn.). International Journal of pharma and bio sciences. 2011 Jan;2(1):53-69.
Sahu, S. K., Barman, K., & Singh, A. K. (2020). Nitric oxide application for postharvest quality retention of guava fruits. Acta Physiologiae Plantarum, 42(10), 156. https://doi.org/10.1007/s11738-020-03143-8.
Narv´aez-Cuenca, C. E., Inampues-Charfuelan, M. L., Hurtado-Benavides, A. M., Parada- Alfonso, F., & Vincken, J. P. (2020). The phenolic compounds, tocopherols, and phytosterols in the edible oil of guava (Psidium guava) seeds obtained by supercritical CO2 extraction. Journal of Food Composition and Analysis, 89, Article 103467. https:// doi.org/10.1016/j.jfca.2020.103467.
Ling, C. X., & Chang, Y. P. (2017). Valorizing guava (Psidium guajava L.) seeds through germination-induced carbohydrate changes. Journal of Food Science and Technology, 54(7), 2041–2049. https://doi.org/10.1007/s13197-017-2641-5.
Darmasiwi, S., Herawati, O., & Retnaningrum, E. (2018). Edible biofilm formation from guava seed waste fermentation. Digital Press Physical Sciences and Engineering, 1, 00005. https://doi.org/10.29037/digitalpress.11244.
Nishad, J., Dutta, A., Saha, S., Rudra, S. G., Varghese, E., Sharma, R. R., … Kaur, C. (2021). Ultrasound-assisted development of stable grapefruit peel polyphenolic nano-emulsion: Optimization and application in improving oxidative stability ofmustard oil. Food Chemistry, 334, Article 127561.
Kumar, M., Tomar, M., Amarowicz, R., Saurabh, V., Nair, M. S., Maheshwari, C., Sasi, M., Prajapati, U., Hasan, M., Singh, S., Changan, S., Prajapat, R. K., Berwal, M. K., & Satankar, V. (2021a). Guava (Psidium guajava L.) leaves: Nutritional composition, phytochemical profile, and health-promoting bioactivities. Foods, 10(4), 752. https://doi.org/10.3390/foods10040752.
Punia, S., & Kumar, M. (2021). Litchi (Litchi chinenis) seed: Nutritional profile, bioactivities, and its industrial applications. Trends in Food Science & Technology, 108, 58–70.
Bangar, S. P., Kumar, M., & Whiteside, W. S. (2021). Mango seed starch: A sustainable and eco-friendly alternative to increasing industrial requirements. International Journal of Biological Macromolecules, 183, 1807–1817.
Dinesh MR, Reddy BMC. Physiological basis of growth and fruit yield characteristics of tropical and sub-tropical fruits to temperature. Tropical Fruit Tree Species and Climate Change 2012, 45.
Singh SP. Guava (Psidium guajava L.). Postharvest biology and technology of tropical and subtropical fruits. 2011, 213-246e.
Birdi T, Krishnan GG, Kataria S, Gholkar M, Daswani P. A randomized open label efficacy clinical trial of oral guava leaf decoction in patients with acute infectious diarrhoea. Journal of Ayurveda and integrative medicine. 2020;11(2):163-172.
Sehrawat SK, Dhankhar SS, Pannu RK. ICAR-JRF (PGS). 2014.
Singh SP. Guava (Psidium guajava L.). Postharvest biology and technology of tropical and subtropical fruits. 2011, 213-246e.
Paull RE, Duarte O. Tropical fruits. 2012;2(Ed.2):CABI.ix + 371 pp. http://www.cabi.org/cabebooks/ebook/20123357661 doi:10.1079/9781845937898.0000 .
Kocher GS. Status of wine production from guava (Psidium guajava L.): A traditional fruit of India. African Journal of Food Science 2011;5(16):851-860.
Kadam DM, Kaushik P, Kumar R. Evaluation of guava products quality. International Journal of Food Science and Nutrition Engineering 2012;2(1):7-11.
Rahman TU, Amanullah NT, Tahir A, Rahman AU, Khan A. Evaluation and preparation of guava jam stored at ambient temperature. Pure and Applied Biology (PAB) 2018;7(3):1064-1073.
