Effect of Omega-3 Fatty Acids on the Lipid Profile in Rats induced-acute cardiotoxicity by doxorubicin
Keywords:
Doxorubicin, heart toxicity .lipids, Omega-3Abstract
Doxorubicin is a medication used to treat various cancers .One of the side effects of doxorubicin is cardio toxicity. Some studies have shown that omega 3 has a protective effect against doxorubicin cardio-toxicity. Also, many studies suggested there is effect of Omega-3 supplement on lipids profile. Therefore, This study aimed to evaluate the lipids profile after receiving Omega-3 in rats induced-acute cardiotoxicity by doxorubicin. The rats were divided into five groups: the first group was given normal saline, the second group was given doxorubicin, the third group was given 100 mg of OMG, the fourth group was given 200 mg of OMG, and the fifth group was given 400 mg of Omega-3. After 4 weeks, 20mg doxorubicin was given for all groups except normal saline group. Serum obtained after 48 h. lipid profile was measured according to manufacturer of company using spectrophotometer. Regarding present data, mean level of Cholesterol, triglyceride, LDL and VLDL were reduced In omg3 groups (100mg,200mg,400mg) significantly. While HDL was increased. Conclusion: The lipids profile has been better (low levels) when use Omega-3in rats induced- acute cardiotoxicity by doxorubicin. Thus, Omega-3 may consider as protective supplement in heart toxicity.
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