Formulation and Evaluation of Terbinafine HCL loaded Nanoparticles for Transungual delivery of drug in Fungal infection
DOI:
https://doi.org/10.63682/jns.v14i28S.6615Keywords:
Transungual, Nail Lacquer, Porosis, Pseudomonas bacterial infection, and OnchomycosisAbstract
In this review we mainly concern about the transungual delivery of drug to treat nail infection which is caused by the infection of a fungus. Transungual drug delivery is regarded as a very desirable treatment for various diseases in nail treatment due to its localized effects, which promote adherence while causing less unfavorable systemic effects. The nail is one of the toughest portions of the human body, and the nail plate presents a challenging barrier for drugs moiety to pass through . Topical medication delivery treatment is useful for treating numerous nail problems since it has localized effects, resulting in less systemic side effects and a better outcome. As compare to oral drug delivery the transungual delivery of drug is more effective it act on targeted site, increase the penetration, improve bio-availability and show rapid action. So for the transungual delivery of a drug there are many formulations such as gel, cream, patches, lotion, and nail lacquer etc.As compare to oral drug delivery the transungual delivery is viscous preparation used as a cosmetic items or to decor our nail of finger and toes. It is more stable formulation for longer use. On the basis of above conclusion nail lacquer is used in transungul drug delivery with addition of nanoparticle (drug loaded) and as cosmetic item to enhance beauty of the nail. The recent advancement on delivery of drug through nail system has lead to the development of anti-fungal nail lacquer.
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Rathi R Apeksha , Popat Ritesh R , Adhao S Vaibhav, Shrikhande N Vinayak ; Nail drug delivery system a review; International Journal of Pharmaceutical Chemistry and Analysis, 2020;7(1):2-21.
Verma Surender, Singh Renu and Ashima ; Transungual drug delivery a pivotal remedy in onychomycosis ; Journal of Chemical and Pharmaceutical Research, 2016, 8(4):370-381.
Rajendra .B Vivek, Baro Anjana, Kumari Abha,. Dhamecha . L Dinesh , Lahoti R Swaroop, Santosh D. Shelke . D Santosh; Transungual Drug Delivery an Overview; Journal of Applied Pharmaceutical Science 2012: 02 (01); 203-209.
Nikam. K Vikrant, Kotad . B Kiran, Gaware. M Vinayak, Dolas.T Raamdas,Kiran B Dhamak3, Sachin B Somwanshi1, Khadse . N Atul, Vivekanand A. Kashid . A Vivekanand ; transungual drug delivery system: a review; pharmacologyonlin 2011( 1)126-139
Sharma Lalit , Mehan Navneet , Chouhan Ritika , Anjali Suman , Kumar Vaibhav , KM Rekha , Kumar Kunal and Kumar Naman ; Current review on nail drug delivery system and their future perspectives; World Journal of Biology Pharmacy and Health Sciences, 2024, 19(01), 337-349.
V . Aneesha , S.Gopi, Jose Jaison Rasel , S. Karan, M. Snehadevi, Jeevanandham Dr. S, and Akshara V.Anil ; formulation and evaluation of herbal antifungal nail lacquer for the treatment of onychomycosis; world journal of pharmaceutical research; 2024 ;vol 13, Issue 1.
Chandra Ram, Kumar Sandeep, Aggarwal Ashutosh; Evaluation of Nail Lacquer; Indo Global Journal of Pharmaceutical Sciences, 2012; 2(4): 379-382.
Vejnovic, I., Simmler, L ., Betz G., “Investigation of different formulations for drug delivery through the nail plate”, International Journal of Pharmaceutics, 2010, 386, 185-194.
Kesharwani1 Roohi, Sachan Anupam, Singh Swati, Patel Dilip ; Formulation and Evaluation of Solid Lipid Nanoparticle (SLN) Based Topical Gel of Etoricoxib; Journal of Applied Pharmaceutical Science Vol. 6 (10), 2016 ;124-131.
Upadhyay Prerna, Kaur Manjit, Choudhary Akanksha , Kujar Shaina , Nita. Dr. Transungal Drug Delivery System: A Review on Bharti Gupta; Int. J. Pharm. Sci. Rev. Res., 57(2), 2019; 50-56.
