Phrmacognostical Profile and In-vitro Antidiabetic activity of ethanolic extracts of Dichanthium annulatum and Saccharum benghalense
DOI:
https://doi.org/10.52783/jns.v14.3450Keywords:
Dichanthium annulatum, Saccharum benghalense, Poaceae, Phytochemicals, Cytotoxic effectAbstract
Diabetes mellitus is a group of metabolic diseases that involve inadequate glucose utilization and excessive glucose production, which leads to hyperglycemia. Before accomplishing in vivo studies, it is crucial to thoroughly investigate the impact of the experimental drugs utilizing in vitro models. Thus, the test chemicals will likely undergo in vitro antidiabetic investigation, such as alpha amylase inhibitory action. Dichanthium annulatum and Saccharum benghalense belongs to Poaceae family. Poaceae plants have been utilized in folk medicine for a variety of ailments, including hypertension, diabetes, inflammation, anthelmintic, astringent, ulcerative, diuretic, & antioxidant effects. The assay results suggest that the existence of bioactive compounds could be responsible for the versatile medicinal properties of this plant including diabetes, the extract exhibit the IC50 values of alpha amylase inhibitory activity of ethanolic extracts of Dichanthium annulatum and Saccharum benghalense were 110 μg/mL and 189.655 μg/mL respectively, when compared with Acarbose (IC50 65.454 μg/mL). The current study proves that the antidiabetic activity of ethanolic extract of Dichanthium annulatum and Saccharum benghalense leaves by in vitro studies.
Thus, objective of the present study is to investigate the Phrmacognostical screening and in-vitro antidiabetic activity of ethanolic leaves extract of Dichanthium annulatum, Saccharum benghalense leaves.
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Rais N, Ahmad R, Ved A, Parveen K, Bari DG, Prakash O. Diabetic ketoacidosis (DKA), a leading risk factor for mucormycosis (black fungus), during the era of coronavirus disease-2019 (COVID-19): an overview. Current Diabetes Reviews. 2023 Jan 1;19(1):33-45.
Rais N, Ved A, Ahmad R, Parveen A. based Analytical Procedures to Evaluate Diabetic Biomarkers and Related Parameters: In Vitro and In Vivo Methods. Current Diabetes Reviews. 2024 Jul 1;20(6):58-73.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2010 Jan 1;33(Supplement_1):S62-9.
Rais N, Ved A, Ahmad R, Parveen K, Prakash O. Prevalence of diabetes mellitus and sociodemographic survey in the community of Western Uttar Pradesh, India in the Year 2019-2020. International Journal of Current Research and Review. 2021 Jan;13(1):10-5.
Lorian V. Differences between in vitro and in vivo studies. Antimicrobial agents and chemotherapy. 1988 Oct;32(10):1600-1..
Wan LS, Chen CP, Xiao ZQ, Wang YL, Min QX, Yue Y, Chen J. In vitro and in vivo anti-diabetic activity of Swertia kouitchensis extract. Journal of Ethnopharmacology. 2013 Jun 3;147(3):622-30.
Awad MM, Ragab EA, Atef A. Phytochemical investigation and biological evaluation of Dichanthium annulatum (Forrsk). Journal of Scientific and Innovative Research. 2015;4(3):131-7.
Singh S, Neeraj S, Deenanath J. A Critical Review On Ruellia Tuberosa, Saccharum Benghalense And Dichanthium Annulatum With Huge Availability In'Middle Ganga Segment'. Journal of Pharmaceutical Negative Results. 2023;14(1):748-54.
Gami B, Parabia MH. Pharmacognostic evaluation of bark and seeds of Mimusops elengi L. Int J Pharm Pharm Sci. 2010;2(Suppl 4):110-3.
Gaddaguti V, Ch SR, Bhogireddy NR, Venkat B, Rao VR, Rao AP. Pharmacognostic and Preliminary Phytochemical Evaluation of Ocimum basilicum L. var. pilosum (Willd.) Benth. and O. tenuiflorum var. CIM-AYU. methods. 2015;9(10):11-2.
Egharevba HO, Kunle FO. Preliminary phytochemical and proximate analysis of the leaves of Piliostigma thonningii (Schumach.) Milne-Redhead. Ethnobotanical leaflets. 2010;2010(5):2.
Evans WC. Trease and Evans' pharmacognosy. Elsevier Health Sciences; 2009 May 27.
Alara OR, Abdurahman NH, Ukaegbu CI, Kabbashi NA. Extraction and characterization of bioactive compounds in Vernonia amygdalina leaf ethanolic extract comparing Soxhlet and microwave-assisted extraction techniques. Journal of Taibah University for Science. 2019 Dec 11;13(1):414-22.
Yadav M, Chatterji S, Gupta SK, Watal G. Preliminary phytochemical screening of six medicinal plants used in traditional medicine. Int J Pharm Pharm Sci. 2014;6(5):539-42.
Shaikh JR, Patil M. Qualitative tests for preliminary phytochemical screening: An overview. International journal of chemical studies. 2020 Mar 1;8(2):603-8.
kumar Bargah R. Preliminary test of phytochemical screening of crude ethanolic and aqueous extract of Moringa pterygosperma Gaertn. Journal of Pharmacognosy and phytochemistry. 2015 May 1;4(1).
Saeed N, Khan MR, Shabbir M. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC complementary and alternative medicine. 2012 Dec;12:1-2.
Chang CC, Yang MH, Wen HM, Chern JC. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. Journal of food and drug analysis. 2002 Jul 1;10(3).
Alema NM, Periasamy G, Sibhat GG, Tekulu GH, Hiben MG. Antidiabetic activity of extracts of Terminalia
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