Neonatal Perforated Appendicitis Attributed to Localized Necrotizing Enterocolitis of the Appendix: A Review

Andrew Tumen, Pranit N Chotai, John Matthew William, Adrianne Myers-Webb, Ramesh Krishnan, James W Eubanks III


Neonatal appendicitis is a rare clinical entity associated with remarkable morbidity and mortality. Appen¬dicular perforation is common and the diagnosis is usually made intra-operatively. The causative etiology of neonatal perforated appendicitis (NPA) is a subject of debate and has not been elucidated. Although many etiologic theories exist, increasing evidence suggests a subset of NPA cases may represent a form of necrotizing enterocolitis (NEC) localized to the appendix. We herein present a review of the current litera¬ture to include cases of NPA attributed to localized NEC. A high index of clinical suspicion and early laparotomy are recommended.


Neonatal perforated appendicitis; Neonatal appendicitis; Necrotizing enterocolitis; Localized NEC

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