Jolhe P, Sahu GD, Kumar V. Preparation and evaluation of guava jelly (Psidium guajava). Journal of Pharmacognosy and Phytochemistry 2020;9(6):2061-2063.
Kuchi VS, Gupta R, Tamang S. Standardization of recipe for preparation of guava jelly bar. Journal of crop and weed. 2014;10(2):77-81.
26. Sevda SB, Rodrigues L. Fermentative behavior of Saccharomyces strains during guava (Psidium guajava L) must fermentation and optimization of guava wine production. J Food Process Technol 2011;2(118):2.
Kanwal N, Randhawa MA, Iqbal Z. A review of production, losses and processing technologies of guava. Asian Journal of Agriculture and Food Sciences. 2016;4(2).
Kaneko K, Suzuki K, Iwadate‐Iwata E, Kato I, Uchida K, Onoue M. Evaluation of food–drug interaction of guava leaf tea. Phytotherapy Research 2013;27(2):299-305.
Ponnuchamy M, Kapoor A, Pakkirisamy B, Sivaraman P, Ramasamy K. Optimization, equilibrium, kinetic and thermodynamic studies on adsorptive remediation of phenol onto natural guava leaf powder. Environmental Science and Pollution Research 2019, 1-22.
Uchôa-thomaz AMA, Sousa EC, Carioca JOB, Morais SMD, Lima AD, Martins CG, et al. Chemical composition, fatty acid profile and bioactive compounds of guava seeds (Psidium guajava L.). Food Science and Technology. 2014;34(3):485-492.
Maurya AK, Pandey RK. Influence of Guava Seed Powder Fortification on Physicochemical, Textural and Sensory Properties of Biscuits.
Omayio DG, Abong GO, Okoth MW, Gachuiri CK, Mwang’ombe AW. Current Status of Guava (Psidium Guajava L) Production, Utilization, Processing and Preservation in Kenya: A Review. Current Agriculture Research Journal 2019;7(3):318.
Denny C, Melo PS, Franchin M, Massarioli AP, Bergamaschi KB, de Alencar SM, Rosalen PL. Guava pomace: a new source of anti-inflammatory and analgesic bioactives. BMC complementary and alternative medicine 2013;13(1):1-7.
Tangirala S, Sarkar BC, Sharma HK, Kumar N. Modeling and characterization of blended guava pomace and pulse powder based rice extrudates. International Journal of Food Engineering 2012;8(1):1-24.
Gan, C. Y., & Latiff, A. A. (2011). Extraction of antioxidant pectic-polysaccharide from mangosteen (Garcinia mangostana) rind: Optimization using response surface methodology. Carbohydrate Polymers, 83(2), 600–607.
Tongdang, T. (2008). Some properties of starch extracted from three Thai aromatic fruit seeds. Starch - St¨arke, 60(3–4), 199–207.
Thiyagarajan A, Rathnasamy VK, Veerasamy B, Sangeetha VS, Vellaichamy J, Subbian M. GUAVA (Psidium Guajava L.) SEED: A REVIEW ON NUTRITIONAL PROFILE, BIOACTIVE COMPOUNDS, FUNCTIONAL FOOD PROPERTIES, HEALTH BENEFITS AND INDUSTRIAL APPLICATIONS.
Yamatoya, K., Tabuchi, A., Suzuki, Y., & Yamada, H. (2020). Tamarind seed polysaccharide. In Biopolymer-Based Formulations (pp. 445–461). Elsevier. Doi: 10.1016/B978-0-12-816897-4.00020-5.
Treichel, M., Kist, B. B., Santos, C. D., Carvalho, C. D., & Beling, R. R. (2016). Anu´ario brasileiro da fruticultura (p. 88). Santa Cruz Do Sul: Editora Gazeta.
Bernardino-Nicanor, A., Ortiz Moreno, A., Martinez Ayala, A. L., D´avila Ortíz, G., Nicanor, A. B., Moreno, A. O., Ayala, A. L. M., & Ortíz, G. D. (2001). Guava seed protein isolate: Functional and nutritional characterization. Journal of Food Biochemistry, 25(1), 77–90.
