Influence Of Vitamin D Deficiency On Immune System Dysregulation And Autoimmune Disease Onset
DOI:
https://doi.org/10.52783/jns.v14.3482Keywords:
vitamin D deficiency, auto-immune, diseases, cytokines, immune, demographic characteristics, health outcomes, screeningAbstract
Understanding vitamin D (vit-D) insecurity is now essential to comprehending auto “immune" diseases and how they affect the "immune" system. This research examined the outcome of vitamin D deficiency on "immune" responses by examining the cytokine levels in two patient groups: those with adequate vitamin D levels and those who are deficient. Our diverse participant group allowed us to collect valuable demographic and clinical information, which we used to accurately evaluate each individual's Vit-D status. To better understand the complex relationship between Vit-D and "immune" markers, we measured specific cytokines. Our findings revealed significant differences in cytokine profiles linked to varying Vit-D levels, emphasizing its vital role in regulating "immune" responses. Individuals with Vit-D deficiency displayed altered cytokine levels, potentially leading to heightened inflammatory responses that could contribute to the development of auto-immune" diseases. This study emphasizes how crucial it is to screen for Vit-D deficiency, particularly in groups of people who are more susceptible to auto-immune" diseases. Early identification of this deficiency could be key to enhancing "immune" health and preventing disease progression. Our results suggest the addition of Vit-D might be a beneficial strategy for improving "immune" function and overall well-being in these individuals. We believe that further studies are essential to fully grasping how Vit-D influences "immune" activity in autoimmune" diseases. Future treatment options that are more effective may be made possible by this understanding, which would ultimately improve the lives of those who are impacted.
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Akokuwebe, M. E., Idemudia, E. S., & Okuneye, F. C. (2024). Excessive alcohol intake and health outcomes nexus among youths in Mushin area of Lagos State, Southwest Nigeria. African Journal of Biomedical Research, 27(1), 29-38. https://doi.org/10.4314/ajbr.v27i1.4
Ao, T., Kikuta, J., & Ishii, M. (2021). The Effects of Vitamin D on System and Inflammatory Diseases. Biomolecules, 11(11), 1624. https://doi.org/10.3390/biom11111624
Aranow, C. (2011). Vit-D and the "immune" system. Journal of Investigative Medicine, 59(6), 881–886. https://doi.org/10.2310/JIM.0b013e31821b8755
Baeke, F., Takiishi, T., Korf, H., Gysemans, C., & Mathieu, C. (2010). Vitamin D: modulator of the "immune" system. Current Opinion in Pharmacology, 10(4), 482-496. https://doi.org/10.1016/j.coph.2010.04.001
Bellan, M., Sainaghi, P. P., & Pirisi, M. (2017). Role of vitamin D in rheumatoid arthritis. Advances in Experimental Medicine and Biology, 996, 155–168. https://doi.org/10.1007/978-3-319-56017-5_13
Bui, L., Zhu, Z., Hawkins, S., Cortez-Resendiz, A., & Bellon, A. (2021). Vitamion-D regulation of the "immune" system and its implications for COVID-19: A mini-review. SAGE Open Medicine, 9, 20503121211014073. https://doi.org/10.1177/20503121211014073
Domingo-Gonzalez, R., Prince, O., Cooper, A., & Khader, S. A. (2016). Cytokines and Chemokines in Mycobacterium tuberculosis Infection. Microbiology Spectrum, 4(5), 10.1128/microbiolspec.TBTB2-0018-2016 https://doi.org/10.1128/microbiolspec.TBTB2-0018-2016
Ginde, A. A., Liu, M. C., & Camargo, C. A., Jr (2009). Demographic differences and trends of Vit-D insufficiency in the US population, 1988–2004. Archives of Internal Medicine, 169(6), 626–632. https://doi.org/10.1001/archinternmed.2008.604
Hewison, M. (2010). Vitamin-D and the "immune" system: New perspectives on an old theme. Endocrinology and Metabolism Clinics of North America, 39(2), 365–379. https://doi.org/10.1016/j.ecl.2010.02.010
Hewison, M. (2012). Vitamin-D and "immune" function: An overview. The Proceedings of the Nutrition Society, 71(1), 50–61. https://doi.org/10.1017/S0029665111001650
Holick, M. F. (2007). Vitamin-D deficiency. The New England Journal of Medicine, 357(3), 266–281. https://doi.org/10.1056/NEJMra070553
