Role Of Endogenous Glutathione As Regulator Of Wnt/Beta Catenin Signalling Relevant To Breast Cancer - A Molecular Docking Study

Authors

  • Prithiksha N
  • Lavanya Prathap
  • Selvaraj Jayaraman

Keywords:

Beta-catenin, MYC, Breast cancer, Exercise, Glutathione, Innovative method

Abstract

Background:Breast cancer is the most common cancer in women and the leading cause of cancer death in women after lung cancer. The risk of breast cancer increases with age. Breast cancer is a major health problem in developed countries. Glutathione is a natural antioxidant secreted endogenously post exercise that helps in maintaining the quality of life and may prevent breast cancer.

Aim: To analyse the role of endogenous glutathione as regulator of Wnt/beta catenin signaling in breast cancer through molecular docking study.

Materials and Methods: The molecular docking analysis is a bioinformatic study conducted in a private dental college. The endogenous substance Glutathione which is secreted after exercise is used as a target protein. The interaction of glutathione with proteins relevant to breast cancer namely  Beta catenin , MYC are included for docking analysis. The protein structure is retrieved using protein data bank, Protein protein docking done using patch dock server followed by visualisation of protein- protein interaction using pymol.

Results: The surface representation of Glutathione with Beta-catenin,MYC complex showed good shape complementarity. The scores representing predicted binding free energy for the top-ranked solutions, number of structurally aligned residues appearing within the distance cut-off of 4Å, and the number of hot-spot residues in the protein–protein interface were analyzed

Conclusion: From the results of the analysis and within the  limitations of the study  it can be concluded that the role of exercise induced endogenous glutathione may act as the regulator of wnt/beta catenin signaling in breast carcinoma. The exercise may help in maintaining the equilibrium of the gene expression by modulating Wnt/beta catenin signalling pathway and act as a protective factor in preventing, controlling the metastasis and aid as an adjunct therapy for breast carcinoma with good prognostic value.



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Published

2023-01-25

How to Cite

1.
N P, Prathap L, Jayaraman S. Role Of Endogenous Glutathione As Regulator Of Wnt/Beta Catenin Signalling Relevant To Breast Cancer - A Molecular Docking Study. J Neonatal Surg [Internet]. 2023 Jan. 25 [cited 2026 Jun. 30];12(1):90-6. Available from: https://jneonatalsurg.com/index.php/jns/article/view/10356

Issue

Vol. 12 (2023): Journal of Neonatal Surgery

Section

Original Article

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