The Omega-3 Index: A Comprehensive Review of Dietary, Exercise, and Health Impacts

Authors

  • L. Sridevi
  • Chandrasekar R
  • T Susmitha
  • Kanniyakumari M
  • Renga Sundari
  • Senthamil Veni S
  • Nimeshika Devi S.V.L
  • Divya Jayachandran
  • E.Sathya Priya
  • Saravanasingh Karan Chand Mohan Singh
  • Ramamurthy Murugan

Keywords:

N/A

Abstract

The Omega-3 Index (O3I), defined as the combined percentage of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in red blood cell membranes, has emerged as a critical biomarker for assessing long-term omega-3 fatty acid status and cardiovascular health risk. This comprehensive review synthesizes current scientific understanding of the O3I, examining its modulation through dietary interventions and physical activity, and evaluating its associations with various health outcomes including cardiovascular disease, metabolic disorders, inflammation, and mortality. The evidence demonstrates that dietary intake of EPA and DHA is the primary determinant of O3I levels, while exercise plays a synergistic role in enhancing omega-3-mediated health benefits. Furthermore, the omega-6/omega-3 fatty acid ratio represents a crucial dimension of fatty acid balance with significant implications for chronic disease risk

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92. Matusheski, N. V., et al. (2017). US family physicians overestimate personal ω-3 fatty acid biomarker status: Associations with fatty fish and ω-3 supplement intake

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Published

2025-03-20

How to Cite

1.
Sridevi L, R C, Susmitha T, M K, Sundari R, Veni S S, et al. The Omega-3 Index: A Comprehensive Review of Dietary, Exercise, and Health Impacts. J Neonatal Surg [Internet]. 2025 Mar. 20 [cited 2026 May 22];14(3):395-401. Available from: https://jneonatalsurg.com/index.php/jns/article/view/10067

Issue

Vol. 14 No. 3 (2025): Journal of Neonatal Surgery

Section

Original Article

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