Relationship Between Interleukin 8 Levels And Body Mass Index In Patients With Endometrial Cancer
Keywords:
body mass index, endometrial carcinoma, interleukin-8, obesityAbstract
Introduction: Increased body mass index (BMI) is one of the risk factors for endometriosis cancer associated with chronic inflammatory processes that can be confirmed by increased inflammatory markers in obese patients such as interleukin 8 (IL-8). This study aims to evaluate the relationship between IL-8 levels to body mass index and clinicopathological characteristics of patients with endometrial carcinoma.
Methods: This was cross-sectional study that conducted from November 2022 to February 2023 in Endometrial Cancer. Demographic and clinicopathological data were collected. BMI and IL-8 serum were measured. Data were analyzed with SPSS 27.0, using the Mann-Whitney test, Kruskal Wallis test and Spearman correlation test.
Results: Lymphovascular Space Invasion (LVSI) and stage were not significantly associated with IL-8 levels (p>0.05). IL-8 levels were higher in obese patients than in non-obese patients but not statistically significant (p>0.05). Endometrial carcinoma type was significantly associated with IL-8 levels (p<0.05). Higher age was significantly associated with higher IL-8 levels (p<0.05).
Conclusion: Obesity was not correlated to IL-8 levels in endometrial carcinoma patients, but IL-8 levels are influenced by age and type of endometrial carcinoma.
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References
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424.
Hazelwood E, Sanderson E, Tan VY, et al. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis. BMC Med 2022; 20: 1–24.
Ciortea R, Mihu D, Mihu CM. Association between visceral fat, IL-8 and endometrial cancer. Anticancer Res 2014; 34: 379–383.
Ewington L, Taylor A, Sriraksa R, et al. The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma. Cytokine 2012; 59: 417–422.
Ray I, Meira LB, Michael A, et al. Adipocytokines and disease progression in endometrial cancer: a systematic review. Springer US. Epub ahead of print 2022. DOI: 10.1007/s10555-021-10002-6.
Bǎlǎşoiu M, Bǎlǎşoiu AT, Mogoantǎ SŞ, et al. Serum and tumor microenvironment IL-8 values in different stages of colorectal cancer. Rom J Morphol Embryol 2014; 55: 575–578.
Roškar L, Pušić M, Roškar I, et al. Models including preoperative plasma levels of angiogenic factors, leptin and IL-8 as potential biomarkers of endometrial cancer. Front Oncol 2022; 12: 1–15.
Ellis PE, Barron GA, Bermano G. Adipocytokines and their relationship to endometrial cancer risk: A systematic review and meta-analysis. Gynecol Oncol 2020; 158: 507–516.
Mochizuki K, Oishi N, Kawai M, et al. Expressions of il-8 and cxcl5 in uterine endometrioid carcinomas which have frequent neutrophil infiltration and comparison to colorectal adenocarcinoma. Histol Histopathol 2020; 35: 1503–1510.
Deng Y, Ning Z, Hu Z, et al. High interleukin-8 and/or extracellular signal-regulated kinase 2 expression predicts poor prognosis in patients with hepatocellular carcinoma. Oncol Lett 2019; 18: 5215–5224.
Fousek K, Horn LA, Palena C. Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression. Pharmacol Ther 2021; 219: 107692.
Moku P, Shepherd L, Ali SM, et al. Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial. Cancer 2020; 126: 4859–4866.
Kliemann N, Viallon V, Murphy N, et al. Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition. BMC Med 2021; 19: 1–14.
Ostrowska L, Gornowicz A, Pietraszewska B, et al. Which salivary components can differentiate metabolic obesity? PLoS One 2020; 15: 1–10.
van den Bosch AAS, Pijnenborg JMA, Romano A, et al. The role of fat distribution and inflammation in the origin of endometrial cancer, study protocol of the ENDOCRINE study. PLoS One 2022; 17: 1–9.
Grandi G, Perrone AM, Chiossi G, et al. Increasing BMI is associated with both endometrioid and serous histotypes among endometrial rather than ovarian cancers: a case-to-case study. Gynecol Oncol 2019; 154: 163–168.
Tiainen L, Hämäläinen M, Luukkaala T, et al. Low Plasma IL-8 Levels During Chemotherapy Are Predictive of Excellent Long-Term Survival in Metastatic Breast Cancer. Clin Breast Cancer 2019; 19: e522–e533.
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