Histopathological Classification and Clinic pathological Study of Invasive Breast Carcinoma and Its Subtypes

Pranjal S Shah; S. V. Jagtap; Nanda J Patil; S.R.Kanetkar; Harsh Machhi

doi:10.47338/jns.v14.1426

Authors

Pranjal S Shah Department of Pathology, , Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth “Deemed to be University”, Taluka-Karad, Dist-Satara, Pin-415 539, Maharashtra, India
S. V. Jagtap Professor of department of pathology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth “Deemed to be University”, Taluka-Karad, Dist-Satara, Pin-415 539, Maharashtra, India
Nanda J Patil Professor, Head of Department of Pathology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth “Deemed to be University”, Taluka-Karad, Dist-Satara, Pin-415 539, Maharashtra, India
S.R.Kanetkar Professor and Head of Department of Pathology, Head of Department of Pathology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth “Deemed to be University”,Taluka-Karad, Dist-Satara, Pin-415 539, Maharashtra, India
Harsh Machhi Department of Pathology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth “Deemed to be University”,Taluka-Karad, Dist-Satara, Pin-415 539, Maharashtra, India

DOI:

https://doi.org/10.47338/jns.v14.1426

Keywords:

Invasive Breast Carcinoma, Histopathological Classification, Subtypes, Neuroendocrine Differentiation, Immunohistochemistry, Prognosis

Abstract

Still, more women than any other disease get breast cancer around the world. When used in a clinic, it has a lot of different effects. Invasive Breast Carcinoma (IBC) is a group of tumours that come in different shapes and sizes, which affects how they are treated and how likely they are to come back. The main goal of this work is to give a full tissue description and clinicopathological study of the disease with the goal of finding and describing IBC's subtypes. Breast samples from people who had been physically removed and were labelled with IBC were looked at again. We carefully looked at 100 cases using Haematoxylin and Eosin (H&E) staining and immunohistochemistry (IHC) to check for the oestrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2). Markers such as synaptophysin A and chromogranin A were also used to check for neuroendocrine differentiation. The type of cancer that happened most often was invasive ductal carcinoma (IDC), and the type that happened second most often was invasive lobular carcinoma (ILC). Ten percent of the patients had IBCs that were mixed with neuroendocrine development. Each cancer had a different histology grade, but a lot of them were graded as II, which means they were pretty different. Fifteen percent of the samples had high amounts of HER2, and sixty percent had positive ER and PR. cancers that are developing neuroendocrine systems have a slower mitotic rate and more hormone receptor hits than cancers that are not developing neuroendocrine systems. This paper stresses how important it is to do a full tissue study and genetic description, even when dividing IBC groups.

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