Nanogel-Based Polyherbal Approach for Hyperpigmentation: Harnessing the Therapeutic Potential of Azadirachta Indica, Allium Cepa, and Curcuma Longa

Abstract

Nanogels are a type of nanostructured polymeric material that can be used for delivering therapeutic agents, especially in areas like drug delivery, cosmetics, and dermatology. Hyperpigmentation is a condition where certain areas of the skin become darker than the surrounding skin due to an excess production of melanin, the pigment responsible for skin color.  Nanogels can protect curcumin from oxidation and ensure its prolonged release to maximize its skin-brightening benefits. The aim of the current work is to formulate polyherbal nanogel utilizing herbal ingredients (A.indica, Curcuma longa and allium cepa) can be encapsulated within the gel's network, ensuring that the active compounds are delivered directly to the site of pigmentation with the help of Central Composite design and evaluated for particle size, entrapment efficiency, surface morphology and in-vitro drug release. Thirteen formulations were prepared using design expert software with two independent variables i.e., concentration of Pluronic F127 and concentration of polyethyleneimine at two different levels. Based on the desirability function, optimized batch was further characterized for particle size, surface morphology and in-vitro studies. The results of optimized formulation with reference to particle size, entrapment efficiency and in-vitro study were 114.7nm, 82.41% and 94.588±0.008%. The purpose of the research work was to provide controlled release of the compounds from nanogels will allow for prolonged therapeutic effects, ensuring that the ingredients penetrate the skin effectively and work continuously over time. Future research should focus on optimizing the formulation, evaluating its clinical efficacy through in vivo studies, and assessing its long-term safety and effectiveness.