Nigella Sativa as biocoating / osteogenic agent

Authors

  • Pratik R. Pipalia
  • Ashok V
  • Subhabrata Maiti
  • Sannishth Sadrani
  • Ranjeeta Mehta

Keywords:

Nigella sativa, Thymoquinone, Hydroxyapatite, Biocoating, Osteogenesis, Osseointegration, Antimicrobial, Osteoporosis, Bone Tissue Engineering, Implantology

Abstract


Nigella sativa, a medicinal plant rich in bioactive compounds such as thymoquinone, has gained attention as a natural osteogenic and antimicrobial agent for biomedical applications, particularly in implantology. Its incorporation as a biocoating on hydroxyapatite and metallic implants has demonstrated enhanced osteoblast differentiation, improved osseointegration, and significant antimicrobial activity against oral pathogens. The plant’s anti-inflammatory and antioxidant mechanisms further support bone regeneration by reducing oxidative stress and inflammatory cytokine production. Comparative studies reveal that Nigella sativa performs on par with or superior to other natural osteogenic agents like curcumin and green tea extract. While in vitro and in vivo findings confirm its promising osteoinductive and biocompatible properties, further studies are warranted to establish standardized formulations, assess long-term toxicity, and validate clinical safety for implant-based applications..

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Published

2026-03-16

How to Cite

1.
R. Pipalia P, V A, Maiti S, Sadrani S, Mehta R. Nigella Sativa as biocoating / osteogenic agent. J Neonatal Surg [Internet]. 2026 Mar. 16 [cited 2026 Mar. 17];15(1s):58-64. Available from: https://jneonatalsurg.com/index.php/jns/article/view/10100

Issue

Vol. 15 No. 1s (2026): Journal of Neonatal Surgery

Section

Original Article

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