Case Study of Triphala Sidha Tila Taila in Acute Fissure in Ano (Parikartika): A Comprehensive Review
DOI:
https://doi.org/10.63682/jns.v14i28S.10039Keywords:
Parikartika, fissure in ano, Triphala, Tila Taila, sesame oil, matra basti, Ayurveda, wound healing, anal fissureAbstract
Parikartika, the Ayurvedic clinical correlate of acute fissure in ano, represents a significant global health concern affecting approximately 1 in 350 adults annually with a lifetime risk of 7.8%. Despite advances in conventional medical and surgical interventions, recurrence rates remain substantial, necessitating exploration of traditional Ayurvedic therapeutic modalities. Triphala Sidha Tila Taila, a classical Ayurvedic formulation combining the wound-healing properties of Triphala (Terminalia chebula, Terminalia bellerica, and Emblica officinalis) with the vata-pacifying and lubricating attributes of sesame oil (Tila Taila), presents a promising therapeutic approach for managing acute fissure in ano through topical application and matra basti (medicated oil enema) therapy.
This comprehensive review examines the therapeutic efficacy, pharmacological mechanisms, and clinical outcomes of Triphala Sidha Tila Taila in the management of acute fissure in ano (Parikartika), synthesizing evidence from classical Ayurvedic texts, contemporary clinical studies, and case reports. A systematic literature search was conducted across PubMed, Google Scholar, Scopus, and Ayurvedic databases from inception to 2025. Studies evaluating Triphala formulations, sesame oil applications, matra basti therapy, and Ayurvedic management of Parikartika were included. Data extraction focused on preparation methods, pharmacological properties, clinical outcomes, and safety profiles.
The evidence demonstrates that Triphala Sidha Tila Taila exhibits significant wound-healing, antimicrobial, anti-inflammatory, and analgesic properties. Clinical case studies report rapid symptom relief within 20 minutes to 48 hours, with complete healing observed within 7-21 days. The formulation addresses the pathophysiological triad of anal fissure: internal anal sphincter hypertonia, mucosal ischemia, and poor wound healing.
Triphala Sidha Tila Taila represents an effective, safe, and cost-effective therapeutic option for acute fissure in ano. The synergistic combination of Triphala's polyphenolic compounds and sesame oil's sesamin and sesamol content provides a multi-modal approach to pain relief, sphincter relaxation, and tissue regeneration. Further randomized controlled trials are warranted to establish standardized protocols and comparative efficacy against conventional treatments.
Downloads
References
1. Sreerag MV, Dhule M. Effect of Murivenna Ointment in the Management of Parikarthika (Acute Fissure in Ano) – A Pilot Study. Journal of Pharmaceutical Research International. 2021;33(43B):1-6. https://www.researchgate.net/publication/353638688_Effect_of_Murivenna_Ointment_in_the_Management_of_Parikarthika_Acute_Fissure_in_Ano_-_A_Pilot_Study
2. Sharma D, Gupta SK, Sarswat S. Parikartika (Fissure in Ano) A Review Study. World Journal of Pharmaceutical Research. 2024;13(5):1-8. https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/5d2db1804b29401b3695ce9f0e406643.pdf
3. Dhule M. Ayurvedic Management of Parikarthika (Acute Fissure in Ano) – A Case Study. Journal of Pharmaceutical Research International. 2021;33(43B):1-6. http://paperso.journal7publish.com/id/eprint/569/1/sciencedomain%2C%2BSreerag3343B2021JPRI73483.pdf
4. Farouk R, Duthie GS, MacGregor AB, Bartolo DC. Sustained internal sphincter hypertonia in patients with chronic anal fissure. Diseases of the Colon & Rectum. 1994;37(5):424-429. https://link.springer.com/article/10.1007/BF02076185
5. ASCRS Clinical Practice Guidelines. Management of Anal Fissures (2023). American Society of Colon and Rectal Surgeons. https://www.ascrsu.com/ascrs/view/ASCRS-Toolkit/2851088/2/Management_of_Anal_Fissures__2023_
