Formulation and Evaluation of Floating Microspheres of Lamotrigine
Abstract
Floating drug delivery systems are one of the innovative medication delivery technologies that are now available. Because the bulk density of a floating medication delivery system is lower than that of gastric fluids, it is able to maintain its buoyancy in the stomach without making a significant impact on the pace at which the stomach empties for an extended length of time. Ethyl cellulose and Eudragit S 100 were used as polymers in the process of manufacturing floating microspheres of lamotrigine. This was accomplished by the emulsion solvent evaporation mechanism. The micrometric features of the floating microspheres were investigated, including their particle size, % yield, in-vitro buoyancy, incorporation efficiency, drug polymer compatibility (infrared research), scanning electron microscopy, and in-vitro drug release. The results demonstrate that the particle size, percentage yield, in-vitro buoyancy, and in-vitro drug release of microspheres are all affected by the concentration of polymer, which rises as the concentration level increases. Additionally, it was discovered that the cumulative drug release using a distinct ethyl cellulose 3:1 A-5 drug:polymer ratio at 900 rpm speed was shown to be more effective than another ratio. It was discovered that the micromeritic property was satisfactory, and scanning electron microscopy revealed that the structure was hollow, with a smooth surface, and that the percentage of drug release was ninety percent over a period of twelve hours. The results of this investigation indicate that floating microspheres containing lamotrigine have the potential to provide prolonged drug delivery, which may result in a reduction in the number of times required to provide a dose
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