Muthukumar .M, Prabhu R, Rajeev. T , Arunpandiyan J, Thaila R, Jayalakshmi B, Senthilraja M. ;Formulation Development of Antimicrobial Nail Lacquer by Transungual Delivery System for the Treatment of Paronychia; International Journal of Pharmaceutical Sciences Review and Research; 2023; 167-175
Bhattacharjee Bedanta, Dey Nikita, Barman Dhunusmita, Karmakar Arka, Ahmed Nasima; Understanding the drug delivery through nails: a comprehensive review; Journal of Drug Delivery & Therapeutics. 2021; 11(4):116-131
Azhar Danish Khan, Ayan Giri , Lubhan Singh; transungual drug delivery: a newer approach; world journal of pharmacy and pharmaceutical sciences; 2014; vol 3, issue 3
Kumar T. Praveen, Raju P. Narayana; Transungual Drug Delivery ; A Promising Route to Treat Nail Disorders; International Journal of Pharma Research & Review, 2013; 2(4):22-33.
Vaghasiya Harshad, Kumar Abhinesh , Sawant Krutika; Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride; 2013, Volume 49, Issue 2, 311-322.
Julia A. Balfour & Diana Faulds ;Terbinafine; A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Superficial 1992,Volume 43, 259–284.
Aditya K. Gupta MD, , Neil H. Shear MD; Terbinafine: An update Journal of the American Academy of Dermatology; 1997, Volume 37, Issue 6 , 979-988.
Abobakr E Fatna ,Fayez M. Sahar, Elwazza S.Vivian , Srkran Wedad; formulation and optimization of terbinafine hcl solid lipid nanoparticlesfor topical antifungal activity; international journal of pharmacy and pharmaceutical Sciences; 2019 Vol 11.
Tiwari S, Mistry P and Patel V; SLNs Based on Co-Processed Lipids for Topical Delivery of Terbinafine Hydrochloride; Journal of Pharmaceutics & Drug Development; 2020 Volume 2 227-234.
Fatma E. Abobakr, Sahar M. Fayez, Vivian S. Elwazzan, Wedad Sakran; Effect of Different Nail Penetration Enhancers in Solid Lipid Nanoparticles Containing Terbinafine Hydrochloride for Treatment of Onychomycosis; AAPS PharmSciTech ;2021;22:33.
Bhapkar P.H, Puttewar T.Y ,Patil .R.Y , Nail Lacquers in Nail Diseases, IOSR Journal Of Pharmacy; 2013 ; Issue 9 ; Volume 3; 24-48.
Deshmukh.S Priya, Kadam .A Aniket ; Drug Delivery through Nail Bed - A Novelistic Platform; Ijppr.Human, 2022; Vol. 23 (4): 472-491.
Yadav.Vikas, Srivastava1.Viashal , Dwivedi . Karunakar Parsad, Singh. Ravindra, Yadav. Anku Verma. Kumar Navneet; A review on disease of nails (fungal infection), diagnosis & treatment (nail lacquer); World journal of pharmacy and pharmaceutical sciences; 2022;Volume 11, Issue 10; 663-694.
Verma. Surender, Shweta Rani. Shweta , Yadav. Akash; A review on an emanation of nail lacquer in the management of nail disorders; World Journal of Pharmaceutical Research;2020; Volume 10, Issue 1, 870-898.
Rathi1 .R. Apeksha, Popat. .R .Rutesg, Adhao. S.Vaubhav , Shrikhande. N.Vinayak; Nail drug delivery system a review; International Journal of Pharmaceutical Chemistry and Analysis; 2020;7(1) ;9-21
Salunke Pramod Rutuja, Ingale Vilas Minal, Shinde Dadasaheb Nikita , Pingale Rajendra Vaishnavi and Kumbhar Umesh Akanksha; a comprehensive review on nail lacquer; World Journal of Pharmaceutical ; 2023 Volume 12, Issue 9, 2378-2390 .
