Unveiling Fucoidan's Anticancer Activity: Computational Docking with Cervical Cancer Proteins

Abstract

Many are interested in fucoidan because of its possible anticancer effects; it is a sulfated polysaccharide that comes from sea brown algae. Using computational molecular docking against important proteins related with cervical cancer, this study investigates fucoidan's anticancer efficacy. To evaluate fucoidan's stability, interaction patterns, and binding affinity to specific oncogenic targets in cervical cancer progression, molecular docking simulations were used. Fucoidan showed promise as a possible inhibitor of key pathways involved in the survival and proliferation of cancer cells, according to the results, which demonstrated significant binding interactions. Insights into the molecular mechanisms of fucoidan's anticancer action are provided by these findings, which further encourage its exploration as a potential therapeutic candidate for the treatment of cervical cancer. Fucoidan, a seaweed-derived sulphated polysaccharide, is a potential therapy for cervical cancer, a pressing global health concern, particularly affecting Asian women. Plant-derived compounds gain attention for their lower side effects in cancer treatment. Fucoidan's anticancer properties, inducing tumour cell apoptosis and inhibiting angiogenesis, have been extensively investigated. However, its efficacy against cervical cancer remains underexplored. We employ the computational docking method to assess Fucoidan's binding interactions with essential cervical cancer proteins, revealing promising binding energies, notably with tumour necrosis factor receptor-associated protein 2 and caspase-3. Fucoidan adheres to Lipinski's rule of five, suggesting oral bioavailability and drug-likeness. Molecular docking identifies specific amino acid interactions and hydrogen bonding patterns, elucidating its anticancer mechanisms. These findings set the stage for further exploration of Fucoidan as a cervical cancer therapeutic. Leveraging in silico methods offers insights into its molecular mechanisms, necessitating subsequent in vivo and in vitro validation to clarify its clinical utility.