Mechmeche, M., Kachouri, F., Chouabi, M., Ksontini, H., Setti, K., & Hamdi, M. (2017). Optimization of extraction parameters of protein isolate from tomato seed using response surface methodology. Food Analytical Methods, 10(3), 809–819.
Durante, M., Montefusco, A., Marrese, P. P., Soccio, M., Pastore, D., Piro, G., Mita, G., & Lenucci, M. S. (2017). Seeds of pomegranate, tomato and grapes: An underestimated source of natural bioactive molecules and antioxidants from agri-food by-products. Journal of Food Composition and Analysis, 63, 65–72.
Isik, F., & Yapar, A. (2017). Effect of tomato seed supplementation on chemical and nutritional properties of tarhana. Journal of Food Measurement and Characterization, 11(2), 667–674
Kapoor, S., Gandhi, N., Tyagi, S. K., Kaur, A., & Mahajan, B. V. C. (2020). Extraction and characterization of guava seed oil: A novel industrial byproduct. LWT, 132, Article 109882.
Arain, A., Sherazi, S. T. H., Mahesar, S. A., & Sirajuddin. (2017). Spectroscopic and chromatographic evaluation of solvent extracted guava seed oil. International Journal of Food Properties, 20(sup1), S556–S563.
Iha, O. K., Martins, G. B. C., Ehlert, E., Montenegro, M. A., Sucupira, R. R., & Suarez, P. A. Z. (2018). Extraction and characterization of passion fruit and guava oils from industrial residual seeds and their application as biofuels. Journal of the Brazilian Chemical Society, 29(10), 2089–2095.
Samiha Kabir S, Jahan SM, Hossain MH, Siddique R. Apple, guava and pineapple fruit extracts as antimicrobial agents against pathogenic bacteria. Am J Microbiol Res. 2017;5(5):101–6.
Prasad, N. B. L., & Azeemoddin, G. (1994). Characteristics and composition of guava (Psidium guajava L.) seed and oil. Journal of the American Oil Chemists’ Society, 71(4), 457–458.
Piombo, G., Barouh, N., Barea, B., Boulanger, R., Brat, P., Pina, M., & Villeneuve, P. (2006). Characterization of the seed oils from kiwi (Actinidia chinensis), passion fruit (Passiflora edulis) and guava (Psidium guajava). Ol´eagineux, Corps Gras, Lipides, 13 (2–3), 195–199.
Prommaban, A., Utama-ang, N., Chaikitwattana, A., Uthaipibull, C., Porter, J. B., & Srichairatanakool, S. (2020). Phytosterol, lipid and phenolic composition, and biological activities of guava seed oil. Molecules, 25(11), 2474.
Ramsden, C. E., Zamora, D., Leelarthaepin, B., Majchrzak-Hong, S. F., Faurot, K. R., Suchindran, C. M., Ringel, A., Davis, J. M., & Hibbeln, J. R. (2013). Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: Evaluation of recovered data from the Sydney Diet Heart Study and updated metaanalysis. BMJ (Online), 346(7894).
Rockenbach, I. I., Rodrigues, E., Gonzaga, L. V., & Fett, R. (2010). Fatty acid composition of grape (Vitis vinifera L. and Vitis labrusca L.) seed oil. Brazilian Journal of Food Technology, 3, 23–26.
Mariamenatu, A. H., & Abdu, E. M. (2021). Overconsumption of omega-6 polyunsaturated fatty acids (PUFAs) versus deficiency of omega-3 PUFAs in modernday diets: The disturbing factor for their “balanced antagonistic metabolic functions” in the human body. Journal of Lipids, 2021, 1–15.
Sokoła-Wysocza´nska, E., Wysocza´nski, T., Wagner, J., Czy˙ z, K., Bodkowski, R., Lochy´nski, S., & Patkowska-Sokoła, B. (2018). Polyunsaturated fatty acids and their potential therapeutic role in cardiovascular system disorders—a review. Nutrients, 10(10), 1561.
Shao X, Ning L, Lai D, Xiao W, Zhuang Q, Qin J, Chen J. Lipidomic profiling of guava cultivars by UPLC/MS Q-TOF analysis. Scientia Horticulturae. 2025 Feb 15;342:114058.