V. Malvade V. Pratik . , Chavan . R .Sayli , Bhagat . B Dhanashri , Ghorpade . R. Komal ; transungual: the novel drug delivery system ; World Journal of Pharmaceutical and Life Sciences; 2020, Vol. 6, Issue 6, 265-274
Sharma .Sonal , Chopra Hitesh , Pahwa Rakesh, Talha B. Emran B. Talha ; Novel transungual drug delivery system for treating Onychomycosis ; International Journal of Surgery 2023; 109; 2145–2147
Pradnya Suryabhan , Gaikwad Rutuja V. Pagare; An Overview on Transungual Drug Delivery System; transungual drug delivery: a newer approach ; International Journal of Pharmaceutical Research and Applications ;2023 Volume 8;464-478
Zahra Salehi & Masoomeh Shams-Ghahfarokhi,; Mehdi Razzaghi-Abyaneh ; Antifungal drug susceptibility profile of clinically important dermatophytes and determination of point mutations in terbinafine-resistant isolates; European Journal of Clinical Microbiology & Infectious Diseases ;2018; 37;1841–1846
Tiwari S, Mistry P and Patel V; SLNs Based on Co-Processed Lipids for Topical Delivery of Terbinafine Hydrochloride; Journal of Pharmaceutics & Drug Development; 2014;V 2; 2348-9782
Duong An-Van, Nguyen Linh –Thao-Thi, Maeng Joo- Han ; Preparation of Solid Lipid Nanoparticles and Nano structured Lipid Carriers for Drug Delivery and the Efects of Preparation Parameters of Solvent Injection Method , Molecules 2020, 25, 4781
Fireman.Sharon, Toledano.Ofer, Neimann.Karine, Loboda. Natalia & Dayan .Nava; A look at emerging delivery systems for topical drug products, Dermatologic Therapy, 2011, Vol. 24, 477–488
Katare Om Prakash. , Raza Kaisar, Singh Bhupinder, Dogra .Sunil ;Novel drug delivery systems in topical treatment of psoriasis; Rigors and vigors;Indian Journal of Dermatology, Venereology, and Leprology November-December 2010 Vol 76 Issue 6
Soni Abhishek , Jamwal Shalini . , Kumar Arvind., Thakur Shivani, Kumari Kiran; preformulation study of terbinafine for novel drug delivery system formulation ; International Journal of Research and Analytical Reviews ; September 2020, Volume 7, Issue 3
Kumar T. Praveen, Raju P. Narayana ; Transungual Drug Delivery: A Promising Route to Treat Nail Disorders ; International Journal of Pharma Research & Review, April 2013; 2(4):22-33
Kishun1 Jai, Ankur Srivastava Ankur , Vikash Chandra Vikash, Vishal Srivastava Vishal , Singh Ravindra , Navneet Kumar Verma Navneet kumar ; In-vitro evaluation of an anti-fungal nail lacquer containing miconazole nitrate ; neuroquantology ; sep 2022 ; volume 20 ;issue 11 |; 2699-2714
Kumar B. Sravan , Kumar T. Praveen , Himabindu V and Eswaraiah M. Chinna ; formulation and evaluation of bi layer nail lacquer containing antifungal drug for the treatment of onychomycosis ; World Journal of Pharmacy and Pharmaceutical Sciences; 2020; Volume 9, Issue 7, 2191-2203
Pati Nikunja Basini , Dey Biplab Kr , Das Sudip , Sahoo Subhas1; Nail Drug Delivery System: A Review; Journal of Advanced Pharmacy Education & Research ;2012 2 (3) 101-109 (2012) ISSN 2249-3379
Mali Audumbar Digambar , Bathe Ritesh and Patil Manojkumar ; An updated review on transdermal drug delivery systems; International Journal of Advances in Scientific Research ; 2015; 1(06): 244-254
Raj R. Arun, Kurian Nithin; Formulation and Evaluation of Transungual Drug Delivery of Fluconazole Using Permeation Enhancers Screened by Hydration of Nail Plate; Research & Reviews; A Journal of Pharmaceutical Science 7006 ;Volume 8, 2229-7006
Bukke Sarad Pawar Naik , Venkatesh Chandrakala , Rajanna Sowmyashree Bandenahalli , Saraswathi Tenpattinam Shanmugam , Kusuma Praveen Kumar , Goruntla Narayana , Balasuramanyam Nitin , Munishamireddy Shilpa ; Solid lipid nanocarriers for drug delivery design innovationsand characterization strategies a comprehensive review; 16 April 2024
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