Evaluation of Acute Toxicity Study of Ethanolic Extract of Koelreuteria Paniculata Laxm in Albino Wistar Rats
DOI:
https://doi.org/10.63682/jns.v14i31S.7233Keywords:
OECD, Genotoxicity, Acute Toxicity Studies, Antihypertensive, Antineoplastic, AntioxidantAbstract
Koelreuteria paniculata, also named as golden rain tree, indigenous to China and other Asian countries. The current study examines its potential benefits in treating a variety of pharmacological disorders, including genotoxicity, antihypertensive, antioxidant, oxidative stress, antimalarial, and antineoplastic conditions. According to OECD guideline 423, acute toxicity studies examine the efficacious of the medicinal plant (Koelreuteria paniculata) and are helpful for further in vivo and in vitro investigations of other pharmacological illnesses.
Downloads
Metrics
References
Dosmann MS, Whitlow TH, Ho-Duck K. The (un) natural and cultural history of Korean goldenrain tree. insula. 1936;1915:2.
Santamour FS, Spongberg SA. 'Rose Lantern': A New Cultivar of Koelreuteria paniculata, the Golden-Rain Tree. Arnoldia. 1996 Jul 1;56(2):32-7.
Britannica E. Britannica concise encyclopedia. Encyclopaedia Britannica. 2017 Sept(9): 15-17.
Sutiashvili MG, Alaniya MD, Mshvildadze VD, Skhirtladze AV, Pichette A, Lavoie S, et al. Flavonoid and cycloartane glycosides from seeds of Koelreuteria paniculata. Chemistry of Natural Compounds. 2013 May;49:395-7.
Wang Y, Zheng D, Zhao Y, Wang T, Yang Y, Ashraf MA, Peng W, et al. Active components in branches and leaves of Koelreuteria paniculata. Caribbean Journal of Science. 2018;51(1):11-21.
Sutiashvili MG, Alaniya MD, Mshvildadze VD, Skhirtladze AV, Pichette A, Lavoie S, et al. Flavonoid and cycloartane glycosides from seeds of Koelreuteria paniculata. Chemistry of Natural Compounds. 2013 May;49:395-7.
Ljubojević, M.; Tomić, M.; Simikić, M.; Savin, L.; Narandžić, T.; Pušić, M.; Grubač, M.; Vejnović, S.; Marinković,et al. M. Koelreuteria paniculata Invasiveness, Yielding Capacity and Harvest Date Influence on Biodiesel Feedstock Properties. J. Environ. Manag. 2021, 295, 113102
Chunyi T, Wen D, Zhongsong G. The total flavon extraction from fruits, branchs, leaves of the Koelreuteria paniculate laxm and it, s content determination. Zhongguo Nong xue Tong bao= Chinese Agricultural Science Bulletin. 2005 Jan 1;21(5):159-63.
Wang Y, Liu Q, Zheng D, Zhao Y, Wang T, Yan S, Gu H, et al. Active constituents of Koelreuteria paniculata root. Thermal Science. 2020;24(3 Part A):1737-44.
Thaipong K, Boonprakob U, Crosby K, Cisneros-Zevallos L, Byrne DH, et al. Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts. Journal of food composition and analysis. 2006 Sep 1;19(6-7):669-75.
Kumar M, Chandel M, Kumar S, Kaur S. Studies on the antioxidant/genoprotective activity of extracts of Koelreuteria paniculata laxm. Am. J. Biomed. Sci. 2012;1:177-89.
Andonova T, Muhovski Y, Fidan H, Slavov I, Stoyanova A, Dimitrova-Dyulgerova I, et al. Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from Koelreuteria paniculata Laxm. Plants. 2021 Dec 10;10(12):2715
Chung YC, Chang CT, Chao WW, Lin CF, Chou ST. Antioxidative activity and safety of the 50 ethanolic extract from red bean fermented by Bacillus subtilis IMR-NK1. Journal of agricultural and food chemistry. 2002 Apr 10;50(8):2454-8.Ghahari S, Alinezhad H, Nematzadeh GA, Ghahari S. Phytochemical screening and antimicrobial activities of the constituents isolated from Koelreuteria paniculata leaves. Natural product research. 2015 Oct 2;29(19):1865-9.
Mostafa AE, Atef A, Mohammad AE, Cutler SJ, Ross SA, et al. New triterpenoidal saponins from Koelreuteria paniculata. Phytochemistry letters. 2016 Sep 1;17:213-8.
Thapa R, Goyal A, Gupta G, Bhat AA, Singh SK, Subramaniyan V, Sharma S, Prasher P, Jakhmola V, Singh SK, Dua K, et al. Recent developments in the role of protocatechuic acid in neurodegenerative disorders. EXCLI journal. 2023;22:595.
Lu X, Sun L, Zhang Y, Li W. New barrigenol-type triterpenoids with anti-Alzheimer’s disease activity from Koelreuteria paniculata Laxm. Journal of Functional Foods. 2019 Oct 1;61:103459.
Wang D, Hu P, Tie N. Responses of photosynthesis and antioxidant activities in Koelreuteria paniculata young plants exposed to manganese stress. South African Journal of Botany. 2022 Jul 1;147:340-8.
Zhelev I, Georgiev K, Dimitrova-Dyulgerova I. In-vitro antioxidant and antineoplastic activities of carotenoids from flowers of Koelreuteria paniculata. World J. Pharm. Res. 2016 Mar 2;5:53-60.
Kumar M, Chandel M, Kumar S, Kaur S. Protective effects of Koelreuteria paniculata Laxm. on oxidative stress and hydrogen peroxide-induced DNA damage. Phytopharmacology. 2011;1(5):177-89.
Nafees S, Akhtar J, Kaur J. Indian traditional medicinal plants in ophthalmic diseases. Avicenna journal of phytomedicine. 2022 Nov;12(6):566.
Cao Y, Xie L, Liu K, Liang Y, Dai X, Wang X, Lu J, Zhang X, Li X, et al. The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review. Pharmacological research. 2021 Dec 1;174:105919.
Malik A, Jamil U, Butt TT, Waquar S, Gan SH, Shafique H, Jafar TH, et al. In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model. Drug design, development and therapy. 2019 May 6:1501-13.
Shankar TB, Shantha NV, Ramesh HP, Murthy IA, Murthy VS, et al. Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guineapigs and monkeys.
Njue LG, Ombui JN, Kanja LW, Gathumbi JK, Nduhiu JG. Evaluation of oral toxicity level of ethyl acetate extract, from garlic (allium sativum) in onorrh dawleys rats as per OECD guidelines 423.
Jarald EE, Joshi SB, Jain DC. Antidiabetic activity of flower buds of Michelia champaca Linn. Indian Journal of Pharmacology. 2008 Nov 1;40(6):256
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