Manzoor E, Ghani A, Khan MR, Sultana M, Ishaque A, Nasir E, Latif MF, Riaz T, Sohail A. Antioxidant potential of guava leaves extracts and their effects on hyperlipidemia. Annals of Plant Sciences. 2019;8(5):3553-62.
Kobori, C. N., & Jorge, N. (2005). Caracterizaç˜ao dos ´oleos de algumas sementes de frutas como aproveitamento de resíduos industriais. Ciˆencia e Agrotecnologia, 29(5), 1008–1014.
Elias A. The Effect Of Psidium Guava Leaf Extract On Blood Pressure In Guinea Pigs, and Weight, Lipid Profiles and Serum Liver Enzymes in Fructose Fed Swiss Albino Mice. Addis Ababa University. 2014 Oct.
Ferrari, R. A., Colussi, F., & Ayub, R. A. (2004). Caracterizaç˜ao de subprodutos da industrializaç˜ao do maracuj´a-aproveitamento das sementes. Revista Brasileira de Fruticultura, 26(1), 101–102.
Lima, R. da S., Ferreira, S. R. S., Vitali, L., & Block, J. M. (2019). May the superfruit red guava and its processing waste be a potential ingredient in functional foods? Food Research International, 115, 451–459.
Prommaban, A., Utama-ang, N., Chaikitwattana, A., Uthaipibull, C., & Srichairatanakool, S. (2019). Linoleic acid-rich guava seed oil: Safety and bioactivity. Phytotherapy Research, 33(10), 2749–2764.
Guidoni, M., De Christo Scherer, M. M., Figueira, M. M., Schmitt, E. F. P., De Almeida, L. C., Scherer, R., Bogusz, S., & Fronza, M. (2019). Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications. Brazilian Journal of Medical and Biological Research, 52(2).
63-Kumari S, Rakavi R, Mangaraj M. Effect of guava in blood glucose and lipid profile in healthy human subjects: a randomized controlled study. Journal of clinical and diagnostic research: JCDR. 2016 Sep 1;10(9):BC04.
Ziboh, V. A., Cho, Y., Mani, I., & Xi, S. (2002). Biological significance of essential fatty acids/prostanoids/lipoxygenase- derived monohydroxy fatty acids in the skin. Archives of Pharmacal Research, 25(6), 747–758.
Uchˆoa-thomaz, A. M. A., Sousa, E. C., Carioca, J. O. B., De Morais, S. M., Lima, A. D., Martins, C. G., Alexandrino, C. D., Ferreira, P. A. T., Rodrigues, A. L. M., Rodrigues, S. P., Thomaz, J. C. D. A., Silva, J. D. N., & Rodrigues, L. L. (2014). Chemical composition, fatty acid profile and bioactive compounds of guava seeds (Psidium guajava L.). Food Science and Technology, Campinas, 34(3), 485–492.
Berger, A., Jones, P. J. H., & Abumweis, S. S. (2004). Plant sterols: Factors affecting their efficacy and safety as functional food ingredients. Lipids in Health and Disease, 3, 5.
Narv´aez-Cuenca, C. E., Inampues-Charfuelan, M. L., Hurtado-Benavides, A. M., Parada- Alfonso, F., & Vincken, J. P. (2020). The phenolic compounds, tocopherols, and phytosterols in the edible oil of guava (Psidium guava) seeds obtained by supercritical CO2 extraction. Journal of Food Composition and Analysis, 89, Article 103467.
Castera-Rossignol, A., & Bosque, F. (1994). Nouvelle approche des anti-oxydants. OCL. Ol´eagineux, Corps Gras, Lipides, 1(2), 131–143.
El Anany, A. M. (2015). Nutritional composition, antinutritional factors, bioactive compounds and antioxidant activity of guava seeds (Psidium myrtaceae) as affected by roasting processes. Journal of Food Science and Technology, 52(4), 2175–2183.
Ram, S., Narwal, S., Gupta, O. P., Pandey, V., & Singh, G. P. (2020). In Anti-nutritional factors and bioavailability: approaches, challenges, and opportunities (pp. 101–128). Elsevier.
