Nanomaterials and their application in Prosthetic Dentistry: A Comprehensive Literature Review
Keywords:
Nanoparticles, nanomaterials, prosthetic dentistry, silver nanoparticle, NanoscienceAbstract
The effects of nanotechnology are profoundly found in every aspect of science and development. Particularly, the field of dentistry is being influenced by nanotechnology making use of its immense potential. It is believed that nearly in the future, the advancement in the medical realm and the introduction of scientific devices that are tiny than dust mites may be one day capable of impressive medical miracles. However, the recent upsurge in the medical field, such as microscopy has given scientists new tools to understand and take advantage of these pre-existing natural phenomena when the matter is organized at the nanoscale. These Nanoparticles can be easily manipulated for surface chemistry, bonding capability when compared with bulk material and are overpowering.
The application of nanotechnology in dental sciences leads to the emergence of Nanodentistry which involves the maintenance of good oral health while using different biotechnologies and Nanomaterials with enhanced physical properties and antimicrobial potential. A variety of nanostructures such as nanofibre, nanorobotics,etc., have been considered for various applications in dentistry. Nanomaterials were included in a variety of oral health care products in the field of preventive dentistry and have been exploited in the development of restorative material. Nanomaterials have improved the treatment protocol in all important fields of dentistry such as endodontics, periodontics, tissue regeneration, implants, maxillofacial prosthetics, and restorative dentistry.
This review article is an attempt to provide a brief introduction and historical background regarding nanotechnology, an overarching view on Nanomaterials, and its application in the field of Prosthodontics.
Downloads
Metrics
References
Kesharwani P, Gorain B, Low SY, et al. Nanotechnology-based approaches for anti-diabetic drugs delivery. Diabetes Res Clin Pract. 2018;136:52–77. DOI: 10.1016/j.diabres.2017.11.018
X. Li, R. Cui, W. Liu, L. Sun, B. Yu, Y. Fan, et al.The use of nanoscaled fibers or tubes to improve biocompatibility and bioactivity of biomedical materials J Nanomater, 2013 (2013)
Saravanan M, Barik SK, Mubarakali D, Prakash P, Pugazhendhi A. Synthesis of silver nanoparticles from Bacillus brevis (NCIM 2533) and their antibacterial activity against pathogenic bacteria. Microb Pathog. 2018;116:221–226. DOI: 10.1016/j.micpath.2018.01.038
Oves M, Aslam M, Rauf MA, et al. Antimicrobial and anticancer activities of silver nanoparticles synthesized from the root hair extract of Phoenix dactylifera. Materials Science and Engineering: C. 2018;89:429–443. DOI: 10.1016/j.msec.2018.03.035
Coutinho I F, Aras M A, D’souza K M. Nanomaterials and their applications in prosthodontics: A review. J Res Dent 2018, 6(6): 124-131. DOI: 10.19177/jrd.v6e62018124-131
Feynman R P. There’s plenty of room at the bottom.1960 Eng.Sci.23, 22-36.
http://resolver.caltech.edu/CaltechES:23.5.1960Bottom
Taniguchi, N. (1974) On the Basic Concept of Nanotechnology. Proceedings of the International Conference on Production Engineering, Tokyo, 18-23.https://www.scirp.org/reference/referencespapers?referenceid=1241841
Feynman R. “Six Easy Pieces”. Mento Park, CA: Addison Wesley Pub Co; 1963. p. 11.
ISBN 0-8053-2501-8 (paperback)
Anne G, Manne P, Kalluri L, Kadiyala K K, Anche S C, J Ravi Rakesh Dev. The changing phase of Prosthodontics: Nanotechnology. J Dent Allied Sci 2015;4:78-83. DOI: 10.4103/2277-4696.171523
Zafar MS, Alnazzawi AA, AlrahabiM,FareedMA,at al. Nanotechnology and Nanomaterials in Dentistry. Advanced Dental Biomaterials.Elsevier Ltd.2019. DOI:10.1016/B978-0-08-102476-8.00018-9
Kolosnjaj J, Szwarc H, Moussa F. Toxicity studies of carbon nanotubes. BioApplications of Nanoparticles. Springer; 2007:181–204.DOI: 10.1007/978-0-387-76713-0_14
Yin PT, Shah S, Chhowalla M, Lee K-B. Design, synthesis, and characterization of graphene–nanoparticle hybrid materials for bioapplications. Chem Rev. 2015;115:2483–2531.DOI: 10.1021/cr500537t
Li L, Pan H, Tao J, et al. Repair of enamel by using hydroxyapatite nanoparticles as the building blocks. J Mater Chem. 2008;18:4079–4084. DOI: 10.1039/B806090H
Arefian Z, Pishbin F, Negahdary M, Ajdary M. Potential toxic effects of Zirconia Oxide nanoparticles on liver and kidney factors. Biom Res. 2015;26.
