Histomorphological And Immunohistochemical Evaluation of Spindle Cell Neoplasm of Gastrointestinal Tract At Tertiary Care Centre

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  • Rashmi Rani Bharti
  • Kalpana chandra
  • Guddi Rani Singh
  • Pankaj Kumar
  • Mamta Kumari
  • Deepak Kumar

DOI:

https://doi.org/10.52783/jns.v14.3271

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References

Sbaraglia M, Businello G, Bellan E. Mesenchymal tumours of the gastrointestinal tract. Pathologica 2021; 113: 230-251.

Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO Classification of Soft Tissue Tumors: news and perspectives. Pathologica 2021;113:70- 84.https://doi.org/10.32074/1591-951x-213.Epub 2020 Nov3.PMID;33179614

Rasool Z et al. Histopathological spectrum of spindle cell tumors of gastro-intestinal tract. International Journal of Advances in Medicine.2019; 6(5): 1442-1446.

Voltaggio L, Montgomery EA. Gastrointestinal tract spindle cell lesions- just like real estate, it is all about location. Modern Pathol. 2015;28(S1):47-66.

Miettinen M, Fletcher CDM, Kindblom LG, Tsui WMS. Mesenchymal tumors of the stomach. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumors of the digestive system. 4th. ed. Lyon: IARC; 2010. p. 74–9.

Beltran MA, Cruces KS. Primary tumors of jejunum and ileum as a cause of intestinal obstruction: a case control study. Int J Surg 2007;5:183-91

Patil DT, Rubin BP. Gastrointestinal stromal tumor: advances in diagnosis and management. Arch Pathol Lab Med. 2011;135(10):1298–310

Miettinen M, Fletcher CDM, Kindblom LG, Tsui WMS. Mesenchymal tumors of the colon and rectum. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumors of the digestive system. 4th ed. Lyon: IARC; 2010. p. 181–2.

Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1458 cases from 1992 to 2000. Am J Gastroenterol 2005; 100: 162–168

Rosai J. Gastrointestinal stromal tumour and its mimics. Int J Surg Pathol. 2010;18: S79-87.

Miettinen M, Sarlomo-Rikala M, Sobin LH. Mesenchymal tumours of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumours - A clinicopathologic and immunohistochemical study of eighty-eight cases. Mod Pathol. 2001;14(10):950-6.

Corless CL, Schroeder A, Griffith D et al. PDGFRA Mutations in Gastrointestinal Stromal Tumors: Frequency, Spectrum and In Vitro Sensitivity to Imatinib. J Clin Oncol 2005; 23: 5357–5364.

Jandial A, Bhardwaj S, Mahajan A. Clinicopathological profile of gastrointestinal stromal tumours in a tertiary care centre in Jammu region. JK Science: Journal of Medical Education & Research. 2022 Apr 10;24(2):123-7

Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577–580.

Hirota S. Differential diagnosis of gastrointestinal stromal tumor by histopathology and immunohistochemistry. Translational gastroenterology and hepatology. 2018;3:27

Siegel, R.L.; Wagle, N.S.; Cercek, A.; Smith, R.A.; Jemal, A. Colorectal cancer statistics, 2023. CA A Cancer J. Clin. 2023, 73, 233–254. [CrossRef].

Waidhauser, J.; Bornemann, A.; Trepel, M.; Märkl, B. Frequency, localization, and types of gastrointestinal stromal tumor associated neoplasia. World J. Gastroenterol. 2019, 25, 4261–4277. [CrossRef] [PubMed

Standring S. Gray's anatomy: the anatomical basis of clinical practice, 41ed. Philadelphia: Churchill Livingstone; 2015. p. 1–15843.

Miettinen MM, Lasota J, Corless CL, Rubin BP, Debiec-Rychter M, Sciot R, et al. Gastrointestinal stromal tumors. In: Fletcher DM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumors of soft tissue and bone, vol. 2013. 4th ed. Lyon: IARC; 2013. p. 164–7

Daniel Boll. CT and MRI of the Whole Body. (2016) ISBN: 9780323113281

Abbas NF, El-Sharkawy SL, Abdelaal WE. Histopathological and immunohistochemical characteristics of gastrointestinal stromal tumor. Journal of The Arab Society for Medical Research. 2023 Jan 1;18(1):1-2.

Espinosa I, Lee CH, Kim MK. A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol 2008;32:208-10

Yamaguchi U, Hasegawa T, Masuda T, et al. Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis. Virchows Arch. 2004;445(2):142–150.

Turner MS, Goldsmith JD. Best practices in diagnostic immunohistochemistry: spindle cell neoplasms of the gastrointestinal tract. Archives of pathology & laboratory medicine. 2009 Sep 1;133(9):1370-4.

Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic studies of 1765 cases with long-term follow-up. Am J Surg Pathol. 2005;29:52–68

Liang YM, Li XH, Li WM, Lu YY. Prognostic significance of PTEN, ki-67 and CD44s expression patterns in gastrointestinal stromal tumors. World J Gastroenterol. (2012) 18(14):1664–71. doi: 10.3748/wjg.v18.i14.1664

Min K-W. Small intestinal stromal tumors with skeinoid fibers. Clinicopathological, immunohistochemical, and ultrastructural investigations. Am J Surg Pathol. 1992;16:145–155.

Miettinen M, Furlong M, Sarlomo-Rikala M, Burke A, Sobin LH, Lasota J. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical and molecular genetic study of 144 cases. Am J Surg Pathol. 2001;25:1121–1133.

Miettinen M, Monihan JM, Sarlomo-Rikala M, et al. Gastrointestinal stromal tumors/smooth muscle tumors/GISTs in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999;23:1109–1118

Lev D, Kariv Y, Issakov J, Merhav H, Berger E, Merimsky O, Klausner JM, Gutman M: Gastrointestinal stromal sarcomas. Br J Surg 1999, 86:545–549.

Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Int J Surg Pathol 2002; 10: 81–89.

Miettinen M and Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 2006; 23: 70–83.

Choi AH, Bohn OL, Beddow TD, McHenry CR. Inflammatory myofibroblastic tumor of the small bowel mesentery: an unusual cause of abdominal pain and uveitis. J Gastrointest Surg 2011;15(April (4)):584

Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL. et al. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol. 2000;157:377–84.

Alabbas Z, Issa M, Omran A, Issa R. Mesenteric inflammatory myofibroblastic tumor as a rare cause of small intestinal intussusception. J Surg Case Rep 2020; 2020:1–3.

Kovach S, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R. et al. Inflammatory myofibroblastic tumors. J Surg Oncol. 2006;94:385–91.

Ordóñez NG, Localized (solitary) fibrous tumor of the pleura, Adv Anat Pathol, 2000, 7(6):327–340.

de Pinieux G, Karanian M, Le Loarer F, Le Guellec S, Chabaud S, Terrier P, Bouvier C, Batistella M, Neuville A, Robin YM, Emile JF, Moreau A, Larousserie F, Leroux A, Stock N, Lae M, Collin F, Weinbreck N, Aubert S, Mishellany F, Charon-Barra C, Croce S, Doucet L, Quintin-Rouet I, Chateau MC, Bazille C, Valo I, Chetaille B, Ortonne N, Brouchet A, Rochaix P, Demuret A, Ghnassia JP, Mescam L, Macagno N, Birtwisle-Peyrottes I, Delfour C, Angot E, Pommepuy I, Ranchere D, Chemin-Airiau C, Jean-Denis M, Fayet Y, Courrèges JB, Mesli N, Berchoud J, Toulmonde M, Italiano A, Le Cesne A, Penel N, Ducimetiere F, Gouin F, Coindre JM, Blay JY., NetSarc/RePPS/ResSos and French Sarcoma Group- Groupe d’Etude des Tumeurs Osseuses (GSF-GETO) networks. Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network. PLoS One. 2021;16(2):e0246958

WHO Classification of Tumours Editorial Board. Digestive system tumours. Lyon (France): International Agency for Research on Cancer 2019.

Shields CJ, Winter DC, Kirwan WO, Redmond HP (2001) Desmoid tumours. Eur J Surg Oncol 27: 701-706.

Gurbuz AK, Giardiello FM, Petersen GM, Krush AJ, 2وٴerhaus GJ, et al. (1994) Desmoid tumours in familial adenomatous polyposis. Gut 35: 377-381.

Doyle LA, Hornick JL. Mesenchymal Tumors of the Gastrointestinal Tract Other than GIST. Surg Pathol Clin 2013;6:425-473.

Rosai J. Gastrointestinal stromal tumor and its mimics. Int J Surg Pathol 2010; 18 Suppl: 79S87S

R. Nonose, J.S. Valenciano, C.M. Gonçalves da Silva, C.A. Fontes de Souza, C. A. Real Martinez, Ileal intussusception caused by Vanek’s tumor. A case report, Case Rep. Gastroenterol. 5 (1) (2011) 110–116, https://doi.org/10.1159/ 000326930.

H.U. Schildhaus, T. Cavlar, E. Binot, R. Büttner, E. Wardelmann, S. MerkelbachBruse, Inflammatory fibroid polyps harbour mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene, J. Pathol. 2 (2008) 176–182, https:// doi.org/10.1002/path.2393.