Chang, Y. P., Tan, M. P., Lok, W. L., Pakianathan, S., & Supramaniam, Y. (2014). Making use of guava seed (Psidium guajava L): The effects of pre-treatments on its chemical composition. Plant Foods for Human Nutrition, 69(1), 43–49.
Deguchi Y, Miyazaki K. Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract. Nutr Metab (Lond). 2010;7:9.
Anand V, Manikandan KV, Kumar S, Pushpa HA. Phytopharmacological overview of Psidium guajava Linn. Phcog J. 2016;8:314–20.
Conde Garcia EA, Nascimento VT, Santiago Santos AB. Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the Guinea pig atrium. Brazilian J Med Biol Res. 2003;36(5):661–8.
Rai PK, Mehta S, Watal G. Hypolipidaemic & hepatoprotective effects of Psidium guajava raw fruit peel in experimental diabetes. Indian J Med Res. 2010;131:820–4.
Jaiarj P, Khoohaswan P, Wongkrajang Y, Peungvicha P, Suriyawong P, Sumal Saraya ML, et al. Anticough and antimicrobial activities of Psidium guajava Linn. Leaf extract. J Ethnopharmacol. 1999;67(2):203–12.
Joseph B, Priya RM. Phytochemical and biopharmaceutical aspects of Psidium guajava (L.) essential oil: a review. Res J Med Plant. 2011;5(4):432–42.
Limsong J, Benjavongkulchai E, Kuvatanasuchati J. Inhibitory effect of some herbal extracts on adherence of Streptococcus mutans. J Ethnopharmacol. 2004;92:281–9.
Melo C, Cornejal N, Cruz V, Alsaidi S, Rodriguez GC, Ramirez AG, Sorel V, Bonnaire T, Zydowsky TM, Priano C, Romero JF. Antioxidant capacity and antimicrobial activity of commercial samples of guava leaves (Psidium guajava). Journal of Medicinally Active Plants. 2020 Mar 31;9(1).
Rattanachaikunsopon P, Phumkhachorn P. Contents and antibacterial activity of flavonoids extracted from leaves of Psidium guajava. J Med Plants Res. 2010;4(5):393–6.
Anas K, Jayasree PR, Vijayakumar T, Kumar PRM. In vitro antibacterial activity of Psidium guajava Linn. Leaf extract on clinical isolates of multidrug resistant Staphylococcus aureus. Indian J Exp Biol. 2008;46(1):41–6.
Nair R, Chanda S. In-vitro antimicrobial activity of psidium guajava l . Leaf extracts against clinically important pathogenic microbial strains. Braz J Microbiol. 2007;38:452–8.
Banu MS, Sujatha K. Antimicrobial screening of leaf extract of Psidium guajava and its isolated fraction against some pathogenic microorganisms. Drug Invent Today. 2012;4(3):348–50.
Gonçalves FA, Neto MA, Bezerra JNS, Macrae A, De SOV. Antibacterial activity of guava , psidium guajava linnaeus , leaf extracts on diarrheacausing enteric bacteria isolated from seabob shrimp, Xiphopenaeus kroyeri (Heller). Rev. Inst. Med. trop. S. Paulo. 2008;50(1):11–5.
Chen Y, Zhou T, Zhang Y, Zou Z, Wang F, Xu D. Evaluation of antioxidant and anticancer activities of guava. Int J Food Nutr Saf. 2015;6(1):1–9.
Puntawong S, Okonogi S, Pringproa K. In vitro antibacterial activity of Psidium guajava Linn. Leaf extracts against pathogenic bacteria in pigs. Chiang Mai Univ. J Nat Sci. 2012;11(2):127–34.
Adhami VM, Khan N, Mukhtar H. Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr Cancer. 2009;61(6):811–5 8.
Al-Zoreky NS. Antimicrobial activity of pomegranate (Punicagranatum L.) fruit peels. Int J Food Microbiol. 2009;134:244–8.
Afroja S, Falgunee FN, Jahan MK, Akanda KM, Mehjabin S, Parvez GMM. Antibacterial activity of different citrus fruits. Specialty journal of medical research and health. Science. 2017;2(1):25–32.
