Impact of Preimplantation Genetic Testing for Aneuploidy (PGT-A) on IVF Pregnancy Outcomes: A Retrospective Cohort Study from a High-Altitude Fertility Center in Ecuador (2,850 m)

Authors

  • Renato David Yánez Hidalgo
  • Verónica Alejandra Jaya Baldeón
  • Dorys Elizabeth Ortiz Flores
  • Jose Augusto Duran Chavez
  • Héctor Rodrigo Remache Cevallos
  • Pablo Andrés Yánez Marcayata

Keywords:

In vitro fertilization, embryo biopsy, aneuploidy, embryo implantation, preimplantation genetic testing

Abstract

One of the primary therapy methods for infertility is in vitro fertilisation (IVF); nevertheless, the success rates are not constant. Embryo biopsy-based preimplantation genetic testing (PGT-A) has been suggested as a method to enhance the implantation and euploid embryo selection results. The objective was to conduct a retrospective study of the role of embryo biopsy as a PGT-A predictor before embryo transfer on the chances of pregnancy in IVF procedures. The study was a cross-sectional, retrospective and analytical study on 93 patients undergoing IVF comparing others with and without embryo biopsy and clinical and biological variables, including age, duration and cause of infertility, endometrial thickness, embryo quality and attempts. The statistical analysis involved Chi-square tests and odds ratio (OR) with p = 0.05.  Embryo biopsy revealed a moderate protective effect against implantation failure (OR = 0.79; 95 per cent CI 0.52–0.93), but not statistically significant (p = 0.212). Endometrial thickness less than 7 mm (OR = 29.04) and poor embryo quality (OR = 22.59) were found to be the major risk factors. On the other hand, defence mechanisms were endometrial thickness of 7 mm, good quality of embryos and embryo biopsy. PGT-A with embryo biopsy seems to be an effective and safe procedure when used selectively, especially in those patients with increased reproductive risk. This is dependent on endometrial receptivity, embryo quality and maternal age..

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Published

2026-04-25

How to Cite

1.
Yánez Hidalgo RD, Jaya Baldeón VA, Ortiz Flores DE, Duran Chavez JA, Remache Cevallos HR, Yánez Marcayata PA. Impact of Preimplantation Genetic Testing for Aneuploidy (PGT-A) on IVF Pregnancy Outcomes: A Retrospective Cohort Study from a High-Altitude Fertility Center in Ecuador (2,850 m). J Neonatal Surg [Internet]. 2026 Apr. 25 [cited 2026 Apr. 27];15(1s):56-75. Available from: https://jneonatalsurg.com/index.php/jns/article/view/10234

Issue

Vol. 15 No. 1s (2026): Journal of Neonatal Surgery

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Original Article

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