Assessing Pediatric Drugs' Safety and Effectiveness: A Systematic Review and Meta-Analysis
Keywords:
Safety, efficacy, medical errors, pediatric medicationsAbstract
The public health issue of patient safety and effectiveness is becoming more widely acknowledged. Most medications do not come in dosage forms that are appropriate for giving to children. Most therapies used to prevent or treat illnesses in infants and children are medications that were created and researched for use in adults. They might not work the best and/or are administered in unappetizing dosage forms, which eventually results in low patient adherence and insufficient medication exposure. Among the most frequent medical mistakes are those involving medications, and research indicates that children are especially susceptible. Any stage of the drug procedure is susceptible to errors. Medication errors pose significant risks to pediatric patients, leading to adverse drug events, hospitalizations, and even fatalities. The outpatient pharmacy plays a crucial role in ensuring accurate dispensing and administration of medications. However, despite existing safety measures, medication errors continue to occur. The comprehensive review of the safety and effectiveness of pediatric drugs is the goal of this paper. In order to offer evidence-based guidance for clinical practice, this systematic review and meta-analysis attempts to assess the safety and effectiveness of frequently prescribed pediatric drugs.
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Bryant S, Singer J. Management of toxic exposure in children. Emergency Medicine Clinics. 2003 Feb 1;21(1):101-19. https://doi.org/10.1016/S0733-8627(02)00083-4
Barsagade M. Investigating the Impact of Aquatic Pollution on Human Health and Wellbeing. Aquatic Ecosystems and Environmental Frontiers. 2024 Dec 27;2(4):1-6.
Benavides S, Huynh D, Morgan J, Briars L. Approach to the pediatric prescription in a community pharmacy. The Journal of Pediatric Pharmacology and Therapeutics. 2011 Oct 1;16(4):298-307. https://doi.org/10.5863/1551-6776-16.4.298
Ibragimov S. Mavlyanova R, Burieva N, Abdusatorov S, Mengliboev A, Nazirov B, Norbotaev I, Zokirov K. Investigating the Effects of Aquatic Pollutants on Human Health. International Journal of Aquatic Research and Environmental Studies. 2024;4(1):107-112. https://doi.org/10.70102/IJARES/V4S1/18
Kalita P, Barman M, Chetia A, Goyary P, Kumari K. Mapping the landscape of literature on use of AI in libraries: A bibliometric analysis using Scopus database. Indian Journal of Information Sources and Services. 2024;14(2):24-27. https://doi.org/10.51983/ijiss-2024.14.2.04
Prabhudeva T, Hariharan R. A systematic review and meta-analysis of tuberculosis patients: Perspectives of pharmacists towards sustainability. Clinical Journal for Medicine, Health and Pharmacy. 2024;2(4):1-10.
Sterling V. Minimizing medication errors in pediatric patients. US Pharmacist. 2018;44(4):20-23.
Mustika S, Sofia ERA, Sari NAK, Poetri LN, Yudhanto HS, Handayani D. The effects of traditional Asian diet on metabolism, gut microbiota, and liver tissue in NASH rats. Natural and Engineering Sciences. 2024;9(2):309-325. https://doi.org/10.28978/nesciences.1574444
Tran H, Ngoc D. The influence of effective management on hybrid work styles and employee wellness in healthcare organizations. Global Perspectives in Management. 2024;2(4):8-14.
Cunningham KJ. Analysis of clinical interventions and the impact of pediatric pharmacists on medication error prevention in a teaching hospital. The Journal of Pediatric Pharmacology and Therapeutics. 2012;17(4):365-373.
Mathboob YM, Rahaim LAA, Ali AH. Healthcare monitoring-based Internet of Things (IoT). Journal of Internet Services and Information Security. 2024;14(4):347-359. https://doi.org/10.58346/JISIS.2024.I4.021
Ivanovska V, Rademaker CMA, van Dijk L, Mantel-Teeuwisse AK. Pediatric drug formulations: A review of challenges and progress. Pediatrics. 2014;134(2):361-372.
Khyade VB, Wanve HV. Statistics as efficient tool of analysis in biomedical research. International Academic Journal of Science and Engineering. 2018;5(1):73-84. https://doi.org/10.9756/IAJSE/V5I1/1810007
Drovandi A, Robertson K, Tucker M, Robinson N, Perks S, Kairuz T. A systematic review of clinical pharmacist interventions in paediatric hospital patients. European Journal of Pediatrics. 2018;177:1139-1148.
Clementine G, Willy S, Thomas P, Kaitai L, Duncan SW. Empowering personal health records with cloud computing. Journal of Wireless Mobile Networks, Ubiquitous Computing, and Dependable Applications. 2014;5(4):3-28.
Hermanspann T, van der Linden E, Schoberer M, Fitzner C, Orlikowsky T, Marx G, Eisert A. Evaluation to improve the quality of medication preparation and administration in pediatric and adult intensive care units. Drug, Healthcare and Patient Safety. 2019;11-18.
Nezhad RK, Ghodousi H. Optimum dams reservoir operation considering hydropower demands using dynamic programming and compared by meta heuristic methods (case study Dez Dam). International Academic Journal of Science and Engineering. 2016;3(2):43-54.
Abu Farha R, Abu Hammour K, Al-Jamei S, AlQudah R, Zawiah M. The prevalence and clinical seriousness of medication discrepancies identified upon hospital admission of pediatric patients. BMC Health Services Research. 2018;18:1-7.
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