S M, Hegde AU, N.S S, T.R PK. Antimicrobial activity of Citrus Sinensis and Citrus Aurantium Peel extracts. J pharm sci innov. 2014;3(4):366.
Samiha Kabir S, Jahan SM, Hossain MH, Siddique R. Apple, guava and pineapple fruit extracts as antimicrobial agents against pathogenic bacteria. Am J Microbiol Res. 2017;5(5):101–6.
Venkatesan N, Thiyagarajan V, Narayanan S, Arul A, Raja S, Kumar SGV, Rajarajan T, Perianayagam JB. Antidiarrheal potential of Asparagus racemous wild root extracts in laboratoire animals. J Pharm Pharmaceut Sci. 2005;8:39–45.
Teixeira RDO, Camparoto ML, Mantovani MS. Assessment of two medicinal plants , Psidium guajava L. and Achillea millefolium L., in in vitro and in vivo assays. Genet Mol Biol. 2003;555:551–5.
Vieira RHSF, Rodrigues DP, Gonçalves FA, Menezes FGR, Aragoo JS, Sousa OV. Microbicidal effect of medicinal plant extracts (Psidium guajava linn. And Carica papaya linn.) upon bacteria isolated from fish muscle and known to induce dirrhea in children. Rev Inst Med trop S Paulo. 2001;43:145–8.
Tonal L, Kambu K, Mesial K, Cimanga K, Totte J, Vlietinck AJ. Biological screening of traditional preparations from some medicinal plants used as antidiarrhoeal in Kinshasa, Congo. Phytomedicine. 1999;6(1):59–66.
Shaheen HM, Ali BH, Alqarawi AA, Bashir AK. Effect of Psidium guajava leaves on some aspects of the central nervous system in mice. Phyther Res. 2000;14(2):107–11.
Ojewole J, Awe EO, Chiwororo WDH. Antidiarrhoeal activity of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rodents. J Smooth Muscle Res. 2008;44(6):195–207.
Mazumdar S, Akter R, Talukder D. Antidiabetic and antidiarrhoeal effects on ethanolic extract of Psidium guajava (L.) bat. Leaves in Wister rats. Asian Pac J Trop Biomed. 2015;5(1):10–4.
Birdi T, Daswani P, Brijesh S, Tetali P, Natu A, Antia N. Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea. BMC Complement Altern Med. 2010;10:33.
Jeong S, Cho SK, Ahn KS, Lee JH, Yang DC, Kim J. Anti-inflammatory effects of an ethanolic extract of guava (Psidium guajava L.) leaves in vitro and in vivo. J Med Food. 2014;17(6):678–85.
Matsuzaki K, Ishii R, Kobiyama K. New benzophenone and quercetin galloyl glycosides from Psidium guajava L. J Nat Med. 2010;64:252–6. 55. Denny C, Melo PS, Franchin M, Massarioli AP, Bergamaschi KB, Alencar SM De, et al. Guava pomace : a new source of anti-inflammatory and analgesic bioactives. 2013.
He Q, Venant N. Antioxidant power of phytochemicals from Psidium guajava leaf. J Zhejiang Univ Sci A. 2004;5(6):676–83.
Roy CK, Kamath JV, Asad M. Hepatoprotective activity of Psidium guajava Linn. leaf extract. Indian J Exp Biol. 2006;44(4):305–11.
Masuda T, Inaba Y, Maekawa T, Takeda Y, Yamaguchi H, Nakamoto K, Kuninaga H, Nishizato S, Nonaka A. Simple detection method of powerful antiradical compounds in the raw extract of plants and its application for the identification of antiradical plant constituents. J Agric Food Chem. 2003;51:1831–8.
103. Musa KH, Abdullah A, Jusoh K, Subramaniam V. Antioxidant activity of pinkflesh guava (Psidium guajava l.): effect of extraction techniques and solvents. Food Anal Methods. 2011;4:100–7.
Feskanich D, Ziegler RG, Michaud DS, Giovannucci EL, Speizer FE, Willett WC, Colditz GA. Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. J Natl Cancer Inst. 2000;92:1812–23.
Fleuriet A, Macheix JJ. Phenolic acids in fruits and vegetables. In C. A. RiceEvans & L. packer, flavonoids in health and disease. New York: Marcel Dekker Inc.; 2003.
