Pharmacokinetics and pharmacodynamics of medications used in children: a systematic review
Keywords:
Pediatric formulation, pediatric investigation, medication adherenceAbstract
Which methylated xanthine is safe and effective for treating apnea of prematurity in underdeveloped nations is still up for debate. The majority of newborns in developing nations are small for gestational age. For both Appropriate for Gestational Age and Small for Gestational Age infants, many doctors use the same dosage of methylxanthines. In order to optimize the dosages of caffeine and aminophylline in preterm infants with apnea, population PKPD models for these drugs must be developed and qualified. The study also aimed to examine the safety and effectiveness of routine prescribed doses of aminophylline and caffeine for apnea of prematurity. Caffeine at the usual suggested dosages for treating preterm apnea can be maintained. Since postnatal age had a major impact on Vd, it was clear that time-related developmental factors had a considerable impact on the pharmacokinetics of aminophylline. Doses determined using mg/kg would be biased. The current study's calculated dose of aminophylline can be used as a substitute for the commonly advised dosage. Comparative evaluation indicates that caffeine and aminophylline are similarly efficient at lowering apnea. There were noticeably fewer tachycardia episodes when caffeine was consumed.
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