A Comprehensive Review on Solid lipid Nanoparticles for precision targeting in chemotherapeutic delivery

Authors

  • Abhra Das
  • Pritam Dutta
  • Isani Dutta
  • Sumit Prasad Bhakat
  • Soumik Patra
  • Himalay De
  • Soubhik Bhattacharyya
  • Shirsha Majumdar
  • Soham Koley

DOI:

https://doi.org/10.52783/jns.v14.3249

Keywords:

SLNs, chemotherapeutics, optimization

Abstract

To overcome the drawbacks of traditional drug delivery methods, solid lipid nanoparticles (SLNs) have become a ground
breaking platform for the precise targeting of chemotherapeutic drugs. For hydrophobic medications, SLNs—which are made
of biocompatible solid lipids—offer a special blend of stability, regulated release, and improved bioavailability. Improved
cellular uptake and the possibility of tailored delivery by surface modifications with ligands that identify particular cancer
cell markers are made possible by their nanoscale size. SLNs are very beneficial in the treatment of cancer because of their
focused approach, which reduces systemic toxicity and increases therapeutic efficacy. The ability of SLN formulation
approaches to deliver chemotherapeutics has been further enhanced by recent developments, such as the addition of
multifunctional targeting moieties and the optimization of lipid composition. Furthermore, SLNs can be designed to offer
prolonged release profiles, which would improve patient compliance and lower the frequency of administration. The promise
of solid lipid nanoparticles as a flexible and successful precision medicine approach in oncology is highlighted in this
abstract, opening the door to safer and more efficient cancer treatments.

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Published

2025-04-08

How to Cite

1.
Das A, Dutta P, Dutta I, Bhakat SP, Patra S, De H, et al. A Comprehensive Review on Solid lipid Nanoparticles for precision targeting in chemotherapeutic delivery. J Neonatal Surg [Internet]. 2025 Apr. 8 [cited 2026 May 30];14(13S):370-81. Available from: https://jneonatalsurg.com/index.php/jns/article/view/3249

Issue

Vol. 14 No. 13S (2025): Journal of Neonatal Surgery

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Original Article

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