Formulation and Evaluation of Novel Lipid-Based Nanocarriers for Targeted Ocular Delivery of Prednisolone Acetate

Abstract

Objective: In the present research work, the aim was to prepare and evaluate prednisolone acetate solid lipid nanoparticles at eye surface for the treatment of ocular inflammation.

Methods: Solid lipid nanoparticles were prepared by high pressure homogenization followed by probe sonication. The amounts of polymers were selected on the basis of optimum quantity required for sustained release of drugfrom preparation and as reported in literature and performed ranging study.

Results and discussion: Glyceryl monostearate, Tween 80 and transcutol P were used as solid lipid, surfactant and co-surfactant respectively. All formulation was evaluated for particle size, zeta potential, entrapment efficiency % drug content and release study. Nine formulations for each approach were prepared and optimized successfully using 3² factorial designs. Optimization was done by DoE software version Version 13.0.10.064.

Conclusion: Solid lipid nanoparticles were successfully developed using high pressure homogenization method. Results of the various parameters indicated that prednisolone acetate can be formulated into nanoparticles using GMS thereby improving its ocular permeability. Stability studies indicated no change in coloration or any other physical parameters.