Koo MH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin and apigenin) content of edible tropical plants. J Agri Food Chem. 2001;49:3106–12.
Seo J, Lee S, Elam ML, Johnson SA, Kang J, Arjmandi BH. Study to find the best extraction solvent for use with guava leaves (Psidium guajava L.) for high antioxidant efficacy. Food Sci Nutr. 2014;2:174–80.
Thaipong K, Boonprakob U, Cisneros-zevallos L, Byrne DH, Pathom N. Hydrophilic and lipophilic antioxidant activities of guava fruits. Southeast Asian J Trop Med Public Health. 2005;36:254–7.
Fernandes MRV, Azzolini AECS, Martinez MLL, Souza CRF, Oliveira WP. Assessment of antioxidant activity of spray dried extracts of psidium guajava leaves by dpph and chemiluminescence inhibition in human neutrophils. Biomed Res Int. 2014;2014:382891 Article ID 382891.
Santhoshkumar T, Rahuman AA, Jayaseelan C, Rajakumar G, Marimuthu S, Kirthi AV, Valayutham K, Thomas J, Venkatesan J, Kim S. Green synthesis of titanium dioxide nanoparticles using Psidium guajava extract and its antibacterial and antioxidant properties Green synthesis of titanium dioxide nanoparticles using Psidium guajava extract and its antibacterial and antioxidant properties. Asian Pac J Trop Biomed. 2014;7:968–76.
Vijayakumar K, Anand AV, Manikandan R. In vitro antioxidant activity of Ethanolic extract of Psidium guajava leaves. Int J Res Stud Biosci. 2015; 3(5):145–9.
Manikandan R, Anand AV. Evaluation of antioxidant activity of psidium guajava Linn . In streptozotocin – induced diabetic rats. Free Radicals Antioxid. 2016;6(1):72–6.
Nantitanon W, Okonogi S. Comparison of antioxidant activity of compounds isolated from guava leaves and a stability study of the most active compound. Drug Discov Ther. 2012;6(1):38–43.
Soman S, Rauf AA, Indira M, Rajamanickam C. Antioxidant and Antiglycative potential of ethyl acetate fraction of Psidium guajava leaf extract in Streptozotocin-induced diabetic rats. Plant Foods Hum Nutr. 2010;65:386–91.
Ekaluo UB, Ikpeme EV, Ekerette EE, Chukwu CI. In vitro antioxidant and free radical activity of some Nigerian medicinal plants: bitter leaf (Vernonia amygdalina L.) and guava (Psidium guajava Del.). Research Journal of Medicinal Plant. 2015;9(5):215-26.
Birdi TJ, Brijes S, Daswani PG. Bactericidal effect of selected antidiarrhoeal medicinal plants on intracellular heat-stable enterotoxin-producing Escherichia coli. Indian journal of pharmaceutical sciences 2014; 76(3):229.
Daswani PG, Gholkar MS, Birdi TJ. Psidium guajava: A single plant for multiple health problems of rural Indian population. Pharmacognosy reviews 2017;11(22):167.
Lee WC, Mahmud R, Noordin R, Pillai Piaru S, Perumal S, Ismail S. Free radicals scavenging activity, cytotoxicity and anti-parasitic activity of essential oil of Psidium guajava L. leaves against Toxoplasma gondii. Journal of Essential Oil Bearing Plants 2013;16(1):32-38.
Ravi K, Divyashree P. Psidium guajava: A review on its potential as an adjunct in treating periodontal disease. Pharmacognosy reviews 2014;8(16):96.
Mittal P, Gupta V, Kaur G, Garg A, Singh A. Phytochemistry and pharmacological activities of Psidium guajava. IJPSR 2010;1(9):9-19.
Abdullah MS, Nas FS, Ali M. Antibacterial activity of Psidium guajava leaf and stem bark extracts against clinical isolates of Staphylococcus aureus and Salmonella typhi. Int. J. Res. Pharm. Biosciences. 2019;6(5):11-7.
Motamedi Zadeh B, Haghighi G. The Antibacterial properties of psidium guava to eliminate Helicobacter pylori: Preventing Gastric Cancer. Multidisciplinary Cancer Investigation. 2024 Feb 10;8(1):0-.