6. Upadhyay A, John EP, Parashar I, Singh AK. A Comprehensive Review on the Management of Parikartika WSR to Fissure-in-Ano. World Journal of Pharmaceutical Research. 2025;14(1):1-12. https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/845b460652e39996f71e3038cbbfc2dc.pdf
7. Sharma N. Parikartika and Its Ayurvedic Management: A Comprehensive Review and Proposed Integrative Algorithm. International Journal on Science and Technology. 2025;2:1-10. https://www.ijsat.org/papers/2025/2/9171.pdf
8. Upadhyay SK, Asutkar S, Soni S. Comparative Analysis of Parikartika and Anal Fissure: Unraveling Diagnostic, Therapeutic, and Surgical Dimensions. Clinical Research Communications. 2023;4:1-8. https://www.tmrjournals.com/public/articlePDF/20231204/448333a0a9e9f44dcc40410ebb569302.pdf
9. Rathi P, Rathi R, Sharma N, Rathi B, Umate R. Effect of Ayurvedic Treatment on Parikartika-Fissure in Ano-A Pediatric Case Study. ResearchGate. 2020. https://www.researchgate.net/publication/351731358_EFFECT_OF_AYURVEDIC_TREATMENT_ON_PARIKARTIKA-FISSURE_IN_ANO-A_PEDIATRIC_CASE_STUDY
10. Peterson CT, Denniston K, Chopra D. Therapeutic Uses of Triphala in Ayurvedic Medicine. The Journal of Alternative and Complementary Medicine. 2017;23(8):607-614. https://pmc.ncbi.nlm.nih.gov/articles/PMC5567597/
11. Sushruta. Sushruta Samhita. Sutra Sthana, Chapter 46. Varanasi: Chaukhamba Orientalia; 2008.
12. Charaka. Charaka Samhita. Sutra Sthana, Chapter 27. Varanasi: Chaukhamba Orientalia; 2008.
13. Easy Ayurveda. Ayurvedic Herbal Oil Making: Principles, Method. https://www.easyayurveda.com/2018/01/22/ayurvedic-oil-making/
14. Mayo Clinic. Anal fissure - Diagnosis and treatment. https://www.mayoclinic.org/diseases-conditions/anal-fissure/diagnosis-treatment/drc-20351430
15. Schochet E, Khubchandani I. Pathophysiology of chronic anal fissure: current understanding and clinical applications. Società Italiana di Chirurgia Colo-Rettale. 2007. https://www.siccr.org/wp-content/uploads/2015/08/ML_Khubchandani.pdf
16. Madalinski MH. Current understanding of anal fissure pathophysiology. Advances in Biomedical Research, Proceedings. 2010;68. https://www.academia.edu/download/90989318/MABIPH-68.pdf
17. Bhardwaj R, Vaizey CJ, Boulos PB, Hoyle CH. Neuromyogenic properties of the internal anal sphincter: therapeutic rationale for anal fissures. Gut. 2000;46(6):861-868. https://pmc.ncbi.nlm.nih.gov/articles/PMC1756456/
18. Klosterhalfen B, Vogel P, Rixen D, Mittermayer C. Topography of the inferior rectal artery: a possible cause of chronic primary anal fissure. Diseases of the Colon & Rectum. 1989;32(1):43-52.
19. Gadve BN, Tantra MSS, Sase SD. Conservative Management of Parikartika WSR to Fissure in Ano A Case Study. World Journal of Pharmaceutical Research. 2021;10(5):1-8. https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/db3cdd4326a6d17682cccf25432f18c9.pdf
20. Hegde SN, K LD, Choudhary M, Menon N, Singh G. A comprehensive metabolome profiling of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica to explore the medicinal potential of Triphala. Scientific Reports. 2024;14:1-15. https://www.nature.com/articles/s41598-024-80544-6.pdf
21. Kumar NS, Nair AS, Nair AM, Murali M. Pharmacological and therapeutic effects of triphala-A literature review. Journal of Pharmacognosy and Phytochemistry. 2016;5(2):33-37. https://www.academia.edu/download/111120545/5-2-33-672.pdf
22. Singh R, Singh B, Kumar B, et al. Antioxidant activity of Triphala - a combination of Terminalia chebula, Terminalia bellerica and Emblica officinalis. Journal of Food Biochemistry. 2010;34(3):1-15. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1745-4514.2009.00326.x
23. Varma SR, Sivaprakasam TO, Mishra A, et al. Protective effects of triphala on dermal fibroblasts and human keratinocytes. PLoS One. 2016;11(10):e0145921. https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145921&type=printable
