Sumatriptan Mucoadhesive Buccal Tablet for the Treatment of Migraine

Authors

  • Shivani Prajapati
  • Sarfaraz Ahmed

Keywords:

N/A

Abstract

In this review , we assessed a buccal sumatriptan formulation specifically for migraine treatment. This abstract provides a concise overview of the key aspects and applications of mucoadhesive buccal tablets of sumatriptan.

The primary objective of mucoadhesive buccal tablet is to enhance the bioavailability and therapeutic efficacy of drugs by enabling controlled and sustained release directly into the bloodstream.

In this article, we will delve into the concept, development, and applications of mucoadhesive buccal tablet highlighting their key features and benefits in the treatment of migraine.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Khan, J. et al. (2021) “Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine,” Biomedecine & pharmacotherapie [Biomedicine & pharmacotherapy], 139(111557), p. 111557. Available at https://doi.org/10.1016/j.biopha.2021.111557.

Pescador Ruschel, M.A. and De Jesus, O. (2025) “Migraine headache,” in StatPearls. Treasure Island (FL): StatPearls Publishing.

Lew, C. and Punnapuzha, S. (2025) “Migraine medications,” in StatPearls. Treasure Island (FL): StatPearls Publishing.

Gandhi S., Pandya P., Umbarkar R., Tambawala T., Shah M. (2011), Mucoadhesive Drug Delivery System- An Unusual Maneuver for Site Specific Drug Delivery System, Int J of Pharm Sci., 2:132- 152.

Shojaei Amir H. (2003), Buccal Mucosa as A Route for Systemic Drug Delivery: A Review, J Pharm Pharm Sci., 1(1):15-33.

AN ASSESSMENT ON BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Marketed-products-of-BDDS-formulation_tbl3_356130485

Ahuja, A., Khar, R. K. and Ali, J. “Mucoadhesive gastro intestinal drug delivery system: an overview", Drug. Dev. Ind. Pharm., Vol. 23, No. 5, pp. 489-515, 1997.

Aungst, A. "Permeability and metabolism as barriers to transmucosal delivery of peptides and proteins", Drug Permeation Enhancement, Theory and Applications, Marcel Dekker, New York, Vol. 1, pp. 323- 343, 1994

Balamurugan, K., Pandit, J. K., Choudary, P. K. and Balasubramaniam, J. "Systemic absorption of propranolol hydrochloride from buccoadhesive films", d. J. Pharm. Sci., Vol. 63, No. 6, pp. 473-480, 2001.

Barsuhn, C. L., Planoff, L. S., Gleason, D. D, Adkins, E. L. and Ho, N. F. H. "Human buccal absorption of flurbiprofen", Clin. Pharmacol. Ther., Vol. 44, No. 2, pp. 225-231, 1988

Batchelor, H. "Novel bioadhesive formulations in drug delivery", The drug delivery company report. Research and Markets: Dublin, Ireland. Autumn / Winter, pp. 16-19, 2004.

Castellaneous, J. M. R., Zia, H. and Rhodes, C. T. "Mucoadhesive drug delivery systems", Drug. Dev. Ind. Pharm., Vol. 19, No. 1-2, pp. 143-194, 1993.

Chattarajee, S. C. and Walker, R. B. "Penetration enhancer classification", Percutaneous Penetration Enhancement, CRC Press, Boca Raton, 1995.

Ganem, A., Falson, R. and Buri, P. "Mechanisms of oral permeation enhancement", Eur. J. Drug Metab. Pharmacokinet, Vol. 111, pp. 112-123, 1996

Goud, K., Desai, H. and Pramod, K. T. M. "Preparation and evaluation of a novel buccal adhesive system", AAPS Pharm SciTech., Vol. 5, No. 3, pp. 1-9, 2004.

Gupta, A., Garg, S. and Khar, R. K. "Mucoadhesive drug delivery systems: a review", Ind. Drugs., Vol. 29, No. 13, pp. 586-593, 1992.

Haesun, P. and Joseph, R. R. "Mechanisms of bioadhesion of poly (acrylic acid) hydrogels", Pharm. Res., Vol. 4, No.6, pp. 457-464, 1987.

Han, R. Y., Fang, J. Y., Sung, K. C. and Hu, O. Y. "Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery: effect of formulation variables on drug release and mucoadhesive performance", Int. J. Pharm., Vol. 177, No. 2, pp. 201-209, 1999.

Downloads

Published

2025-06-02

How to Cite

1.
Prajapati S, Ahmed S. Sumatriptan Mucoadhesive Buccal Tablet for the Treatment of Migraine. J Neonatal Surg [Internet]. 2025Jun.2 [cited 2025Nov.2];14(30S):170-4. Available from: https://jneonatalsurg.com/index.php/jns/article/view/6931

Issue

Vol. 14 No. 30S (2025): Journal of Neonatal Surgery

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  • Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.