The role of gut microbiome in personalized medicine and chronic disease prevention
DOI:
https://doi.org/10.52783/jns.v14.1550Keywords:
Gut microbiome, personalized medicine, chronic disease prevention, probiotics, microbiota modulation, inflammatory disorders, microbial diversity, precision healthcare.Abstract
The gut microbiome, a diverse community of microorganisms residing in the human gastrointestinal tract, plays a pivotal role in maintaining health and preventing diseases. Emerging research highlights the significant influence of the gut microbiota on chronic conditions such as diabetes, cardiovascular diseases, and inflammatory disorders. Personalized medicine has increasingly focused on microbiome modulation through diet, probiotics, and prebiotics to tailor treatments specific to an individual's microbiome composition. This approach has demonstrated promising results in mitigating disease progression and improving therapeutic outcomes. This paper reviews the gut microbiome's role in personalized medicine, with an emphasis on its application in chronic disease prevention and treatment strategies. Key challenges and future opportunities for microbiome-based interventions are also discussed, underscoring its transformative potential in healthcare.
Downloads
Metrics
References
Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M. A core gut microbiome in obese and lean twins. nature. 2009 Jan 22;457(7228):480-4. https://doi.org/10.1038/nature07540
Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, Shen D, Peng Y. A metagenome-wide association study of gut microbiota in type 2 diabetes. nature. 2012 Oct 4;490(7418):55-60. https://doi.org/10.1038/nature11450
Zhu Q, Jin Z, Wu W, Gao R, Guo B, Gao Z, Yang Y, Qin H. Analysis of the intestinal lumen microbiota in an animal model of colorectal cancer. PloS one. 2014 Mar 6;9(3):e90849. https://doi.org/10.1371/journal.pone.0123776
Sonnenburg ED, Sonnenburg JL. The ancestral and industrialized gut microbiota and implications for human health. Nature Reviews Microbiology. 2019 Jun;17(6):383-90. https://doi.org/10.1038/s41579-019-0191-8
David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014 Jan 23;505(7484):559-63. https://doi.org/10.1038/nature12820
De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences. 2010 Aug 17;107(33):14691-6. https://doi.org/10.1073/pnas.1005963107
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature reviews Gastroenterology & hepatology. 2014. https://doi.org/10.1038/nrgastro.2014.66
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature medicine. 2013 May;19(5):576-85. https://doi.org/10.1038/nm.3145
Kelly CR, Ihunnah C, Fischer M, Khoruts A, Surawicz C, Afzali A, Aroniadis O, Barto A, Borody T, Giovanelli A, Gordon S. Fecal Microbiota Transplant for Treatment ofClostridium difficileInfection in Immunocompromised Patients. Official journal of the American College of Gastroenterology| ACG. 2014 Jul 1;109(7):1065-71. https://doi.org/10.1038/ajg.2014.121
Franzosa EA, Morgan XC, Segata N, Waldron L, Reyes J, Earl AM, Giannoukos G, Boylan MR, Ciulla D, Gevers D, Izard J. Relating the metatranscriptome and metagenome of the human gut. Proceedings of the National Academy of Sciences. 2014 Jun 3;111(22):E2329-38. https://doi.org/10.1073/pnas.1319284111
Nayak A, Raghatate KS. Image segmentation and classification of aquatic plants using convolutional neural network. International Journal of Aquatic Research and Environmental Studies. 2024;4(S1):14-19. https://doi.org/10.70102/IJARES/V4S1/3
Uvarajan KP. Integration of blockchain technology with wireless sensor networks for enhanced IoT security. Journal of Wireless Sensor Networks and IoT. 2024;1(1):15-18.
Arshath M. Detection of soft errors in clock synthesizers and latency reduction through voltage scaling mechanism. Journal of VLSI Circuits and Systems. 2024;6(1):43-50.
Kohsari H. The effect of dietary lipids on reproductive performance in rainbow trout (Oncorhynchus mykiss). International Journal of Aquatic Research and Environmental Studies. 2023;3(1):69-74. https://doi.org/10.70102/IJARES/V3I1/7
Jeon S, Lee H, Kim HS, Kim Y. Universal shift register: QCA based novel technique for memory storage modules. Journal of VLSI Circuits and Systems. 2023;5(2):15-21.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.