Fabrication of Diabetic wound healing patch using bioactive silicate / GO composite.
Keywords:
Bioactive silicate; Graphene oxide; Wound healing patch; Tissue regeneration; Antibacterial activity..Abstract
Background: Effective wound dressings should promote tissue regeneration while preventing infection. This study aimed to fabricate and evaluate a bioactive silicate/graphene oxide (SI-GO) composite wound healing patch.
Materials and Methods: The SI-GO composite was prepared by combining bioactive silicate and graphene oxide, followed by stirring, sonication, freezing, and freeze-drying to obtain a porous scaffold. The patch was evaluated for cytocompatibility, antibacterial activity, and surface morphology using cell viability assay, agar diffusion method, and scanning electron microscopy (SEM).
Results: The SI-GO composite showed good cytocompatibility (80–85% cell viability), effective antibacterial activity, and favorable cell attachment. SEM revealed a highly porous, interconnected structure suitable for cell adhesion, nutrient transport, and wound healing. Graphene oxide improved the scaffold’s structural integrity and bioactivity.
Conclusion: The SI-GO composite demonstrated promising biocompatibility, antibacterial properties, and porous architecture, indicating its potential as an advanced wound healing biomaterial. Further in vivo studies are recommended..
AIM: Aim of the study is fabrication of wound healing patch using bioactive silicate/GO composite
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