“A Comparative Clinical Study To Evaluate The Efficacy Of Darvyadi Churna Lepa And Khadiradi Vati In The Management Of Mukhapaka In Children”

Authors

  • Sibani Misra
  • Neeraj Agrawal
  • Lowkesh Chandravanshi
  • Satyawati Rathia
  • Khuleshwar Prasad
  • Pragya Thakur

Keywords:

Mukhapaka, Stomatitis, Khadiradi Vati, Darvyadi Churna Lepa

Abstract


In Ayurveda, Mukhapaka is described as an inflammatory condition of the oral cavity and is often compared with stomatitis in modern medicine. It is mainly considered a Pitta-predominant disorder involving of Rakta Dhatu, which results in symptoms such as burning sensation, pain, ulcer formation, itching, and irritation of the buccal mucosa. This condition is commonly seen in children and can significantly affect their food intake, speech, and overall well-being. Therefore, the present study was undertaken to evaluate and compare the clinical efficacy of Darvyadi Churna Lepa and Khadiradi Vati in the management of Mukhapaka in children.An open-label, randomised, double-arm clinical study was conducted on 40 pediatric patients aged 3–12 years who were clinically diagnosed with Mukhapaka. The patients were randomly divided into two equal groups of 20 each. Group A was treated with Darvyadi Churna Lepa for local application, while Group B was treated with Khadiradi Vati. The improvement was assessed based on clinical parameters such as pain, burning sensation, itching, and the number of eruptions before and after treatment.The results showed that both groups experienced statistically significant improvements in Mukhapaka symptoms. In Group A, burning sensation showed a highly significant improvement, with a maximum relief of 90%, while pain, itching, and the number of eruptions also improved significantly. In Group B, burning sensation and itching showed highly significant improvement, with maximum relief observed in itching (87.50%). However, inter-group comparison showed no statistically significant difference, indicating that both treatments were equally effective in the management of Mukhapaka in children

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References

1. Sushruta. Sushruta Samhita with Ayurveda Tattva Sandipika commentary. Shastri AD, editor. Mehta PM, foreword. Varanasi: Chaukhamba Sanskrit Sansthan; 2012. Nidanasthana;16/66. p. 391.

2. Charaka. Charaka Samhita (Purvardha). Shastri K, Chaturvedi G, editors. Varanasi: Chaukhamba Sanskrit Sansthan; 2017. Sutrasthana;20/14. p. 403.

3. Sushruta. Sushruta Samhita with Ayurveda Tattva Sandipika commentary. Shastri AD, editor. Mehta PM, foreword. Varanasi: Chaukhamba Sanskrit Sansthan; 2012. Nidanasthana;16/67. p. 392.

4. Shulman JD. Prevalence of oral mucosal lesions in children and youth in the USA. Int J Paediatr Dent. 2005;15(2):89–97. doi:10.1111/j.1365-263X.2005.00632.x

5. Govind Das Sen K. Bhaisajya Ratnavali with Siddhiprada Hindi commentary. Mishra SN, editor. Varanasi: Chaukhamba Surbharati Prakashan; 2012. Balarogadhikara;71/84. p. 1085.

6. Govind Das Sen K. Bhaisajya Ratnavali with Siddhiprada Hindi commentary. Mishra SN, editor. Varanasi: Chaukhamba Surbharati Prakashan; 2012. Mukharogadhikara;61/96–97.

7. Sushruta. Sushruta Samhita with Nibandha Sangraha commentary of Dalhan Acharya. Trikamji Y, foreword. Varanasi: Chaukhamba Sanskrit Sansthan; 2009. Nidanasthana;16/67–68. p. 392.

8. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Haritakyadi Varga. p. 201–202.

9. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Haritakyadi Varga. p. 145–146.

10. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Haritakyadi Varga. p. 7.

11. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Pushpa Varga. p. 478.

12. Govind Das Sen K. Bhaisajya Ratnavali with Siddhiprada Hindi commentary. Mishra SN, editor. Varanasi: Chaukhamba Surbharati Prakashan; 2012. Balarogadhikara;71/84. p. 1085.

13. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Vatadi Varga. p. 413.

14. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Karpuradi Varga. p. 56–57.

15. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Karpuradi Varga. p. 167.

16. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Karpuradi Varga. p. 248.

17. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Amradi Varga. p. 550.

18. Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, commentator. Pandey GD, editor. Varanasi: Chaukhamba Sanskrit Sansthan; Karpuradi Varga. p. 54–55.

19. Pasrija A, Singh R, Katiyar CK. Validated HPLC UV method for the determination of berberine in raw herb Daruharidra (Berberis aristata DC), its extract, and in commercially marketed Ayurvedic dosage forms. Int J Ayurveda Res. 2010;1(4):243–246.

20. Wahab S, Annadurai S, Abullais SS, Das G, Ahmad W, Ahmad MF, et al. Glycyrrhiza glabra (licorice): a comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology. Plants (Basel). 2021;10(12):2751.

21. Nigam M, Mishra AP, Adhikari Devkota A, Dirar AI, Hassan MM, Adhikari A, et al. Fruits of Terminalia chebula Retz.: a review on traditional uses, bioactive chemical constituents and pharmacological activities. Phytother Res. 2020;34(10):2518–2533.

22. Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154–160. doi:10.1016/S2221-1691(11)60016-6

23. Researchers using high performance liquid chromatography (HPLC) and mass spectrometry have quantified catechin and epicatechin as predominant catechins in Acacia catechu extracts, demonstrating their significant presence in the plant’s phytochemical profile.

24. Preliminary phytochemical analysis of Myristica fragrans (2025). Phytochemical screening of nutmeg seed extracts showed the presence of flavonoids along with other secondary metabolites.

25. Seneme EF, dos Santos DC, Silva EMR, Moreira Franco YE, Longato GB. Pharmacological and therapeutic potential of myristicin: a literature review. Molecules. 2021;26(19):5914. doi:10.3390/molecules26195914

26. Wang L, et al. Antibacterial activity of Cinnamomum camphora essential oil against clinical strains and its biofilm inhibition effects. PMCID: PMC7693543, 2020.

27. Farhanghi A, Aliakbarlu J, Tajik H, et al. Antibacterial interactions of pulegone and 1,8 cineole with monolaurin or nisin against Staphylococcus aureus. Food Sci Nutr. 2022;10:2659–2666..

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Published

2025-04-07

How to Cite

1.
Misra S, Agrawal N, Chandravanshi L, Rathia S, Prasad K, Thakur P. “A Comparative Clinical Study To Evaluate The Efficacy Of Darvyadi Churna Lepa And Khadiradi Vati In The Management Of Mukhapaka In Children”. J Neonatal Surg [Internet]. 2025 Apr. 7 [cited 2026 May 22];14(12S):1298-304. Available from: https://jneonatalsurg.com/index.php/jns/article/view/10200

Issue

Vol. 14 No. 12S (2025): Journal of Neonatal Surgery

Section

Original Article

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