Assessment of some biomarkers (angiopoietin2, kisspeptin1) In Recurrent Aborted Women and its relationship with hypothyroidism
Keywords:
angiopoietin2, kisspeptin1, hypothyroidismAbstract
This study aims to determine the relationship between hypothyroidism and kisspeptin-1 in recurrent aborted women (RAW) during the first trimester of pregnancy in Wasit Governorate, by measuring thyroid hormones T3, T4 and TSH, evaluating the level of thyroid antibodies to determine thyroid disease , and measuring the level of kisspeptin-1 and angiopoietin 2 in the serum. Blood samples were taken from pregnant women with recurrent abortion and control groups that included normal pregnant women (NPW). Thyroid hormones, Tg-Ab and kisspeptin-1 were tested by the using of ELISA. The results of the current study indicate the level of the kisspeptin-1 significantly increases P≤ 0.05 in miscareide women RAW, and its rates reached in RAW and control 352.84 ±103.55 , 129.48 ±26.19 respectively. And there are significant increase in angiopoietin 2 P≤ 0.05 20.24 ±2.60 , 13.17 ±2.09 in RAW and NPW respectively. And the thyroid function parameters show statistically significant differences, where there is a highly statistically significant decrease P≤ 0.05 in both T3 and T4 hormones, as well as thyroid-stimulating hormone TSH in RAW when compared with control group NPW. There rates were 1.509 ±1.36, 3.864 ±1.08, 1.098 ±0.18 for T3,T4,TSH respectively in RAW, While their rates reached 9.573 ±2.13 , 9.541 ±2.53, 4.090 ±0.83 respectively in control group (NPW). Also, the level of antithyroglobulin (Tg-Ab) significantly increase P≤ 0.05 in RAW comparing to control and the rates reach (144.06 ± 47.42), (82.77 ± 7.84) in RAW and NPW respectively.
Key words: Kisspeptin-1 , Hypothyroidism , Recurrent Abortion , Anti Thyroglobulin, angiopoietin 2..
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