A Study of In-Vitro Hypoglycemic and Glucose Uptake Activity Ethanolic Extract of Syzygium Cumini Linn

Abstract

Natural goods, which come from living things, are very important in pharmacognosy, medicine, and agriculture. This study explores the anti-inflammatory actions and phytochemical characteristics of Syzygium cumini, also known as black jamun, a plant with therapeutic potential for the treatment of diabetes and related inflammatory disorders. Using Fourier Transform Infrared Spectroscopy (FTIR) and High-Performance Thin-Layer Chromatography (HPTLC) to characterize Syzygium cumini chemically and validate the presence of important bioactive components like Hydroxy Citric Acid (HCA), the research focuses on this process. An anti-inflammatory model generated by diabetes was created to assess the effectiveness of the Syzygium cumini extract levels and inflammatory markers such as TNF-alpha and IL-6. Furthermore,3T3-L1 adipocyte cells were used in in vitro glucose uptake tests. The outcomes demonstrated that, at lower concentrations, Syzygium cumini improves glucose absorption; peak effectiveness was noted at 20 µg/ml. This shows that Syzygium cumini may be useful in controlling hyperglycemia and inflammation in diabetes due to its insulin-sensitizing qualities. Higher extract concentrations, however, decreased glucose absorption, suggesting a potential cytotoxic effect. Overall, the research highlights Syzygium cumini promise as a natural medicinal agent for the treatment of diabetes. The results indicate that more investigation into the bioactive substances and modes of action of Syzygium cumini is necessary in order to potentially create novel therapies for diabetes and its sequelae.