Murugadoss S, Lison D, Godderis L, et al. Toxicology of silica nanoparticles: an update. Arc Toxicol. 2017;1–44.DOI: 10.1007/s00204-017-1993-y
Shi H, Magaye R, Castranova V, Zhao J. Titanium dioxide nanoparticles: a review of current toxicological data. Particle FibreToxicol. 2013;10:15.DOI: 10.1186/1743-8977-10-15
Katsumiti A, Gilliland D, Arostegui I, Cajaraville MP. Mechanisms of toxicity of ag nanoparticles in comparison to bulk and ionic ag on mussel hemocytes and gill cells. PloS One. 2015;10:e0129039.DOI: 10.1371/journal.pone.0129039
Burke FJ. Maximising the fracture resistance of dentine-bonded all-ceramic crowns. J Dent. 1999 Mar;27(3):169-73. doi: 10.1016/s0300-5712(98)00050-5. PMID: 10079622.
Sree KS, Abhishek V, Sidhartha S, Srikanth L, Ramakrishna M, Lakshmi V. Nanotechnology in prosthodontics. IP Ann ProsthodontRestor Dent 2021;7(1):22-28
DOI: 10.18231/j.aprd.2021.005
Balaji PR, Jhaveri HM. Nanotechnology: The future of dentistry. J Indian Prosthodont Soc. 2005;5(1):21–8. DOI: 10.4103/0972-4052.16335
Anusavice KJ Phillip’s Science of Dental Materials, 11th ed.; Saunders Co., Elsevier Science Ltd.: Bethesda, MD, USA, 2003.ISBN:9780721693873, 0721693873
Uno M, Kurachi M, Wakamatsu N, Doi Y. Effects of adding silver nanoparticles on the toughening of dental porcelain. 2013 J. Prosthet. Dent;109: 242–247. DOI: 10.1016/S0022-3913(13)60052-9
Persson C, Unosson E, Ajaxon I, Engstrand J et al. Nanograin sized zirconia silica glass ceramics for dental applications. J Eur Ceram Soc 2012; 32(16) :4105-10.DOI: 10.1016/j.jeurceramsoc.2012.06.028
Raj V, Mumjitha MS. Formation and surface characterization of nanostructured Al2O3- TiO2 coatings. Bulletin of mater Sci 2014;37(6) :1141-1148.doi.org/10.1007/s12034-014-0090-6
Chen C, Trinidade FZ, de Jager N, Kleverlaan CJ, FeilzerAJ.The fracture resistance of a CAD/CAM Resin Nano ceramic (RNC) and a CAD ceramic at different thickness. Dent Mater 2014; 30(9);954-962.DOI: 10.1016/j.dental.2014.05.018
Reising A, Yao C, Storey D, Webster DJ. Greater osteoblast long term functions on ionic plasma deposited nanostructure orthopaedic implant coating. J Biomed Mater A 2008;87:78-83.DOI: 10.1002/jbm.a.31772
Patil M, Mehta DS,Guvva S. Future impact of nanotechnology on medicine and dentistry. J Indian Soc Periodont 2008 May;12(2):34-40. doi: 10.4103/0972-124X.44088
Yeswante B, Baig N, Bhandhari S, Gaikwad S et al. Nanotechnology Prosthodontic Aspect. J Appl Dent Med Sci 2016;2(2) :150-156.
Yoshida K, Tanagawa M, Matsumoto S, Yamada T, Atsuta M. Antibacterial activity of resin composites with silver containing materials. Euro J Oral Sci 1999; 107(4): 290-296. DOI: 10.1046/j.0909-8836.1999.eos107409.x
Elsaka SE, Hamouda IM, Swain MV. TiO2 nanoparticles addition to conventional glass ionomer restoratives: Influence on physical and antibacterial properties. J Dent 2011;34:589-598.DOI: 10.1016/j.jdent.2011.05.006
Cibim DD, Saito MT, Giovani PA, Borges AS, Pecorari VGA et al. Novel Nanotechnology of TiO2 improves physical chemical and biological properties of Glass ionomer Cement. Int J Biomater volume 2017. DOI: 10.1155/2017/7123919
Sikka N, Brizuela M. Glass Ionomer Cement. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK582145/
Baheti MJ, Toshniwal NG. Nanotechnology : a Boon to Dentistry. J Dent Sci Oral Rehab 2014;5(2)78-88.
Ramos-Tonello CM, Lisboa-Filho PN, Arruda LB, Tokuhara CK, Oliviera RC et al. Titanium dioxide nanotubes addition to self adhesive resin cement: Effect on physical and biological properties. Dent Mater 2017. DOI: 10.1016/j.dental.2017.04.022
Karimi MA, Haghdar et al. Synthesis and Characterization of nanoparticles and nanocomposites of ZnO and MgO by sonochemical method and their application for Zinc polycarboxylate dental cement preparation. Int Nano Lett 2011;1(1):43-51.
