Formulation and Evaluation of Microsphere-Encapsulated Topical Gel.

Authors

  • Shivani Fotedar
  • Mohini Sihare

Keywords:

Itraconazole, Antifungal, Microsphere-loaded gel, Topical formulation

Abstract

A superficial fungal infection in immunocompromised persons can cause a variety of illnesses and problems. New topical therapeutic options are urgently needed to treat these fungal infections. The current study aimed to create a stable and effective topical formulation containing itraconazole. Itraconazole, abbreviated ITZ, is an antifungal drug used to treat various fungal infections. It is an FDA-approved new azole antifungal medication that combats fungal infections. Fluconazole should not be taken orally because it has various harmful effects. Fluconazole topical is commercially accessible; because there are no commercially available gel preparations, these formulations are designed to increase patient compliance, and medication dosage should be reduced to avoid undesirable effects such as renal and liver damage. It was a gel that was transformed by changing the polymer ratio. The FT-IR analysis revealed no interactions and confirmed the drug's purity. Between excipients and medication. Gel formulas were utilized to determine medication concentration, pH, antifungal activity, in vitro diffusion, and viscosity, as well as skin pain and activity levels. Some research suggested that oils from medicinal plants could be employed as anti-FLU-resistant C. albicans drugs.

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References

Thakre AR, Maske SV, Upadhye KP, Chaple DR. Optimization of clotrimazole-loaded ethyl cellulose and natural gum facilitated microsponges. Int J Drug Deliv Technol. 2024;14(4):2404–2411.

2. Gali PK, Honnesh NH, Shyamala JK, Pandhare YL, Limani GN, Chinni SV, et al. PLA and PCL microspheres for enhanced topical delivery of clotrimazole. Front Health Inform. 2024;13(3):10534–10542.

3. Sodiyal N, Yadav M, Singh R. Formulation and evaluation of clotrimazole and ketoconazole combination-loaded microsponge gel. Int J Pharm Sci. 2024;2(9):1420–1426.

4. Sureshbabu JN, Radhika GL, Ajay TR, Gowda VL. Design and evaluation of antifungal drug with corticosteroid-loaded microsponge hydrogel. J Emerg Pharm Res. 2023;10(8).

5. Shinde J, Patel R, Shriwas S. Formulation and evaluation of topical microsponge-based gel of clotrimazole. Int J Membr Sci Technol. 2023;10(2):2538–2548.

6. Gunasheela S, Chandrakala V, Srinivasan S. Development and evaluation of microsponge gel of luliconazole for topical antifungal delivery. Int J Curr Pharm Res. 2023;15(1):2069.

7. Agarwal S, Krishnamurthy K. Histology, skin. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.

8. Koh M. The skin. In: Dermatology Essentials. Springer; 2022.

9. Verma NK, Alam G, Vishwakarma DK, Mishra JN, Khan WU, Singh AP, et al. Recent advances in microspheres technology for drug delivery. Int J Pharm Sci Nanotechnol. 2022;8(2):2799–2813.

10. Waghmare R, Kale M. Design and evaluation of luliconazole-loaded microsponge gel for enhanced topical antifungal delivery. Int J Pharm Sci Res. 2022;13(11):5110–5118.

11. Singh A, Tangri SK, Chamoli M. Formulation and evaluation of microspheres-loaded topical gel for fungal infections (fluconazole). Int Res J Plant Sci. 2022;13(6):036

12. Tamboli SA, Misal RS. Design and characterization of itraconazole microsponge-based gel for improved topical antifungal therapy. Int J Pharm Sci Res. 2022;13(12):5612–5620.

13. Vyas M, Patel H, Patel V. Design and evaluation of clotrimazole-loaded microsponge gel for improved topical antifungal therapy. Int J Pharm Sci Res. 2022;13(8):3758–3766.

14. Chandrakala V, Gunasheela S, Srinivasan S. Formulation and evaluation of ketoconazole-loaded microsponge gel for topical antifungal therapy. Int J Appl Pharm. 2021;13(6):179–185.

15. Rane BR, Gujarathi NA, Patil VB. Formulation and evaluation of luliconazole microsponge gel for topical antifungal delivery. J Pharm Res Int. 2021;33(47A):109–118.

16. Dhadde G, Mali H, Raut I, Bhutkar M. A review on microspheres: types, methods of preparation, characterization, and applications. Asian J Pharm Technol. 2021;11:1–7.

17. Centers for Disease Control and Prevention. Fungal diseases homepage [Internet]. Atlanta (GA): CDC; 2021.

18. National Library of Medicine. MedlinePlus: Fungal infections [Internet]. Bethesda (MD): National Library of Medicine; 2021.

19. National Institute of Allergy and Infectious Diseases. Fungal diseases [Internet]. Bethesda (MD): NIAID; 2021.

20. Chopra H, Kumar S, Singh I. Design and evaluation of polymeric microspheres incorporated topical gel of clotrimazole for antifungal therapy. J Pharm Res Int. 2020;32(15):67–75.

21. Barlow G, Irving WL, Moss PJ. Infectious diseases. In: Feather A, Randall D, Waterhouse M, editors. Kumar and Clark’s Clinical Medicine. 10th ed. Elsevier; 2020. p. 559–563.

22. Mahajan NM, Pande VV. Design and evaluation of ketoconazole-loaded microsponge gel for enhanced topical antifungal therapy. J Drug Deliv Sci Technol. 2019;54:101315.

23. Raut SY, Bhadoria U. Microsponge-based topical delivery system for antifungal drugs: formulation and evaluation. J Pharm Res Int. 2019;29(6):1–11.

24. More SS, Nikam VK, Jagtap SR. Formulation and evaluation of clotrimazole-loaded polymeric microspheres for topical drug delivery. Int J Pharm Sci Rev Res. 2018;48(1):165–171.

25. Sharma K, Saini V, Bala S. Formulation and evaluation of antifungal microsphere-loaded topical gel of ketoconazole. Asian J Pharm Educ Res. 2018;7(2):45–53.

26. Mogal V, Derle D, Pawar A. Development and evaluation of antifungal microsphere-loaded topical gel of miconazole nitrate. Int J Pharm Sci Rev Res. 2016;40(2):144–150.

27. Katare OP, Raza K. Topical drug delivery systems: a patent review. Expert Opin Ther Pat. 2016;26(2):237–252.

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Published

2025-11-07

How to Cite

1.
Fotedar S, Sihare M. Formulation and Evaluation of Microsphere-Encapsulated Topical Gel. J Neonatal Surg [Internet]. 2025 Nov. 7 [cited 2026 May 22];14(32S):10707-15. Available from: https://jneonatalsurg.com/index.php/jns/article/view/10095

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

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