Microbiological profile and antibiotic sensitivity in patients with urolithiasis complicated by diabetes mellitus..

Authors

  • Omarova Zahraula Habirahmanovna
  • Gadzhiev Dzhabrail Dzhamalovich
  • Gamzatova Saida Zairkhanovna
  • Aliev Batyr Shamilovich
  • Ibragimova Uza Eldarovna
  • Koichueva Asil Rasulovna
  • Koichuev Tabiin Rashidovich
  • Mirzakhanov Said Madridovich

Keywords:

urolithiasis; type 2 diabetes mellitus; urinary tract infections; microbiological profile; antibiotic sensitivity; antibiotic resistance; uropathogens; Escherichia coli; Klebsiella pneumoniae

Abstract

The combination of urolithiasis and diabetes mellitus is accompanied by an increased risk of urinary tract infections, changes in the microbiological spectrum of pathogens and an increase in antibiotic resistance. Studying the characteristics of antibiotic sensitivity in this category of patients is important for optimizing empirical antibacterial therapy.

To study the microbiological profile of urinary tract infections and determine their sensitivity to antibacterial drugs in patients with urolithiasis complicated by diabetes mellitus. A retrospective study of 120 patients with urolithiasis was conducted, of which 60 patients had concomitant type 2 diabetes mellitus, and 60 formed a comparison group. All patients underwent bacteriological examination of urine with identification of pathogens and determination of sensitivity to antibacterial drugs in accordance with the recommendations of EUCAST. Statistical data processing was performed using the IBM SPSS Statistics 27.0 program. Differences at p < 0.05 were considered statistically significant.

The most frequently isolated pathogen was Escherichia coli (41.4% and 52.8%, respectively), however, Klebsiella pneumoniae, Pseudomonas aeruginosa and multidrug-resistant microorganisms were significantly more often detected in patients with diabetes mellitus. The greatest sensitivity of microorganisms was noted to carbapenems (96.6%), fosfomycin (93.1%), amikacin (91.4%) and nitrofurantoin (89.7%). The highest resistance was registered to ampicillin (72.4%), ciprofloxacin (43.1%) and co-trimoxazole (46.6%). In patients with diabetes mellitus, strains producing extended-spectrum beta-lactamases were more often detected, and longer hospitalization was noted. Diabetes mellitus has a significant impact on the microbiological profile of urinary tract infections in patients with urolithiasis and is associated with an increased prevalence of antibiotic-resistant microorganisms. The results obtained confirm the need for a bacteriological study to determine antibiotic sensitivity before prescribing antibacterial therapy and can be used to improve regional algorithms for the treatment of urinary tract infections

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References

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Published

2026-07-21

How to Cite

1.
Habirahmanovna OZ, Dzhamalovich GD, Zairkhanovna GS, Shamilovich AB, Eldarovna IU, Rasulovna KA, et al. Microbiological profile and antibiotic sensitivity in patients with urolithiasis complicated by diabetes mellitus. J Neonatal Surg [Internet]. 2026 Jul. 21 [cited 2026 Jul. 22];15(1s):305-10. Available from: https://jneonatalsurg.com/index.php/jns/article/view/10477

Issue

Vol. 15 No. 1s (2026): Journal of Neonatal Surgery

Section

Original Article

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