Levy AD, Quiles AM, Miettinen M, et al. Gastrointestinal schwannomas: CT features with clinicopathologic correlation. AJR Am J Roentgenol 2005;184:797-802. https://doi.org/10.2214/ ajr.184.3.01840797

Romeo S, Rossi S, Acosta Marín M, et al. Primary Synovial Sarcoma (SS) of the digestive system: a molecular and clinicopathological study of fifteen cases. Clin Sarcoma Res 2015;5:7. https://doi.org/10.1186/s13569-015-0021-3 .

D.M. Onis¸or, A.M. Boeriu, S.L. Mocan, J.R. Bartha, M.F. MCoros¸, E.D. Dobru, Vanek’s tumor: a rare cause of gastric outlet obstruction. Case report and literature review, Rom. J. Morphol. Embryol. 59 (2) (2018) 563–568.

Baa AK, Rastogi S, Fernandes S, Shrivastava S, Yadav R, Barwad A, Shamim SA, Dash NR. Insights into the medical management of gastrointestinal stromal tumours: lessons learnt from a dedicated gastrointestinal stromal tumour clinic in North India. ecancermedicalscience. 2023;17.

Jaypuriya A, Gupta GN, Faujdar M, Gupta S. Study of histomorphological spectrum of mesenchymal tumors of GIT at tertiary care centre. Int J Res Rev. 2022;9:7-20.

Bamanikar S, Sonkawade D, Bhandari P, Bamanikar A, Chandanwale S, Buch A. Histomorphology panorama of neoplastic gastrointestinal lesions in a tertiary care center. Medical Journal of Dr. DY Patil University. 2021 Jan 1;14(1):31-5.

Satwik N, Francis J, Mathias N. Gastrointestinal stromal tumours: a clinico-pathological study. International Surgery Journal. 2021 Apr 28;8(5):1559-65.

Gottapu KV, Srinivas M. A Prospective Study of Assessment of Gastric Tumours Highlighting Gastrointestinal Stromal Tumours (Gist)-A Study of 75 Cases

Rasool Z et al. Histopathological spectrum of spindle cell tumors of gastro-intestinal tract. International Journal of Advances in Medicine.2019; 6(5): 1442-1446.

Lee SJ, Hwang CS, Kim A, Kim K, Choi KU. Gastrointestinal tract spindle cell tumors with interstitial cells of Cajal: prevalence excluding gastrointestinal stromal tumors. Oncology Letters. 2016 Aug 1;12(2):1287-92.

Jumniensuk C, Charoenpitakchai M. Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis. World journal of surgical oncology. 2018 Dec;16:1-9.

Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Archives of pathology & laboratory medicine. 2006 Oct 1;130(10):1466-78.

Lamba M, Mukherjee G, Saini K. Clinico-pathologic pattern of gastrointestinal stromal tumors in southern India: A single-institution experience. J Clin Oncol 2007;25:20531

Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1458 cases from 1992 to 2000. Am J Gastroenterol 2005; 100: 162–168.

Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Archives of pathology & laboratory medicine. 2006 Oct 1;130(10):1466-78.

Ravikumar G, Kalegowda IY, Ananthamurthy A. Clinicopathologic spectrum of gastro intestinal stromal tumours-Experience at a tertiary care center. Indian Journal of Cancer. 2011 Oct 1;48(4):466-70.

Vij M, Agrawal V, Kumar A, Pandey R. Gastrointestinal stromal tumors: a clinicopathological and immunohistochemical study of 121 cases. Indian Journal of Gastroenterology. 2010 Nov;29:231-6.

Varsha P, Champaka G, Kumar RV, Krishnamurthy S. Pathological Spectrum of Gastrointestinal Stromal Tumors-A 1.5-year Experience at Kidwai Cancer Institute. Int J Sci Stud. 2018;6(6):38-45.

Ogun GO. Mesenchymal Tumours Of The Gastrointestinal Tract: The Importance And Use Of Immunohistochemistry In Characterizing Specific Tumour Entities. Nigerian Journal of Medicine. 2015 Apr 1;24(2):150-4.

Lakshmi VA, Chacko RT, Kurian S. Gastrointestinal stromal tumors: A 7-year experience from a tertiary care hospital. Indian journal of pathology and microbiology. 2010 Oct 1;53(4):628-33

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Published

2025-04-09

How to Cite

1.
Bharti RR, chandra K, Singh GR, Kumar P, Kumari M, Kumar D. Histomorphological And Immunohistochemical Evaluation of Spindle Cell Neoplasm of Gastrointestinal Tract At Tertiary Care Centre. J Neonatal Surg [Internet]. 2025Apr.9 [cited 2025Sep.18];14(12S):617-33. Available from: https://jneonatalsurg.com/index.php/jns/article/view/3271

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