George A. Phytochemical Screening And Antimcrobial Efficacy of Leaf Extract Of Guava (Psidium guajava) On Selected Bacteria. International Journal of Contemporary Microbiology. 2024 Jul 1;10(2).
Fitri Kusuma SA, Tanzillafitsi N, Resmiati M. Comparative study on antibacterial effects of ethanolic leaf extracts of guava in variants of red and white pulp (Psidium guajava) against sensitive and chloramphenicol-resistant Staphylococcus aureus. Drug Invention Today. 2019 Jul 1;11(7).
Alam A, Jawaid T, Alsanad SM, Kamal M, Balaha MF. Composition, antibacterial efficacy, and anticancer activity of essential oil extracted from Psidium guajava (L.) leaves. Plants. 2023 Jan 5;12(2):246.
Kafle A, Mohapatra SS, Reddy I, Chapagain M. A review on medicinal properties of Psidium guajava. Journal of Medicinal Plants 2018;6(4):44-47.
Fasola TR, Oloyede GK, Bello SI. Phytochemical investigation of guava (Psidium guajava Linn.) Stem bark for haematological indices in albino swiss rats. EJEAF Che 2012;11(4):315-327.
Saravani S, Ghaffari M, Aali H. Hydroalcoholic extract of Psidium guajava plant and bone marrow cells: examination and analysis of effects. Cellular, Molecular and Biomedical Reports. 2024 Sep 1;4(3):177-88.
Qadan, F., Thewaini, A.J., Ali, D.A., Afifi, R., Elkhawad, A., Matalka, K.Z., 2005. The antimicrobial activities of Psidium guajava and Juglans regialeaf extracts to acne-developing organisms. American Chinese Medical 33, 197–204.
Razak, F.A., Othman, R.Y., Rahim, Z.H., 2006. The effect of Piper betle and Psidium guajava extracts on the cell-surface hydrophobicity of selected early settlers of dental plaque. Journal of Oral Science 48, 71–75.
Yadav A, Honamane P, Rajput M, Dange V, Salunkhe K, Kane S, Mohite S. Antimalarial activity of Psidium guajava leaf extracts. Int J Sci Res Chemi. 2020 Nov;5(6):63-8.
Akkawi M, Abu-Lafi S, Abu-Remeleh Q, Lutgen P. Screening of guava (Psidium guajava) leaves extracts against β-hematin formation. Pharm Pharmacol Int J. 2021;9(1):11-5.
Cesar PH, Trento MV, Oliveira DA, Simão AA, Vieira LF, Marcussi S. Prospection of effects of guava leaves infusion: Antigenotoxic action and enzymatic inhibition. Natural Product Communications. 2017 Jun;12(6):1934578X1701200631.
Zahin M, Ahmad I, Aqil F. Antioxidant and antimutagenic potential of Psidium guajava leaf extracts. Drug and chemical toxicology. 2017 Apr 3;40(2):146-53.
Andrade-Vieira LF, Palmieri MJ, Botelho CM, Luber J, Silva MF. Evaluation of the antimutagenic potential of Psidium guajava L. extracts via plant bioassays. South African Journal of Botany. 2017 Nov 1;113:443-8.
Lee H, Eo Y, Kim SY, Lim Y. Guava leaf extract attenuated muscle proteolysis in dexamethasone induced muscle atrophic mice via ubiquitin proteasome system, mTOR-autophagy, and apoptosis pathway. Nutrition Research. 2024 Jul 1;127:97-107.).
Babatola LJ, Oboh G, Ademiluyi AO. Toxicological evaluation of aqueous extract of different varieties of guava (Psidium guajava Linn) leaves. Comparative Clinical Pathology. 2019 Dec;28:1689-97.
Koshak AE. Prevalence of herbal medicines in patients with chronic allergic disorders in Western Saudi Arabia. Saudi medical journal. 2019;40(4):391.
Swer Tl, Rani S, & Bashir K. Manufacturing Of Jams, Jellies, And Marmalades From Fruits And Vegetables. Processing of Fruits and Vegetables: From Farm to Fork 2019, 59.
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