24. Kumar MS, Kirubanandan S, Sripriya R, et al. Triphala promotes healing of infected full-thickness dermal wound. Journal of Surgical Research. 2008;144(1):94-101. https://pubmed.ncbi.nlm.nih.gov/17662304/
25. Omran Z, Bader A, Porta A, et al. Evaluation of antimicrobial activity of Triphala constituents and nanoformulation. Evidence-Based Complementary and Alternative Medicine. 2020;2020:6976973. https://onlinelibrary.wiley.com/doi/pdf/10.1155/2020/6976973
26. Healthline. 10 Science-Backed Benefits of Sesame Oil. https://www.healthline.com/nutrition/sesame-oil-benefits
27. News Medical Life Sciences. Sesame Oil Health Benefits: Examining the Diverse Roles of Lignans and Lipids. https://www.news-medical.net/health/Sesame-Oil-Health-Benefits-Examining-the-Diverse-Roles-of-Lignans-and-Lipids.aspx
28. Frontiers in Chemistry. Efficacy and classification of Sesamum indicum linn seeds with emphasis on their pharmacological activities. 2024;12:1361980. https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2024.1361980/full
29. Lesielle. Sesamum indicum - Wound healing. https://www.lesielle.com/us/sesamum-indicum-seed-oilsesamum-indicum-seed-extract-in-skincare-what-is-inci-1504
30. Najafi S, Hosseini SK, Hosseini SK, et al. The Effects of Topical Sesame (Sesamum indicum) Oil on Pain Severity and Frequency of Received NSAIDs in Patients with Upper or Lower Extremities Trauma. Anesthesiology and Pain Medicine. 2015;5(3):e25341. https://pmc.ncbi.nlm.nih.gov/articles/PMC4493737/
31. Ayurveda.com. Basti Treatment in Ayurveda: Vata Balancing Panchakarma Therapy. https://ayurveda.com/blog/basti/
32. PG Scholar. Management of Parikartika (acute fissure in ano) By Tila Taila Matra basti: Case study. Yash Ayurveda. 2024. https://www.yashayurved.com/wp-content/uploads/2024/07/4.-Management-of-Parikartika-acute-fissure-in-ano-.pdf
33. Upadhyay A, John EP, Parashar I, Singh AK. A Single Case Study on the Efficacy of Apamarg Pratisarniya Kshar in the Management of Parikartika (Fissure-in-Ano). World Journal of Pharmaceutical Research. 2025;14(1):1-8. https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/c2f1514d967d702d63985ad94ee8a793.pdf
34. Sreerag MV, et al. Effective management of acute anal fissure through Sadya Vrana Chikitsā and the practice of Ashwini Mudrā. Yoga Mimamsa. 2024;56(1):1-6. https://journals.lww.com/yomi/fulltext/2024/56010/effective_management_of_acute_anal_fissure_through.9.aspx
35. Kachare K, et al. A Pilot, Prospective, Randomized-Controlled Study to Evaluate the Efficacy and Safety of Arsha Hita™ in the Treatment of Anal Fissures. PubMed Central. 2023. https://pmc.ncbi.nlm.nih.gov/articles/PMC10182782/
36. JAIMS. A randomized controlled clinical study to evaluate the efficacy of Yashtimadhu Siddha Taila Matra Basti in acute fissure-in-ano. Journal of Ayurveda and Integrated Medical Sciences. 2021. https://jaims.in/jaims/article/view/2873/4138
37. Dhule M, Sreerag MV. Effect of Murivenna Ointment in the Management of Parikarthika (Acute Fissure in Ano) – A Pilot Study. Journal of Pharmaceutical Research International. 2021;33(43B):1-6.
38. Ghodela NK, Dudhamal T. Wound healing potential of Ayurved herbal and herbo-mineral formulations: A brief review. International Journal of Herbal Medicine. 2017;5(4):1-6. https://www.researchgate.net/profile/Naresh-Ghodela/publication/313917020_Wound_healing_potential_of_Ayurved_herbal_and_herbomineral_formulations_A_brief_review/links/58afd5a6aca2725b5411308a/Wound-healing-potential-of-Ayurved-herbal-and-herbomineral-formulations-A-brief-review.pdf
39. Easy Ayurveda. Benefits, Energetics, and Healing Uses of Sesame Oil. https://ask-ayurveda.com/wiki/article/923-sesame-in-ayurveda
40. ResearchGate. An Ayurvedic Review on Tila Taila (Sesamum indicum L). 2024. https://www.researchgate.net/publication/387698475_AN_AYURVEDIC_REVIEW_ON_TILA_TAILA_SESAMUM_INDICUM_L
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.