Choi JY, Kim KH, Choy KC, Oh KT, Kim KH. Photocatalytic antibacterial effects of TiO2 film formed on Ti and Tiag exposed to lactobacillus acidophilus. J Biomed Mater Res B Appl Biomater2007;80:353-359. DOI: 10.1002/jbm.b.30604
Shekhar A, Soumyo M, Suparna M. Immobilized silver nanoparticle enhance contact killing and show highest efficacy:elucidation of the mechanism of bactericidal action of silver. Nanoscale 2013;5:7328-40. https://doi.org/10.1039/c3nr00024a
Douglas RM, Luiz FG,Aline ST, Emerson R. The growing importance of material that prevent microbial adhesion: antimicrobial effects of medical devices containing silver. Int J of Antimicrobial Agents 2009;34:103-110.DOI: 10.1016/j.ijantimicag.2009.01.017
God MM, Abualsaud R, Rahoma A, AlThobity AM et al. Effect of Zirconium oxide nanoparticles addition on the optical properties of polymethyl methacrylate denture base material. Int J nanomedicine 2018;13:283-292. DOI: 10.2147/IJN.S152571
Lessa FC, Enoki C, Ito IY, Faria G, Matsumoto MA, Nelson- Filho P. In vivo evaluation of bacterial contamination and disinfection of acrylic baseplates of removable orthodontic appliances. Am J Orthod dentofacial Orthop 2007; 131: 705:11-1. DOI: 10.1016/j.ajodo.2006.09.042
Acosta- Torres LS, Lopez- Marin LM, Nunez- Anita RE, Hernandez-Padron G, Castano VM. Biocompatible metal oxide nanoparticles: Nanotechnology improvement of conventional prosthetic acrylic resins. J Nanomater 2011. https://doi.org/10.1155/2011/941561
Gad M, ArRajaie AS, Abdel Halim MS, Rahoma A. 2016. The reinforcement effect of nano zirconia on the transverse strength of repaired acrylic denture base. Int J Dentistry 2016, 7094056.DOI: 10.1155/2016/7094056
Davidson RS, Kolb BU, Anderson DB, Higgins JA et al. Zirconia particles. US patent 7, 2007;241:437
Okita N, Orstavik D, Orstavik J, Ostby K. In vivo and in vitro studies on soft denture materials: microbial adhesion and test for antibacterial activity. Dent Mater 1991;7:155-60. DOI: 10.1016/0109-5641(91)90035-w
Ki-Young N. In vitro antimicrobial effect of the tissue conditioner containing silver nanoparticles. J Adv Prosthodont2011;3:20-24.doi: 10.4047/jap.2011.3.1.20
Garner SJ, Nobbs AH, McNally LM, Barbour ME. An antifungal coating for dental silicones composed of chlorhexidine nanoparticles. J Dent 2015;43(3):362-72.DOI: 10.1016/j.jdent.2014.12.005
Aziz T, Waters M, Jagger R. Analysis of the properties of silicone rubber maxillofacial prosthetic materials. J Dent 2003;31(1):67-74. DOI: 10.1016/s0300-5712(02)00084-2
Malathi S, Sujatha V, Mahalaxmi S. Nanotechnology- an asset to Dentistry. Int J Comm Dent 2014;5(1):27-31
Han Y, Zhao Y, Xie C, Powers JM, Kiatamnuay S. Color stability of pigmented maxillofacial silicone elastomer: effects of nano-oxides as opacifiers. J Dent 2010;38(2):100-105. DOI: 10.1016/j.jdent.2010.05.009
Yao C, Slamovich EB, Webster TJ. Enhanced osteoblast functions on anodized titanium with nanotube likestructures.J Biomed Mater Res A 2008 Apr;85(1):157-166. DOI: 10.1002/jbm.a.31551
Wei M, Ruys AJ, Swain MV, Kim SH, Milthrope BK, Sorrel CC. Interfacial bond strength of electrophoretically deposited hydroxyapatite coatings on metals. J Mater sci Mater Med 1999;10:401-9.DOI: 10.1023/a:1008923029945
Besinis A, Hadi s, Le H, Tredwin C, Handy R. Antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver titanium dioxide and hydroxyapatite nanocoatings, Nanotoxicology 2017 11:30327-38. DOI: 10.1080/17435390.2017.1299890
Briggs EP, Walpole AR, Wilshaw PR, Karlson M, Palsgard E. Formation of highly adherent nano-porous alumina on Ti based substrates: A novel bone implant coating. J Mater Sci Mater Med 2004; 15;1024-9. DOI: 10.1080/17435390.2017.1299890
Vincent MJI Cuijpers, Hamdan S Alghamdi, Natasja WM van Dijk, Jakub Jarszewicz, X frank Walboomers, John A Jansen. J Biomed Mat Res 2015;11(103):3463-73.
Lapatki BG, Bartholomeyczik J, Ruther P, Jonas IE, Paul O (2007) Smart bracket for multidimensional force and moment measurement. J Dent Res 86:73–78. DOI: 10.1177/154405910708600112
Thomas B, Mathew CA, Muthuvignesh J. Nanotechnology- Application in Prosthodontics:A Literature review. J orofReaea 2014;4(2):103-110
Mantri SS, Mantri SP. The nano era in dentistry. J Natural Sci Bio Med 2013;4(1):39-44.doi: 10.4103/0976-9668.107258
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.