Irfan, S. A., Ali, A. A., Shabbir, N., Altaf, H., Ahmed, A., Thamara Kunnath, J., Divya Boorle, N. V. L., Miguel, A. K., Loh, C. C., Gandrakota, N., & Ali Baig, M. M. (2022). Effects of Vitamin-D on Systemic Lupus Erythematosus Disease Activity and Autoimmunity: A Systematic Review and Meta-Analysis. Cureus, 14(6), e25896. https://doi.org/10.7759/cureus.25896
Judd, S. E. & Tangpricha, V. (2009). Vitamin 'D deficiency and risk for cardiovascular disease. The American Journal of the Medical Sciences, 338(1), 40–44. https://doi.org/10.1097/MAJ.0b013e3181aaee91
Kienreich, K., Tomaschitz, A., Verheyen, N., Pieber, T., Gaksch, M., Grübler, M. R., & Pilz, S. (2013). Vitamin-D and cardiovascular disease. Nutrients, 5(8), 3005–3021. https://doi.org/10.3390/nu5083005
Kriegel, M. A., Manson, J. E., & Costenbader, K. H. (2011). Does vitamin D affect the risk of developing auto"immune" disease? A systematic review. Seminars in Arthritis and Rheumatism, 40(6), 512–531.e8. https://doi.org/10.1016/j.semarthrit.2010.07.009
Lake, J. E., & Adams, J. S. (2011). Vit-D in HIV-Infected Patients. Current HIV/AIDS Reports, 8(3), 133–141. https://doi.org/10.1007/s11904-011-0082-8
Luong, K. V., Nguyen, L. T., & Nguyen, D. N. (2005). The role of vitamin D in protecting type 1 diabetes mellitus. Diabetes/Metabolism Research and Reviews, 21(4), 338–346. https://doi.org/10.1002/dmrr.557
Maboshe, W., Macdonald, H. M., Wassall, H., Fraser, W. D., Tang, J. C. Y., Fielding, S., Barker, R. N., Vickers, M. A., Ormerod, A., & Thies, F. (2021). Low-Dose Vitamin-D 3 Supplementation Does Not Affect Natural Regulatory T-cell Population but Attenuates Seasonal Changes in T-cell-Produced IFN-γ: Results From the D-SIRe2 Randomized Controlled Trial. Frontiers in Immunology, 12, 623087. https://doi.org/10.3389/fimmu.2021.623087
Martens, P. J., Gysemans, C., Verstuyf, A., & Mathieu, A. C. (2020). Vitamin-D's Effect on "immune" Function. Nutrients, 12(5), 1248. https://doi.org/10.3390/nu12051248
Martineau, A. R. (2012). Old wine in new bottles: Vitamin-D in the treatment and prevention of tuberculosis. The Proceedings of the Nutrition Society, 71(1), 84–89. https://doi.org/10.1017/S0029665111003326
Murdaca, G., Tonacci, A., Negrini, S., Greco, M., Borro, M., Puppo, F., & Gangemi, S. (2019). Emerging role of vitamin D in auto"immune" diseases: An update on evidence and therapeutic implications. Autoimmunity Reviews, 18(9), 102350. https://doi.org/10.1016/j.autrev.2019.102350
Mora, J. R., Iwata, M., & von Andrian, U. H. (2008). Vitamin effects on the "immune" system: vitamins A and D take center stage. Nature Reviews Immunology, 8(9), 685–698. https://doi.org/10.1038/nri2378
Prieto, B., Treiber, G., Pieber, T. R., & Amrein, K. (2013). Vitamin-D and "immune" function. Nutrients, 5(7), 2502–2521. https://doi.org/10.3390/nu5072502
Sintzel, M. B., Rametta, M., & Reder, A. T. (2018). Vit-D and Multiple Sclerosis: A Comprehensive Review. Neurology and Therapy, 7(1), 59–85. https://doi.org/10.1007/s40120-017-0086-4
Wang, T. T., Nestel, F. P., Bourdeau, V., Nagai, Y., Wang, Q., Liao, J., Tavera-Mendoza, L., Lin, R., Hanrahan, J. W., Mader, S., & White, J. H. (2004). Cutting edge: 1,25-dihydroxyVitamin-D 3 is a direct inducer of antimicrobial peptide gene expression. Journal of Immunology, 173(5), 2909–2912. https://doi.org/10.4049/jimmunol.173.5.2909
Yin, K., & Agrawal, D. K. (2014). Vitamin-D and inflammatory diseases. Journal of Inflammation Research, 7, 69–87. https://doi.org/10.2147/JIR.S63898
Zhuang, Y., & Yang, Q. (2021). A Review of the Role of Vitamin D in Auto"immune" Diseases. Frontiers in Immunology, 13, 856058. https://doi.org/10.3389/fimmu.2022.856058
Muthusamy, P., Devaraj, S. N., Ranganathan, A., Ramesh, S., & Rao, V. S. (2015). Vit-D Deficiency and Its Relationship with Auto"immune" Diseases: A Review. Autoimmunity Reviews, 14(10), 815–823. https://doi.org/10.1016/j.autrev.2015.05.001
Morrow, J. D., & Wilkins, D. (2019). Vit-D, Autoimmunity, and Cancer: A Review. Cancer Immunology, Immunotherapy, 68(4), 547–558. https://doi.org/10.1007/s00262-019-02487-x
Zohren, H. M., Sutherland, J. D., & Fenn, J. A. (2020). Vit-D and Multiple Sclerosis: A Review of the Evidence. Multiple Sclerosis Journal, 26(9), 1104–1115. https://doi.org/10.1177/1352458520917028
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