Microbiological Aspects of Antibiotic Resistance in Patients with Urolithiasis and Combined Injuries.

Authors

  • Ramazanova Patimat Magomednabievna
  • Tagirov Tadjutdin Ruslanovich
  • Bagaudinov Ali Khabibovich
  • Nurova Aminat Abdulkhalikovna
  • Gadzhiev Hasan-Huseyn Aslanovich
  • Israpilova Amina Nurullakhovna
  • Serderova Milana Askerovna
  • Mazaev Kurban Mukailovich
  • Iminova Naida Kadievna
  • Abdulkhalikov Magomedsaid Magomedovich

Keywords:

urolithiasis, antibiotic resistance, urinary tract infections, combined trauma, polyresistant microorganisms, biofilms, urosepsis.

Abstract

The aim of the study was to study the microbiological features and the level of antibiotic resistance in patients with urolithiasis on the background of combined traumatic injuries.

Materials and methods. A clinical and microbiological study of 126 patients with urolithiasis was conducted, of which 78 patients had combined injuries. Clinical, laboratory, instrumental and microbiological studies were performed. The identification of microorganisms was carried out by bacteriological and molecular genetic methods with determination of sensitivity to antibacterial drugs and assessment of the ability to biofilm formation.

Results. Severe infectious and inflammatory complications of the urinary tract prevailed in patients with combined injuries. The structure of pathogens was dominated by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa. A high level of antibiotic resistance to third-generation cephalosporins and fluoroquinolones was revealed. A significant prevalence of extended-spectrum beta-lactamases and carbapenem-resistant strains has been established. More than 68% of clinical isolates had a pronounced ability to biofilm formation. Patients in the main group were significantly more likely to develop urosepsis, septic shock, and other severe complications.

Conclusion. The combination of urolithiasis and severe trauma is accompanied by a high prevalence of polyresistant hospital microflora and a severe course of infectious complications. The results obtained confirm the need for continuous microbiological monitoring, rational antibacterial therapy and the introduction of antimicrobial control programs..

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Published

2026-05-30

How to Cite

1.
Magomednabievna RP, Ruslanovich TT, Ali Khabibovich B, Abdulkhalikovna NA, Aslanovich GH-H, Nurullakhovna IA, et al. Microbiological Aspects of Antibiotic Resistance in Patients with Urolithiasis and Combined Injuries. J Neonatal Surg [Internet]. 2026 May 30 [cited 2026 Jun. 10];15(1s):131-4. Available from: https://jneonatalsurg.com/index.php/jns/article/view/10343

Issue

Vol. 15 No. 1s (2026): Journal of Neonatal Surgery

Section

Original Article

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