Formulation, Characterisation and Pharmacological Evaluation of Silver Nanoparticles of Extract of Alstonia Scholaris
DOI:
https://doi.org/10.52783/jns.v14.3633Keywords:
Alstonia Scholaris, Antimicrobial, Antioxidant, Anti-Inflammatory, Biocompatibility, Cytotoxicity, Green Synthesis, Nanomedicine, Pharmacological Evaluation, Silver Nanoparticles, Sustainable Nanotechnology, Wound HealingAbstract
This study focuses on the formulation, characterization, and pharmacological evaluation of silver nanoparticles (AgNPs) synthesized from the extract of Alstonia scholaris, a medicinal plant known for its antimicrobial and therapeutic properties. The synthesis was achieved through a green chemistry approach utilizing environmentally friendly methods, which involved the reduction of silver ions using the phytochemicals present in the A. scholaris extract. The resultant AgNPs were characterized using various techniques such as UV-Visible spectroscopy, X-ray diffraction (XRD), and transmission electron microscopy (TEM), confirming their size, morphology, and crystalline structure. Pharmacological evaluations demonstrated significant antimicrobial activity against a spectrum of pathogenic bacteria and fungi, highlighting their potential as effective agents in combating microbial resistance. Furthermore, the cytotoxic effects of AgNPs on cancer cell lines were assessed through in vitro assays, indicating their utility in oncological applications. This research emphasizes the dual functionality of silver nanoparticles derived from A. scholaris as potent antimicrobial and anticancer agents, paving the way for future developments in nanomedicine and green synthesis methodologies. The findings support the integration of AgNPs in therapeutic applications while ensuring environmental sustainability
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Garud, M., Supraja, N., & Prasad, T. N. V. K. V. (2014). Synthesis of silver nanoparticles using Alstonia scholaris bark extract and their antimicrobial activity. Journal of Nanostructure in Chemistry, 4(1), 161–170.
Prasad, T. N. V. K. V., Supraja, N., & Garud, M. (2014). Green synthesis of silver nanoparticles using Alstonia scholaris bark extract: Characterization and antimicrobial activity. Journal of Nanostructure in Chemistry, 4(1), 161–170.
Mishra, S., Shimpi, S. L., & Shirole, S. (2015). Green synthesis of silver nanoparticles using Alstonia scholaris leaf extract and their characterization. Current Nanoscience, 7(1), 49–54.
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